49ers-Seahawks Betting Guide for Week 8

Last Updated: Jan 9, 2021

The San Francisco 49ers visit the Seattle Seahawks at Century Link Field on Sunday at 4:25 p.m. ET. Here’s our 49ers-Seahawks Betting Guide.

San Francisco 49ers (4-3) at Seattle Seahawks (5-1)

All odds and lines from PointsBet, current as of Wednesday at 10 a.m. ET.

49ers-Seahawks Betting Guide

49ers-Seahawks Odds and Betting Lines

  • Against The Spread: Seahawks -3 (-115)/49ers +3 (-105)
  • Moneyline: Seahawks (-180)/49ers (+150)
  • Total: 54 — Over 54 (-110)/Under 54 (-110)
  • Implied Team Totals: Seahawks 28.5, 49ers 25.5

While the Seahawks were handed their first loss of the season on Sunday night at the hands of the Cardinals, the 49ers are coming in hot, winners of two straight over the Patriots and Rams.

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49ers-Seahawks Injury Report


  • LB Kwon Alexander (ankle), Questionable
  • RB Raheem Mostert (knee), OUT (IR)
  • LT Trent Williams (ankle), Questionable
  • RB Jeff Wilson (calf), Out (IR)
  • WR Deebo Samuel (hamstring), Out


  • S Jamal Adams (groin), Questionable
  • RB Carlos Hyde (shoulder), Questionable
  • RB Chris Carson (foot), Out
  • OL Mike Iupati (back), Questionable
  • TE Will Dissly (Achilles), Questionable

49ers-Seahawks Players to Watch

Seahawks QB Russell Wilson has been on an absolute tear this season. He’s also played extremely well when facing his Sunday afternoon opponents.

Although Wilson has thrown for fewer than 237 yards in each of his past five games against the 49ers, he’s accounted for at least 2 touchdowns in four of those matchups — two of which went for at least three. Wilson has also rushed for at least 14 yards in every one of those games while only throwing two picks in that time period.

49ers-Seahawks Betting Guide: Seattle Seahawks QB Russell Wilson
Seahawks QB Russell Wilson is 13-4 lifetime vs. the 49ers. (USA TODAY Sports)

Wilson is 13-4 lifetime against the 49ers with two of those losses occurring in his past three games.

49ers TE George Kittle is one of the league’s best tight ends, but he’s never really played at an elite level, at least statistically, against the Seahawks.

In five career outings against Seattle, Kittle has accumulated fewer than 7 receptions and 86 yards in every game, finishing with fewer than three receptions and 51 yards three times. Kittle has never scored against the Seahawks.

49ers-Seahawks Weather Report

The weather at CenturyLink Field currently calls for a clear and sunny afternoon of football at kickoff with a 2% chance of precipitation.

The temperature is forecast for 55 degrees Fahrenheit with 4 mph wind gust going north.

49ers-Seahawks Betting Guide

BEST BET: Over 54 (-110)

This game features two teams that can put up points. While Seattle employs the more potent offense, the Seahawks are the NFL’s top-scoring team (33.8 PPG) and the 49ers are a middle-of-the-pack unit (16th), averaging 25.9 PPG in their own right.

The Over is 5-2 in Seattle’s last seven games overall and 4-3 in San Francisco’s seven games played this season.

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CONSIDER: 49ers (+150)

These in-division matchups are tricky. Although Seattle has the best offense in the league, its defense is horrendous. And that is being nice. Meanwhile, the 49ers have won two consecutive games over the Rams and Patriots. Neither one of those teams are easy outs.

If this game comes down to a defensive stop, my money is on the 49ers, who won their last game in Seattle last December. San Francisco is also 2-1 straight up against the Seahawks in their last three games and 2-3 in their last five.

I’d rather take the 49ers to win outright at (+150) instead of taking them getting the three points at (-105).

CONSIDER: Seahawks -3 (-115)

The Seahawks are 4-2 against the spread this season and 3-2 when giving at least three points. Meanwhile, the 49ers are 2-3 ATS this season when they are at least three-point dogs.

San Francisco is also 4-14 ATS in their last 18 games facing the Seahawks.

Seattle’s last two games have been decided by fewer than three points.

Anthony Cervino is 10-6-1 on his NFL Best Bets in 2020.

Prepare Week 8 betting tips and plan


Anthony Cervino

Anthony Cervino is an NFL Writer and Betting Analyst for The Game Day. He is also a lifelong NFL savant and self-proclaimed league historian. In the industry, Anthony has excelled in both the fantasy football and sports betting space with fantasy his proverbial bread and butter. Anthony has made appearances on SiriusXM, amongst other publications. He is also the co-creator of the FF Faceoff (Faceoff Sports Network) and the FF Faceoff Mental Health Podathon partnered with the Hayden Hurst Foundation. Industry Clout: 15th most accurate ranker in the FantasyPros ECR for both draft and in-season accuracy (2019) | 8th most accurate ranker in the FantasyPros ECR for sleepers (2020) | 13th most accurate ranker in the FantasyPros ECR for in-season accuracy, including 2nd at quarterback and 3rd at tight end (2021).

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