Monday Night Football Prop Bets: My 3-Leg MNF Parlay For Panthers @ 49ers in Week 12

Last Updated: Nov 24, 2025

To close out Week 12 of the NFL season, we have the San Francisco 49ers hosting the Carolina Panthers.

This game will mark 49ers quarterback Brock Purdy’s second start since September, and he’s coming off a three-touchdown outing in Week 11, while Panthers quarterback Bryce Young threw for nearly 450 yards last week.

Below, you’ll find my top three Monday Night Football prop bets, culminating in a three-leg same-game parlay.

Best Monday Night Football Prop Bets for Panthers vs 49ers

All NFL odds used for these MNF player props bets are current as of Monday, Nov. 24, and courtesy of DraftKings Sportsbook.

Bryce Young: Over 0.5 Interceptions (-129)

Young has thrown seven interceptions this season, including two over his last three games. Now, he’ll take on a 49ers defense that overwhelmingly plays Cover-3.

Against this coverage, Young has thrown four interceptions and is completing less than 61% of his passes.

I think he’ll turn the ball over again on Monday, making this my NFL pick of the day.

Brock Purdy: Over 0.5 Interceptions (+106)

In addition to a Young interception, I expect Purdy to throw one too.

Like the 49ers, the Panthers also play Cover-3 far more than anything else. Opposing quarterbacks have seen it on 148 dropbacks. The next-closest coverage in terms of opposing quarterback dropbacks is Cover-6, with 63 snaps.

Against Cover-3, Purdy has thrown two of his four interceptions this season.

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Christian McCaffrey: 5+ Receptions (-187)

Heading into Week 12, McCaffrey was second in the NFL in receptions with 74. He’s caught five passes or more in all but one game this season.

Among all 49ers pass-catchers, McCaffrey leads the team in catches against Cover-3 with 20 receptions. The next closest is Kendrick Bourne and Jauan Jennings with 10.

This is easily one of the best bets for Monday Night Football.

My Three-Leg MNF Parlay for Panthers vs 49ers in Week 12 (+420)

Adding all of these best MNF prop bets into a Same Game Parlay, the odds are +420. So, if you were to wager $100 and win, you’d get $420.

Author

Richard Janvrin

Before and after graduating from the University of New Hampshire with a degree in journalism, Richard spent time writing for Bleacher Report covering the NFL, MLB, and multiple other sports. Richard has written in the online casino/sportsbook space for nearly 3 years since his time at Bleacher Report. In his free time, Richard enjoys spending time with his son, creating content on his YouTube channel, and writing music.

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