Monday Night Football Predictions Week 7 | MNF Picks & Saints vs Seahawks Best Bets

Last Updated: Oct 25, 2021

The New Orleans Saints will take on the Seattle Seahawks in Week 7 on Monday Night Football. In terms of personnel, this game couldn’t look more different than how these teams have stacked up over the past decade.

For the Saints, Drew Brees has retired and it’s Jameis Winston under center. For the Seahawks, it’s Geno Smith leading the offense as Russell Wilson rehabs from finger surgery. This is still an incredibly important game for both teams, but it won’t have the same level of star power that we’re used to seeing from these two NFC heavyweights.

As we look ahead to what should be a fantastic matchup between two likely playoff teams, let’s dive into our best bets for Week 7 of the MNF football predictions series.

Please note that all Saints vs Seahawks odds and lines are current as of 1 PM EST on Friday, October 22.

Sportsbook Play Of The Day

Before reading our Monday Night Football betting tips, you should know that WynnBet Sportsbook is one of the best around. Take advantage of WynnBet’s outstanding welcome bonus, which gives you a second-chance bet of up to $1,000 .

Read Juan Carlos Blanco’s WynnBet Sportsbook review for more insight and get your welcome bonus below, or continue reading this analysis for our Saints vs Seahawks tipster picks.

Monday Night Football Prediction Week 7

The Saints are coming off a much-needed Week 6 bye and should be fresh for this game. With 15 days to prepare for Smith, New Orleans’ third-ranked defense should have no problem slowing down Seattle’s limited offense.

The biggest question is if the Seahawks can limit the Saints’ 10th-ranked offense. Seattle has one of the league’s worst defenses, allowing the most yards per game in the NFL. They were slightly better against the Pittsburgh Steelers in Week 6, but that’s not saying much given Pittsburgh’s offensive woes this season.

New Orleans is inconsistent on offense, but they should be able to score 24+ points in this game with relative ease. Expect the Saints to win and hand the Seahawks their fifth loss of the year.

MNF Week 7 Pick: Saints 28, Seahawks 21

Geno Smith Seattle Seahawks QB

Can Geno Smith and the Seattle Seahawks bounce back from their Week 6 overtime loss to the Pittsburgh Steelers? (Image: USA TODAY Sports)

Monday Night Football Best Bets Week 7

MNF Best Bet: New Orleans Saints -4.5 (-110) on BetMGM

Wager: 1 Unit

With Wilson, the Seahawks are a borderline playoff team with a bad defense. Without him, however, they just aren’t a good team. Playing at home should help, but the oddsmakers are right to make the Saints a road favorite in this game, per our NFL gameday odds.

New Orleans is one of the most difficult teams in the league to figure out. They destroyed the Green Bay Packers in Week 1, but the Carolina Panthers beat them up in Week 2. Are they a playoff contender or just a middle-of-the-pack team in the NFC?

This game should tell us a lot, as the Saints need to take care of business on the road against an inferior team.

With two weeks to prepare for this game, look for Sean Payton‘s squad to come out fast and score a ton of points on the road. Pete Carroll is good at keeping games close, but New Orleans should win this game by at least a touchdown in Week 7.

MNF Best Bet: Over 42.5 Total Points (-110) on BetMGM

Wager: 1 Unit

As mentioned above, the Seahawks have arguably the worst defense in the league as they are allowing over 400 yards per game. The Saints should be able to move the ball up and down the field at will in this game, especially with a well-rested Alvin Kamara at their disposal.

The biggest question is, can Seattle keep up? Smith looked competent against the Steelers’ stout defense, and the Seahawks’ rushing attack improved as the game went on.

Seattle isn’t likely to score a ton of points in this one, but 20-24 points feels reasonable after scoring 20 against Pittsburgh in Heinz Field. If the Seahawks can accomplish that, the Over should hit with ease, making this our NFL bet of the day.

Thanks for reading our NFL Week 7 MNF Predictions & Best Bets! For more NFL betting tips, check out our NFL Week 7 Best Bets.


Marcus Mosher

Marcus Mosher is an NFL analyst at The Game Day, residing in Erie, PA. He covers the NFL from a betting and fantasy perspective, producing written and video content. Marcus currently hosts multiple football-related podcasts and is a managing editor at USA Today’s Sports Media Group covering the Las Vegas Raiders. He has previously worked at The Athletic and Bleacher Report.

Related articles


Get $1,500 in Bonus Bets

5 stars

Bet $5, Get $150 in Bonus Bets or First Bet Safety Net

5 stars

Bet $5, Get $150 in Bonus Bets

5 stars

Get A Bonus Bet Up to $1,000

5 stars

Bet $5, Get $200 in Bonus Bets

5 stars

Get A Bonus Bet Up To $250

5 stars

Bet $5, Get $200 in Bonus Bets Every Day for 5 days!

5 stars

If you or someone you know has a gambling problem and wants help, please call 1-800-GAMBLER.

21+ and present in OH. Gambling Problem? Call or text 1-800-GAMBLER (CO, DC, IL, IN, LA, MD, MS, NJ, OH, PA, TN, VA, WV, WY).

Call 877-8-HOPENY or text HOPENY (467369) (NY).

Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-270-7117 for confidential help (MI).

All betting content on is exclusively intended for audience members 21 years and older who are permitted to gamble in legal states. The Game Day may earn revenue from site visitor referrals to betting services.

Responsible Gaming: Many sportsbooks offer ways to encourage responsible gaming, including the establishment of limits to deposits, spending, and time dedicated to betting.

The Game Day is a TGD Marketing Ltd. endeavor.