NFL Week 16 Parlays Picks & Predictions | NFL Play of the Day

Frank AmmiranteSenior Sports Writer
Last Updated: Dec 26, 2021

It was a solid week in parlay betting. We hit one of our parlays for (+568) to win 11.36 units, which helped make it a winning week.

Let’s dive in to find my favorite parlay bets for Week 16 in the NFL pick of the day series.

Please note that all NFL gameday odds are courtesy of Caesars Sportsbook and are current as of 10:30 a.m. ET on Tuesday, December 20.

Best NFL Parlay Week 16

NFL Week 16 Top Parlay Picks

Wager: 2 Units To Win 6.82 Units (+341) at Caesars Sportsbook

  • Buffalo Bills Moneyline (+115) at New England Patriots
  • Indianapolis Colts Moneyline (+105) at Arizona Cardinals

NFL Week 16 Parlay

Buffalo Bills Moneyline (+115) at New England Patriots

The Buffalo Bills are coming off a much-needed blowout home win against the hapless Carolina Panthers. They’re still alive in the race for the AFC East and will look to avenge their home loss in that wind storm against these New England Patriots.

I believe that the Bills are the better team here. They have a significant advantage at quarterback with Josh Allen over Mac Jones. It’s going to be difficult for the Patriots to replicate their performance on the ground this time around, and you can bet that the Bills’ defense will put forth a better effort in the rematch.

The Bills came close to beating the Tampa Bay Buccaneers on the road. They also blew out the Kansas City Chiefs earlier in the year. This is a good football team that is much better than their record suggests.

Take the better team at plus money here.

Sportsbook Play Of The Day

Before making your NFL Week 16 parlay picks, you should know that Caesars Sportsbook is one of the best around. Take advantage of Caesars’ outstanding welcome bonus which matches your first bet up to $1,001 (win or lose) when you use our promo code .

Check out Chris Wassel’s Caesars Sportsbook review for more information on this betting site, or continue reading for our Week 16 parlay predictions.

Indianapolis Colts Moneyline (+105) at Arizona Cardinals

The Indianapolis Colts are absolutely rolling right now, going 8-3 in their last 11 games. Two of those losses came in overtime, with the other being a seven-point defeat at the hands of the defending Super Bowl champion Tampa Bay Buccaneers.

Running back Jonathan Taylor is an absolute monster, looking like an MVP candidate with 1,854 total yards and 19 touchdowns. He takes on a Cardinals defense that has given up big games to Craig Reynolds (112 rushing yards) and David Montgomery (90 rushing yards) in recent weeks.

The Cardinals are coming off a huge upset loss to the lowly Detroit Lions. This offense looks out of sync without DeAndre Hopkins.

Roll with the team playing better football right now.

Jonathan Taylor, RB, Indianapolis Colts

Jonathan Taylor’s stellar play has helped the Colts go 8-3 over their last 11 games and move into position to secure a playoff spot. (Image: USA TODAY Sports)

NFL Week 16 Longshot Parlay Prediction

Wager: 2 Units To Win 7.24 Units (+362) at Caesars Sportsbook

  • Jacksonville Jaguars Moneyline (+115) at New York Jets
  • Baltimore Ravens Moneyline (+115) at Cincinnati Bengals

NFL Week 16 Longshot Parlay

Jacksonville Jaguars Moneyline (+115) at New York Jets

The Jacksonville Jaguars are coming off an ugly home loss to the Houston Texans, but at least the team showed a renewed dedication to feeding their best offensive player in James Robinson. Robinson rushed for 75 yards and a touchdown against the Texans.

He’ll now get to take on the New York Jets, who have the worst defense in the NFL, especially against the run. This defense just allowed Duke Johnson to come off the street and rush for 107 yards and two touchdowns against them.

Whenever you have two terrible teams going at it, it’s usually a good bet to just ride with the underdog.

Take the Jags at plus money here.

Baltimore Ravens Moneyline (+100) at Cincinnati Bengals

The Baltimore Ravens showed a valiant effort with Tyler Huntley at quarterback, losing by only one point to the Green Bay Packers. If Lamar Jackson is forced to miss another game, the Ravens are in good hands with Huntley.

The Cincinnati Bengals are likely to be without star running back Joe Mixon for this game. They also blew out the Ravens in Baltimore earlier in the season. It’s always tough for a team to sweep their division rival, especially when both teams are so close.

The Ravens are in desperate need of a win in order to stay in playoff contention.

Give me the better-coached team at plus money. John Harbaugh is a proven winner, while Zac Taylor has made questionable decisions all year long.

Same Game Parlay Picks NFL Week 16

Wager: 2 Units to win 5.28 Units (+264) at Caesars Sportsbook

  • Tampa Bay Buccaneers -11 Point Spread & Total Points Under 44

The Tampa Bay Buccaneers are coming off a shocking 9-0 loss to the New Orleans Saints. The team is now depleted with injuries, losing stars Mike Evans, Chris Godwin, and Leonard Fournette in that game.

The good news is that Antonio Brown is ready to return from suspension.

Brown is likely to be peppered with targets in this one, along with Rob Gronkowski. The running game will be led by Ronald Jones, who has shown the ability to make big plays as the lead back. Jones rushed for 192 yards against this Carolina Panthers defense last year.

While Tampa has been weakened by injuries, they still have terrific depth on offense. The Panthers are a mess right now, and their offense looks as dysfunctional as ever.

I think that the Bucs will control this game throughout, forcing Cam Newton into mistakes. I don’t believe that Carolina will be able to score enough points to put this total Over the number.

Give me the Bucs in a low-scoring blowout.

Frank Ammirante’s 2021 NFL Parlay Betting Record: 6-42, -7.15 Units

Thanks for reading our NFL Week 16 Parlays Picks & Predictions! For more NFL Week 16 betting tips, check out our NFL bet of the day.


Frank Ammirante

Frank Ammirante is a Senior Sports Writer at The Game Day. Previously, he wrote for 4for4 Football and RotoBaller. Frank is a member of the Fantasy Sports Writer's Association while maintaining an active presence within the community. He has competed in industry contests like the Scott Fish Bowl, The Great Fantasy Baseball Invitational, and more. Frank will be making his debut in Tout Wars this year. He's got a diverse sporting background, but specializes in football and baseball.

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