NFL Week 10 Parlays Picks & Predictions | NFL Play of the Day

Frank AmmiranteSenior Sports Writer
Last Updated: Nov 14, 2021

It was a week of close calls for my parlays, as the first two missed out by one game. The Houston Texans cost us with their eight-point loss, mostly caused by Tyrod Taylor‘s careless turnovers.

My Team vs Team predictions have been more successful, as I’m currently up over 13 units for the season. Hopefully this week we can get the parlays going as well.

Let’s take a deeper dive to see what my favorite parlay bets are for Week 10 in the NFL pick of the day series!

Please note that all odds are from Caesars Sportsbook, current as of Tuesday, November 9, at 10 AM ET.

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Best NFL Parlay Week 10

NFL Week 10 Top Parlay Picks

Wager: 2 Units To Win 11.92 Units (+596) at Caesars

  • Carolina Panthers +10 (-110) @ Arizona Cardinals
  • New Orleans Saints +3 (-110) @ Tennessee Titans
  • Washington Football Team +9.5 (-110) vs Tampa Bay Buccaneers

NFL Week 10 Best Parlay Bet

Carolina Panthers +10 (-110) @ Arizona Cardinals (Caesars)

The Panthers are coming off a 24-6 home loss to the New England Patriots, but their defense played well, holding Mac Jones to a season-low 139 passing yards.

Sam Darnold continued to struggle, however, and it wouldn’t be surprising if he gets benched for this game, as he’s been arguably the worst signal-caller in the NFL over his last five games.

Carolina is now healthy with Christian McCaffrey back in the fold and we could see a motivated team if head coach Matt Rhule turns to P.J. Walker at quarterback.

Meanwhile, the Cardinals are coming off an impressive road win against the division-rival San Francisco 49ers. It was a statement win without stars Kyler Murray and DeAndre Hopkins, both of whom were unable to play due to injury and may be less than 100% if they suit up here.

This makes Arizona ripe for a letdown. The Panthers’ defense continues to be stingy against the pass, limiting opposing quarterbacks to only 6.56 yards per attempt (4th in NFL).

It’s tough to cover a 10-point spread against such a good defense, so I’ll take the Panthers and the points in this one.

New Orleans Saints +3 (-110) @ Tennessee Titans (Caesars)

The Saints saw their three-game winning streak come to an end last week with a disappointing 27-25 loss to the Atlanta Falcons at home. They just couldn’t get much going on offense with Trevor Siemian, managing just three points until the fourth quarter.

This team is better than what they showed against Atlanta, with impressive wins over Super Bowl contenders such as the Tampa Bay Buccaneers and the Green Bay Packers. They’ve also yet to lose consecutive games this season.

New Orleans will try to bounce back in Tennessee against a red-hot Titans team that’s won five in a row. In their first game without Derrick Henry last week, Tennessee crushed the Los Angeles Rams, 28-16, on Sunday Night Football.

The Titans have gotten lucky with several of their wins, however, three of which have come by a field goal. The point spread speaks volumes to me here, as oddsmakers are making Tennessee only three-point favorites after such an impressive stretch of wins.

Tennessee’s offense also struggled mightily without Henry, managing just 194 total yards against Los Angeles. Their defense won them the game, but the Titans’ defense isn’t strong enough to win games consistently.

It’s certainly possible that we see another poor outing for Ryan Tannehill and co. against a tough Saints defense. Give me New Orleans plus the points in our NFL bet of the day.

Washington Football Team +9.5 (-110) vs Tampa Bay Buccaneers (Caesars)

Washington and Tampa Bay will meet up this Sunday after being on bye last week. Both teams lost their most recent game as well, giving them polar-opposite records thus far (6-2 for Tampa, 2-6 for Washington).

It’s worth remembering how close these two teams played in last year’s NFC Wild Card Game, which Washington narrowly lost 31-23 in Taylor Heinicke‘s only start of the season. Accordingly, it wouldn’t surprise me to see a close game in this rematch as well.

It’s tough to cover a 9.5-point spread on the road, even if you’re as good as the Bucs. Both of Tampa Bay’s losses this year have come on the road, while their two road wins were by a combined eight points.

Let’s roll with Washington in this one.

Antonio Gibson Taylor Heinicke Washington Football Team

Can the Washington Football Team keep the game close against Tom Brady and the defending Super Bowl champion Tampa Bay Buccaneers in NFL Week 10? (Image: USA TODAY Sports)

NFL Week 10 Longshot Parlay Prediction

Wager: 1 Unit To Win 9.54 Units (+954) at Caesars

  • Minnesota Vikings Moneyline (+125) @ Los Angeles Chargers
  • Philadelphia Eagles Moneyline (+140) @ Denver Broncos
  • Cleveland Browns Moneyline (-105) @ New England Patriots

NFL Week 10 Longshot Parlay

Minnesota Vikings Moneyline (+125) @ Los Angeles Chargers (Caesars)

The Vikings lost yet another close game last week, falling to the Baltimore Ravens in overtime. While Minnesota is 3-5 this year, all five of their losses have been by one possession.

This team is much better than their record suggests and Dalvin Cook looks back to full health, making them a dangerous team on offense.

Meanwhile, the Chargers have been up-and-down lately, losing two of their last three and barely beating the Philadelphia Eagles. This week figures to be a close game as well.

This game is a must-win for the Vikings, making them a live dog in this spot.

Philadelphia Eagles Moneyline (+140) @ Denver Broncos (Caesars)

The Eagles have played much better football over the last two weeks, obliterating the hapless Detroit Lions and losing by three to a tough Chargers team. This is because Philly has started to emphasize the running game, adding more balance on offense and making life easier for quarterback Jalen Hurts.

Eagles running backs have combined for 258 rushing yards on 76 carries over the last two weeks. While they haven’t always been efficient, they’ve helped take some pressure off Hurts.

Philly travels to Denver to take on a Broncos team that surprisingly routed the Dallas Cowboys last week. It wouldn’t surprise me to see Denver stumble here, especially with how erratic they’ve played this year.

Cleveland Browns Moneyline (-105) @ New England Patriots (Caesars)

The Browns look like a different team with Nick Chubb back in the lineup. They’re coming off their biggest win of the season after destroying the Cincinnati Bengals by 25 points on the road.

Chubb went off for 137 yards and two touchdowns on only 14 carries. Cleveland’s running game is quite possibly the best in football, with their offensive line ranking first in Adjusted Line Yards.

We’ve seen the Patriots get gashed on the ground this year, namely by Leonard Fournette who rushed 20 times for 92 yards against them in Week 4.

New England has won three in a row, but this Browns defense has allowed 16 points or less in three straight contests and could have a similar performance against a Patriots offense that’s been hit-or-miss this year.

Same Game Parlay Picks NFL Week 10

Indianapolis Colts vs Jacksonville Jaguars

Wager: 2 Units To Win 5.28 Units (+264) at Caesars

  • Indianapolis Colts -10.5 (-110)
  • Total Points Under 47.5 (-110)

NFL Week 10 Jaguars vs Colts SGP

The Colts are playing great football right now, going 4-2 over their last six games with both of their losses coming in overtime. All of their wins during that time have come by double-digits as well, so they’re more than capable of blowing out their opponents.

Running back Jonathan Taylor looks like the best in football right now, while quarterback Carson Wentz is enjoying one of the best stretches of his career.

The Jaguars are fresh off a shocking upset of the Buffalo Bills, but that was likely an aberration. This is the same Jacksonville defense that got shredded by Geno Smith the week before, after all.

Look for Indy to win by two touchdowns at home, although I don’t think the Jaguars score enough points to hit the Over on our NFL gameday odds.

Frank Ammirante’s 2021 NFL Parlay Betting Record: 2-25, -17.87 Units

Thanks for reading our NFL Week 10 Parlays Picks & Predictions! For more NFL Week 10 betting tips, check out our NFL Week 10 Best Bets.


Frank Ammirante

Frank Ammirante is a Senior Sports Writer at The Game Day. Previously, he wrote for 4for4 Football and RotoBaller. Frank is a member of the Fantasy Sports Writer's Association while maintaining an active presence within the community. He has competed in industry contests like the Scott Fish Bowl, The Great Fantasy Baseball Invitational, and more. Frank will be making his debut in Tout Wars this year. He's got a diverse sporting background, but specializes in football and baseball.

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