Titans vs Patriots Predictions Week 12 | NFL Pick of the Day

Frank AmmiranteSenior Sports Writer
Last Updated: Nov 23, 2021

The Tennessee Titans (8-3) laid an egg last week with an unexpected loss to their lowly divisional rival, the Houston Texans (2-8). They’ll try to bounce back on the road against one of the hottest teams in the NFL, the New England Patriots (7-4).

The Patriots have won five straight games and six of their last seven, with their only loss during that span coming in overtime to the Dallas Cowboys. Their defense is playing especially well, having allowed just 13 points over their last three games combined.

These are two playoff-bound teams headed in different directions. Tennessee has struggled on offense without Derrick Henry, while New England is firing on all cylinders.

Let’s dive into our Titans vs Patriots predictions to see which team has the edge in this pivotal AFC matchup.

Please note that all NFL Week 12 odds and lines are current as of 10 a.m. ET on Tuesday, November 23.

Titans vs Patriots Prediction

The Titans are a scrappy team that has pulled off several unexpected wins against tough opponents including the Buffalo Bills, Kansas City Chiefs, and Los Angeles Rams. Before their stunning loss to the Texans, they were on a six-game winning streak.

The last time Tennessee suffered a disappointing home loss to the Arizona Cardinals in Week 1, they followed it up with an overtime road win in Seattle. Expect a much better effort from Mike Vrabel‘s team in this game, especially with their No. 1 seed on the line.

The Patriots have also found their identity as a scrappy defensive team that is strong in the trenches with a good running game and efficient quarterback. Mac Jones is completing 70.2 percent of his passes, which is the highest mark for a rookie quarterback ever.

Sportsbook Play of the Day

Before reading our Titans vs Patriots betting tips, you should know that Caesars Sportsbook is among the industry’s best, offering tons of promotions and matching your first bet up to $1,001 (win or lose) for new signups using our promo code .

Read Chris Wassel’s Caesars Sportsbook review for more insight and get your welcome bonus below, or continue reading this analysis for our Titans vs Patriots tipster picks.

Recent performance would suggest that New England is the correct side here, but I’m looking at Tennessee in this spot. I trust in Vrabel to have them ready against his former team on the road, as he did the last time they faced off during the 2019 Wild Card Game.

The Titans’ defense has also been surprisingly solid lately, allowing 22 points or less in four of their last five games. They recently gave Patrick Mahomes and Matthew Stafford fits, so don’t be surprised if they cause problems for Jones as well.

New England has a massive divisional game against Buffalo next week, so this could be a letdown spot that ends their winning streak. I think Tennessee prevails in a close game.

Prediction: Titans 23, Patriots 20

New England Patriots Defense

Can the New England Patriots’ defense come up with another big performance against the Tennessee Titans in their NFL Week 12 showdown? (Image: USA TODAY Sports)

Titans vs Patriots Best Bets

Best Bet: Titans +5.5 (-110) at Caesars

Wager: 2 Units

Given how well Tennessee has played this year, I’m surprised to see New England favored by so much on our NFL gameday odds. It seems like an overreaction to the Titans’ poor Week 11 performance, which was largely driven by Ryan Tannehill‘s four interceptions.

With both teams clicking on defense, I project this game to be a defensive struggle where neither side is able to pull away. That makes it difficult to feel comfortable siding with the Patriots on the spread, especially since Tennessee is 4-1 on the road this year.

Give me the Titans plus the points.

Best Bet: Under 44.5 Total Points (-110) at Caesars

Wager: 2 Units

The Under is 5-6 in Titans games and 6-5 in Patriots games, but both defenses are rolling right now. Tennessee’s offense is in disarray without Henry and Julio Jones and will likely struggle against a defense allowing just 16.1 points per game.

Meanwhile, New England’s run-first offense lacks explosive playmakers and has scored 25 points or less in seven of its 11 games. That trend could very well continue against an improving Titans defense that bends without breaking.

All signs point to a relatively low-scoring game on what’s expected to be a chilly day in Foxborough, making the Under our NFL bet of the day.

Frank Ammirante’s 2021 NFL Betting Record: 19-8, +19.07 Units

Thank you for reading our NFL Week 12 Titans vs Patriots Predictions! For more NFL betting tips, check out our NFL Week 12 Best Bets.


Frank Ammirante

Frank Ammirante is a Senior Sports Writer at The Game Day. Previously, he wrote for 4for4 Football and RotoBaller. Frank is a member of the Fantasy Sports Writer's Association while maintaining an active presence within the community. He has competed in industry contests like the Scott Fish Bowl, The Great Fantasy Baseball Invitational, and more. Frank will be making his debut in Tout Wars this year. He's got a diverse sporting background, but specializes in football and baseball.

Related articles


Get $1,500 in Bonus Bets

5 stars

Bet $5, Get $150 in Bonus Bets or First Bet Safety Net

5 stars

Bet $10, Get $200 in Bonus Bets

5 stars

Get A Bonus Bet Up to $1,000

5 stars

Bet $5, Get $200 in Bonus Bets

5 stars

Get A Bonus Bet Up To $250

5 stars

Bet $5, Get $200 in Bonus Bets Every Day for 5 days!

5 stars

If you or someone you know has a gambling problem and wants help, please call 1-800-GAMBLER.

21+ and present in OH. Gambling Problem? Call or text 1-800-GAMBLER (CO, DC, IL, IN, LA, MD, MS, NJ, OH, PA, TN, VA, WV, WY).

Call 877-8-HOPENY or text HOPENY (467369) (NY).

Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-270-7117 for confidential help (MI).

All betting content on TheGameDay.com is exclusively intended for audience members 21 years and older who are permitted to gamble in legal states. The Game Day may earn revenue from site visitor referrals to betting services.

Responsible Gaming: Many sportsbooks offer ways to encourage responsible gaming, including the establishment of limits to deposits, spending, and time dedicated to betting.

The Game Day is a TGD Marketing Ltd. endeavor.