Chargers vs Chiefs Predictions Week 3 – NFL Pick of the Day

Last Updated: Sep 24, 2021

Both the Kansas City Chiefs and Los Angeles Chargers enter Week 3 at 1-1 following rough Week 2 losses. While the Chargers lost a hard-fought game to the Dallas Cowboys by a field goal, the Chiefs fell short by one point in a wild Sunday Night Football shootout against the Baltimore Ravens.

Both clubs will be looking to bounce back in Week 3, with the Chiefs returning to Arrowhead Stadium to host their AFC West rivals. In what should be a close, high-scoring game between two of the NFL’s best young quarterbacks, there are plenty of bet picks to consider. Let’s dive in with our NFL Week 3 Chargers vs Chiefs predictions and betting tips.

Best Bet: Over 55 Total Points (-110) at BetMGM

For in-depth analysis of this NFL bet of the day, continue reading. Please note that all odds are current as of Friday, September 24.

Sportsbook Play of the Day

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Read Anthony Cervino’s BetMGM Sportsbook review for more insight and get your welcome bonus below, or continue reading our NFL pick of the day.

Chargers vs Chiefs Prediction

After splitting their first two games, the biggest concern for the Chargers has to be their rushing attack, which has been held below 100 yards in both contests. Meanwhile, they allowed more than 200 yards on the ground to Dallas in Week 2. Controlling the run game on both sides of the ball will be critical to defeating Kansas City, as Baltimore proved last Sunday.

The Chiefs, meanwhile, have been exposed defensively by allowing 65 points over the first two games combined. Kansas City’s defense will need to tighten up against a Los Angeles offense that could be poised to break out after scoring just 37 points during the first two weeks combined.

While neither team is firing on all cylinders yet, this should be an entertaining matchup between two of the league’s best passers. Patrick Mahomes and Justin Herbert have thrown for over 330 yards in all four of their games this year, combining for eight touchdowns through the air.

Both teams will put points on the board, but Kansas City has the edge with Mahomes at home. Look for the Chiefs to prevail in a tightly contested affair in Week 3.

Prediction: Chiefs 31, Chargers 27

Chargers vs Chiefs Best Bets

Best Bet: Over 55 (-110) at BetMGM

I really like the Over here. Kansas City is always a threat to put up a ton of points, but they can be scored on. While the Chargers’ offense has been a disappointment thus far, they have the weapons to respond to Chiefs drives and keep the game close.

With so much offensive talent on both sides, this game has the potential to be one of the highest-scoring contests of the week. Give me the Over.

Best Bet: Chargers +7 (-110) at BetMGM

As mentioned, Kansas City’s defense has been giving up points left and right this year. The Chiefs have only outscored their opponents by three total points despite ranking third in points scored.

If LA’s defense can slow Kansas City down just a little bit, Herbert and co. should be able to score enough points to keep the game close and cover the spread. While I think the Chiefs will win, I don’t expect it to be by a full touchdown.

Best Bet: Chargers Moneyline (+260) at DraftKings

The Chiefs haven’t looked like their dominant selves this year and may be vulnerable against an improving Chargers team that has played two great games thus far. With Kansas City still working out the kinks on defense, Los Angeles could take advantage and pull off the upset.

With so much randomness during the first few weeks of the NFL season, anything can happen. LA is worth taking a small-unit bet on, and DraftKings has the best Chargers moneyline odds per our NFL gameday odds.

Chargers vs Chiefs Same Game Parlay Pick

Over 54.5 Total Points & Chargers +6.5 (+290) at BetMGM

  • Over 54.5 Total Points (-115) at BetMGM
  • Chargers +6.5 (+105) at BetMGM

Here is a nice, simple parlay to use for this Sunday’s Chargers vs Chiefs game. As mentioned above, Los Angeles has enough balance to hang with Kansas City and approach 30 points, which makes combining the Over with the Chargers spread an attractive parlay.


Chris Wassel

Chris Wassel is an NHL Writer and Betting Analyst for The Game Day. He is also a frequent guest of the NHL Fantasy On Ice podcast along with hosting his own Fantasy Hockey X podcast. Chris is a jack of all trades writer who covers the NFL, NCAA Football, Auto Racing, and so much more. He is a fantasy sports veteran of nearly three decades in all.

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