College Football Week 14 Upset Predictions & Picks | Biggest Upsets for Week 14

Last Updated: Dec 2, 2021

If you followed along with our upset picks last week, you did well. In fact, you did very well.

I had Minnesota (+220) over Wisconsin and LSU (+210) over Texas A&M. Both cashed, which is how you want to end college football’s final full slate of games.

This week, we’re setting our sights on conference championships and one leftover football game before we dive headfirst into bowl season.

Here are this week’s upsets, as we go hunting one last time before bowl season. And here’s to tapping into last weekend’s glorious momentum.

All NCAAF gameday odds are current as of 10:30 a.m. ET on Thursday, December 2.

CFB Week 14 Upset: No. 10 Oregon (+2.5) at No. 17 Utah

They played a few weeks ago, and it wasn’t pretty.

Utah clobbered Oregon at home, easily covering the three-point spread. While that might prompt some to overreact and jump on the Utes, the Pac-12 Championship Game might not be that simple.

Quarterback Anthony Brown is capable of guiding Oregon to a much better result. He struggled against the Utes in the previous game, although playing in lovely Las Vegas — a neutral site — should change things drastically.

On Utah’s side, Tavion Thomas is on a roll. The Utes’ star running back has become a touchdown machine. If Oregon can slow him down, Oregon can win.

That’s the blueprint.

Prediction: Oregon 34, Utah 27

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Oregon +1.5 First Half (-115) at Caesars

Wager: 1 Unit

The Ducks get off to a much better start, especially offensively, and lead Utah at halftime. Do not overreact to one game.

Sometimes, it just isn’t your day.

Oregon Moneyline (+115) at Caesars

Wager: 1 Unit

It’s not the best value, although it will do. Oregon goes wire-to-wire to win the Pac-12 Championship Game, making this our NCAAF pick of the day.

CFB Week 14 Upset: No. 16 Wake Forest (+3) at No. 15 Pittsburgh

It’s possible, perhaps even likely, that this will wind up being the best game of the weekend.

The ACC Championship Game features two teams that will not make the College Football Playoff. It also features two of the top five scoring offenses in the country.

This is a nice way of saying you should absolutely be paying attention to this matchup.

Quarterbacks Kenny Pickett and Sam Hartman are explosive, and they will both make plays in this game. Both offenses should score plenty — and I’ll get to that — although Wake Forest has been a resilient team all season.

Both teams have covered the spread in the two of the past three games, and both have done so with a healthy deluge of points. That is almost certainly to be the case once again, which is why you must watch.

Still, having just given head coach Dave Clawson a long-term extension — one that was well earned — I believe Wake Forest delivers and wins the ACC.

Prediction: Wake Forest 44, Pittsburgh 41

Over 71.5 Points (-110) at Caesars

Wager: 1 Unit

The quarterbacks are great, the offenses are fun and the defenses aren’t good enough to keep up. This is great news for everyone in need of entertainment.

Wake Forest Moneyline (+130) at Caesars

Wager: 1 Unit

It’s been a magical year for Wake Forest, and it ends in the most magical way possible. Well, minus a CFP appearance.

CFB Week 14 Upset: USC (+4) at California

This game will not decide a conference championship. Let’s be clear out of the gate.

When USC and Cal meet on Saturday, both teams will say farewell to forgettable seasons.

USC fired former head coach Clay Helton months ago. In fact, he has since been hired for another job. Cal recently scored just three points against Arizona, which doesn’t require much else in terms of description.

But the game, which was originally set to be played in November before being postponed due to COVID, will be played amid a myriad of madness. And USC, fresh off hiring head coach Lincoln Riley, will likely try to make an impression.

The Trojans battled against BYU last week, and I expect that effort to carry over. While USC lost, we saw a glimpse into the future and the potential with young QB Jaxson Dart. We will see more potential this week.

Prediction: USC 30, Cal 24

USC +3 First Half (-115) at Caesars

Wager: 1 Unit

Last week’s game against BYU showed us that the Trojans still have some firepower. They pick up where they left off.

USC Moneyline (+155) at Caesars

Wager: 1 Unit

The Trojans’ young QB gives a glimpse into the future, and USC caps off a wild week on an incredibly high note.

Thanks for reading our CFB Week 14 Upsets! For more college football betting tips, check out our CFB Week 14 Best Bets.


Adam Kramer

Adam Kramer is an NFL, college football, and gambling analyst for The Game Day. While college football has long been his calling, he’s also covered sports such as boxing, horse racing, and baseball at The Game Day and in other places. He’s also written for Bleacher Report, VSiN, and various other outlets over the past decade-plus.

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