Early 2021 NFL Week 1 Odds & Lines: ATS, Moneyline & Over/Unders

Tim HeaneyDirector of Sports Content
@TeamHeaney
Last Updated: May 12, 2021

With the 2021 NFL Schedule release happening Wednesday, early leaks are revealing which games will take place in Week 1 and beyond. The betting markets are also humming. So here are our Early 2021 NFL Week 1 Odds & Lines: ATS, Moneyline & Over/Unders For Scheduled Matchups, courtesy of BetMGM. (BetMGM is offering new players a Second-Chance Bet of up to $600 where betting is legal. Sign up here to claim the welcome promotion and place your 2021 NFL bets for Week 1 games.)

Note: The Green Bay Packers at New Orleans Saints game is not listed with odds and lines yet, due to the uncertainty at quarterback for both teams, especially for the Packers and Aaron Rodgers.


Check our full thread of NFL betting picks for more 2021 NFL futures bet tips, 2021 NFL bet picks, NFL sleepers and more.


Early 2021 NFL Week 1 Odds & Lines

Thursday Night Football

Dallas Cowboys @ Tampa Bay Buccaneers Odds & Lines

  • Cowboys @ Buccaneers Moneyline: Cowboys +6.5 (-110), Buccaneers -6.5 (-110)
  • Cowboys @ Buccaneers ATS: Cowboys +6.5 (-110), Buccaneers -6.5 (-110)
  • Cowboys @ Buccaneers Over/Under: Over 52.5 (-110), Under 52.5 (-110)

Sunday Early Games For Week 1

Philadelphia Eagles @ Atlanta Falcons Week 1 Odds & Lines

  • Eagles @ Falcons Moneyline: Eagles (+165), Falcons (-200)
  • Eagles @ Falcons ATS: Eagles +3.5 (-110), Falcons -3.5 (-110)
  • Eagles @ Falcons Over/Under: Over 47 (-110), Under 47 (-110)

Pittsburgh Steelers @ Buffalo Bills Week 1 Odds & Lines

  • Steelers @ Bills Moneyline: Steelers (+225), Bills (-275)
  • Steelers @ Bills ATS: Steelers +6.5 (-110), Bills -6.5 (-110)
  • Steelers @ Bills Over/Under: Over 51 (-110), Under 51 (-110)

Minnesota Vikings @ Cincinnati Bengals Week 1 Odds & Lines

  • Vikings @ Bengals Moneyline: Vikings (-160), Bengals (+130)
  • Vikings @ Bengals ATS: Vikings -3 (-110), Bengals +3 (-110)
  • Vikings @ Bengals Over/Under: Over 47.5 (-110), Under 47.5 (-110)

San Francisco 49ers @ Detroit Lions Week 1 Odds & Lines

  • 49ers @ Lions Moneyline: 49ers (-400), Lions (+310)
  • 49ers @ Lions ATS: 49ers -7.5 (-110), Lions +7.5 (-110)
  • 49ers @ Lions Over/Under: Over 46 (-110), Under 46 (-110)

Arizona Cardinals @ Tennesee Titans Week 1 Odds & Lines

  • Cardinals @ Titans Moneyline: Cardinals (+115), Titans (-140)
  • Cardinals @ Titans ATS: Cardinals +2.5 (-110), Titans -2.5 (-110)
  • Cardinals @ Titans Over/Under: Over 51.5 (-110), Under 51.5 (-110)

Seattle Seahawks @ Indianapolis Colts Week 1 Odds & Lines

  • Seahawks @ Colts Moneyline: Seahawks (+115), Colts (-140)
  • Seahawks @ Colts ATS: Seahawks +2.5 (-110), Colts -2.5 (-110)
  • Seahawks @ Colts Over/Under: Over 52.5 (-110), Under 52.5 (-110)
Early 2021 NFL Week 1 Odds & Lines: ATS, Moneyline & Over/Unders For Each Scheduled Matchup

Russell Wilson and DK Metcalf lead the Seattle Seahawks for a road matchup with the Indianapolis Colts. Early 2021 NFL Week 1 Odds list Seattle-Indy with one of the highest point totals at 52.5. (Image: USA TODAY Sports)


Los Angeles Chargers @ Washington Football Team Week 1 Odds & Lines

  • Chargers @ WFT Moneyline: Chargers (-115), WFT (-105)
  • Chargers @ WFT ATS: Chargers -1 (-110), WFT +1 (-110)
  • Chargers @ WFT Over/Under: Over 45 (-110), Under 45 (-110)

New York Jets @ Carolina Panthers Week 1 Odds & Lines

  • Jets @ Panthers Moneyline: Jets (+175), Panthers (-225)
  • Jets @ Panthers ATS: Jets +4.5 (-110), Carolina -4.5 (-110)
  • Jets @ Panthers Over/Under: Over 43.5 (-110), Under 43.5 (-110)

Jacksonville Jaguars @ Houston Texans Week 1 Odds & Lines

  • Jaguars @ Texans Moneyline: Jaguars (-125), Texans (+105)
  • Jaguars @ Texans ATS: Jaguars -1.5 (-110), Texans +1.5 (-110)
  • Jaguars @ Texans Over/Under: Over 46 (-110), Under 46 (-110)

Sunday Late Games For Week 1

Cleveland Browns @ Kansas City Chiefs Week 1 Odds & Lines

  • Browns @ Chiefs Moneyline: Browns (+210), Chiefs (-275)
  • Browns @ Chiefs ATS: Browns +6 (-110), Chiefs -6 (-110)
  • Browns @ Chiefs Over/Under: Over 53.5 (-110), Under 53.5 (-110)

Miami Dolphins @ New England Patriots Week 1 Odds & Lines

  • Dolphins @ Patriots Moneyline: Dolphins (+110), Patriots (-130)
  • Dolphins @ Patriots ATS: Dolphins +2 (-110), Patriots -2 (-110)
  • Dolphins @ Patriots Over/Under: Over 46 (-110), Under 46 (-110)

Denver Broncos @ New York Giants Week 1 Odds & Lines

  • Broncos @ Giants Moneyline: Broncos (-115), Giants (-105)
  • Broncos @ Giants ATS: Broncos -1 (-110), Giants +1 (-110)
  • Broncos @ Giants Over/Under: Over 42.5 (-110), Under 42.5 (-110)

Sunday Night Football Week 1 Odds & Lines

Chicago Bears (+260) @ Los Angeles Rams Week 1 Odds & Lines

  • Bears @ Rams Moneyline: Bears (+260), Rams (-350)
  • Bears @ Rams ATS: Bears +7 (-110), Rams -7 (-110)
  • Bears @ Rams Over/Under: Over 45.5 (-110), Under 45.5 (-110)

Monday Night Football Week 1 Odds & Lines

Baltimore Ravens @ Las Vegas Raiders Week 1 Odds & Lines

  • Ravens @ Raiders Moneyline: Ravens (-330), Raiders (+240)
  • Bears @ Rams ATS: Bears +7 (-110), Rams -7 (-110)
  • Bears @ Rams Over/Under: Over 45.5 (-110), Under 45.5 (-110)

Author

Tim Heaney

Before joining The Game Day, Tim spent more than a decade in the fantasy sports and betting industry. Having written for ESPN, RotoWire, and USA TODAY, Tim earned an FSWA award nomination for Best MLB Print Article and multiple Top-5 finishes in fantasy baseball rankings contests. Tim has competed in Tout Wars (1 championship), LABR, Scott Fish Bowl, NFBC/NFFC, TGFBI, and RazzBowl (recent 4th-overall finish out of 200+). Drop him a line about TV, music, craft beer & pro wrestling.

Related articles

Promotions

Get Up To $1,500 in Bonus Bets

5 stars

Bet $5, Get $200 in Bonus Bets

5 stars

Bet $5, Get $200 in Bonus Bets or $1k First Bet Safety Net

5 stars

Bet $5, Get $200 in Bonus Bets

5 stars

Get A Bonus Bet Up to $1,000

5 stars

Bet $100, Get $100 in Bonus Bets Every Day for 10 days!

5 stars

Get A Bonus Bet Up To $250

5 stars

If you or someone you know has a gambling problem and wants help, please call 1-800-GAMBLER.

21+ and present in OH. Gambling Problem? Call or text 1-800-GAMBLER (CO, DC, IL, IN, LA, MD, MS, NJ, OH, PA, TN, VA, WV, WY).

Call 877-8-HOPENY or text HOPENY (467369) (NY).

Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-270-7117 for confidential help (MI).

All betting content on TheGameDay.com is exclusively intended for audience members 21 years and older who are permitted to gamble in legal states. The Game Day may earn revenue from site visitor referrals to betting services.

Responsible Gaming: Many sportsbooks offer ways to encourage responsible gaming, including the establishment of limits to deposits, spending, and time dedicated to betting.

The Game Day is a TGD Marketing Ltd. endeavor.