49ers vs Packers Predictions | NFL Divisional Playoffs Pick of the Day

Last Updated: Jan 22, 2022

After dealing the Dallas Cowboys a devastating loss during Wild Card Weekend, the San Francisco 49ers will travel to Lambeau Field to meet the Green Bay Packers in the Divisional Round of the 2022 NFL Playoffs on Saturday night at 8:15 p.m. ET.

Similar to the Cowboys and 49ers, the Packers and 49ers also have a history in the NFL postseason. These two clubs have met in the playoffs eight times dating back to 1995 and have each won four games.

Home-field advantage has played a significant role throughout their history, as the Packers are 22-11 against the 49ers at Lambeau during the regular season and 2-1 during the postseason.

Will it matter again in this matchup? Let’s dig into our 49ers vs Packers predictions and best bets to find out.

All NFL Divisional Round odds and lines are courtesy of TwinSpires Sportsbook and current as of 2 p.m. ET on Friday, January 21.

49ers vs Packers Prediction NFC Divisional Playoffs

Entering Week 18, I said that the 49ers would be one of the most dangerous teams in the postseason if they qualified for the playoffs.

Well, as I Cowboys fan, I put my foot in my mouth. I don’t need to get into it. We all know the result that sent me into retirement from sports until I woke up the next morning. Amazing what sleep can do.

Seriously, though. From top to bottom, the 49ers are elite and hard to beat when healthy, which they proved with last week’s upset in Dallas.

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The Packers should be well-rested and healthy for this matchup after last week’s bye. They will look to remain unbeaten at home, where they are 8-0 this year.

That won’t be easy, however, as these teams match up well. We saw that during Week 3, when Green Bay narrowly edged San Francisco, 30-28.

Outside of total rushing yards per game, the Packers fielded a top-10 offense across the board while the 49ers were top-13 in all of the top categories. The 49ers were slightly better defensively, however.

Two glaring differences come in the form of yards per play and turnover differential. The 49ers were first in yards per play (6.1) while the Packers were ninth (5.8). Green Bay had the third-best turnover differential (+13), however, while San Francisco had the 10th-worst (-4).

The key to a 49ers win will come down to what they do best, which is run the football. If Elijah Mitchell and Deebo Samuel can find success on the ground, that will take some of the pressure off Jimmy Garoppolo and prevent him from making costly mistakes against Green Bay’s stingy secondary.

The Packers, on the other hand, will try to build up a lead through the air with Aaron Rodgers and then finish the game off with their rushing attack, which has had plenty of success this year between Aaron Jones and A.J. Dillon. Their defense will also try to force Garoppolo into turning the ball over under duress.

When it’s all said and done, look for this game to come down to defense. While I do think points will fly here, one of these defenses will step up and make a big play to swing the momentum and ultimately decide the game.

With home-field advantage on their side, the Packers will emerge victorious and advance to a third straight conference championship game.

Prediction: Packers 27, 49ers 24

Aaron Rodgers Green Bay Packers QB

Aaron Rodgers will look to lead the Green Bay Packers to a win over the San Francisco 49ers in the Divisional Round of the 2022 NFL Playoffs. (Image: USA TODAY Sports)

49ers vs Packers Best Bets

*Anthony Cervino is 34-32 on his NFL Best Bets for 2021 for The Game Day.

Best Bet: 49ers +5.5 (-109) at TwinSpires

Wager: 2 Units

I like the Packers to win this game. However, I believe the 49ers will cover the spread on our NFL gameday odds.

As mentioned, these teams are evenly matched and San Francisco lost by just two points the last time they met. The 49ers are also 6-4 against the Packers in their last 10 meetings, so Kyle Shanahan knows how to coach against Green Bay and has had success against them.

By taking the 49ers ATS, you get the best of both worlds. If San Francisco wins outright, you’re good. If Green Bay wins by five points or less, you’re also good.

Check out more of our 49ers vs Packers Predictions

Best Bet: Over 47 Total Points (-113) at TwinSpires

Wager: 2 Units

When these teams clash we typically see a lot of points.

The Over is 7-3 in their past 10 meetings, including four of their past five and three in a row. Their last game produced 58 total points.

Even if the weather is poor at Lambeau, I’m not worried about scoring being affected too much. The Packers are used to playing there and the 49ers love to run the ball, which helps their offense put up points in any environment.

I’d take the Over up to 49 for our NFL bet of the day.

Best Bet: Packers Moneyline (-250) at TwinSpires

Wager: 1 Unit

While I like the Packers to win here, I’m not confident enough to bet on it and recommend fading the moneylines for both teams.

But if I absolutely had to make a choice, I’d take the Green Bay moneyline. At these odds, however, I’d use it as a parlay leg rather than betting it straight up.


Anthony Cervino

Anthony Cervino is an NFL Writer and Betting Analyst for The Game Day. He is also a lifelong NFL savant and self-proclaimed league historian. In the industry, Anthony has excelled in both the fantasy football and sports betting space with fantasy his proverbial bread and butter. Anthony has made appearances on SiriusXM, amongst other publications. He is also the co-creator of the FF Faceoff (Faceoff Sports Network) and the FF Faceoff Mental Health Podathon partnered with the Hayden Hurst Foundation. Industry Clout: 15th most accurate ranker in the FantasyPros ECR for both draft and in-season accuracy (2019) | 8th most accurate ranker in the FantasyPros ECR for sleepers (2020) | 13th most accurate ranker in the FantasyPros ECR for in-season accuracy, including 2nd at quarterback and 3rd at tight end (2021).

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