2021 NFL Early Lines Week 5 – Opening Betting Odds & Implied Totals for NFL Games This Week

Last Updated: Oct 4, 2021

Checking NFL early lines each week gives prospective football bettors a solid idea of trends that the sportsbooks and the public will enact for that week’s action.

To offer our NFL readers perspective, we’ve gathered some Week 5 NFL Opening Lines and Odds, including moneyline, against the spread, Over/Under, and implied total information to start your betting off right.

2021 NFL Early Lines Week 5: Opening Odds & Betting Info for NFL Games This Week

All Week 5 NFL gameday odds and lines are current as of 8 p.m. ET on Sunday, October 3.

Los Angeles Rams at Seattle Seahawks (Thursday Night Football, 8:20 p.m. ET, Caesars)

  • Moneyline: Rams (-110), Seahawks (-110)
  • Spread: Rams PICK (-110), Seahawks PICK (-110)
  • Over/Under Points Total: Over 53.5 (-110), Under 53.5 (-110)
  • Implied Score: Rams 26.75, Seahawks 26.75

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New York Jets at Atlanta Falcons (9:30 a.m. ET, Caesars)

  • Moneyline: Jets (+155), Falcons (-180)
  • Spread: Jets +3.5 (-115), Falcons -3.5 (-105)
  • Over/Under Points Total: Over 43.5 (-110), Under 43.5 (-110)
  • Implied Score: Jets 20, Falcons 23.5

The NFL’s first London game of the season will take place in Week 5 with the New York Jets facing the Atlanta Falcons at Tottenham Hotspur Stadium in what should be a close contest.

Jets rookie quarterback Zach Wilson turned things around in Week 4, throwing two fourth-quarter touchdowns to lead New York to its first win of the season against the Tennessee Titans. Meanwhile, the Falcons gave up two touchdowns in the final four minutes to fall 34-30 to the Washington Football Team.

Neither of these teams are particularly good, so I’ll take the points with the Jets catching more than a field goal.

Denver Broncos at Pittsburgh Steelers (1 p.m. ET, Caesars)

  • Moneyline: Broncos (-110), Steelers (-110)
  • Spread: Broncos PICK (-110), Steelers PICK (-110)
  • Over/Under Points Total: Over 40.5 (-110), Under 40.5 (-110)
  • Implied Score: Broncos 20.25, Steelers 20.25

Detroit Lions at Minnesota Vikings (1 p.m. ET, Caesars)

  • Moneyline: Lions (+320), Vikings (-420)
  • Spread: Lions +8.5 (-110), Vikings -8.5 (-110)
  • Over/Under Points Total: Over 49 (-110), Under 49 (-110)
  • Implied Score: Lions 20.25, Vikings 28.75

Tennessee Titans at Jacksonville Jaguars (1 p.m. ET, Caesars)

  • Moneyline: Titans (-200), Jaguars (+170)
  • Spread: Titans -3.5 (-110), Jaguars +3.5 (-110)
  • Over/Under Points Total: Over 48.5 (-110), Under 48.5 (-110)
  • Implied Score: Titans 26, Jaguars 22.5

Green Bay Packers at Cincinnati Bengals (1 p.m. ET, Caesars)

  • Moneyline: Packers (-180), Bengals (+155)
  • Spread: Packers -3.5 (-105), Bengals +3.5 (-115)
  • Over/Under Points Total: Over 49 (-110), Under 49 (-110)
  • Implied Score: Packers 26.25, Bengals 22.75

Philadelphia Eagles at Carolina Panthers (1 p.m. ET, Caesars)

  • Moneyline: Eagles (+170), Panthers (-200)
  • Spread: Eagles +4.5 (-110), Panthers -4.5 (-110)
  • Over/Under Points Total: Over 46.5 (-110), Under 46.5 (-110)
  • Implied Score: Eagles 21, Panthers 25.5

Miami Dolphins at Tampa Bay Buccaneers (1 p.m. ET, BetMGM)

  • Moneyline: Dolphins (+450), Buccaneers (-650)
  • Spread: Dolphins +10.5 (-110), Buccaneers -10.5 (-110)
  • Over/Under Points Total: Over 49.5 (-110), Under 49.5 (-110)
  • Implied Score: Dolphins 19.5, Buccaneers 30

New England Patriots at Houston Texans (1 p.m. ET, BetMGM)

  • Moneyline: Patriots (-500), Texans (+375)
  • Spread: Patriots -9.5 (-110), Texans +9.5 (-110)
  • Over/Under Points Total: Over 39.5 (-110), Under 39.5 (-110)
  • Implied Score: Patriots 24.5, Texans 15

New Orleans Saints at Washington Football Team (1 p.m. ET, Caesars)

  • Moneyline: Saints (-110), Washington (-110)
  • Spread: Saints PICK (-110), Washington PICK (-110)
  • Over/Under Points Total: Over 44 (-110), Under 44 (-110)
  • Implied Score: Saints 22, Washington 22

Washington and New Orleans will enter their Week 5 matchup with 2-2 records after alternating wins and losses over the opening four weeks of the season.

Taylor Heinicke led an impressive fourth-quarter comeback to help Washington past the Atlanta Falcons in Week 4, while Taysom Hill’s two rushing touchdowns weren’t enough for the Saints to avoid an embarrassing overtime defeat at home to the New York Giants.

I think the Saints are the better team in this one and should come out with a road victory.

Chicago Bears at Las Vegas Raiders (4:05 p.m. ET, Caesars)

  • Moneyline: Bears (+180), Raiders (-220)
  • Spread: Bears +4.5 (-110), Raiders -4.5 (-110)
  • Over/Under Points Total: Over 45.5 (-110), Under 45.5 (-110)
  • Implied Score: Bears 20.5, Raiders 25

Cleveland Browns at Los Angeles Chargers (4:05 p.m. ET, Caesars)

  • Moneyline: Browns (-110), Chargers (-110)
  • Spread: Browns -1 (-110), Chargers +1 (-110)
  • Over/Under Points Total: Over 50 (-110), Under 50 (-110)
  • Implied Score: Browns 25.5, Chargers 24.5

San Francisco 49ers at Arizona Cardinals (4:25 p.m. ET, Caesars)

  • Moneyline: 49ers (+180), Cardinals (-220)
  • Spread: 49ers +4 (-110), Cardinals -4 (-110)
  • Over/Under Points Total: Over 53.5 (-110), Under 53.5 (-110)
  • Implied Score: 49ers 24.75, Cardinals 28.75

New York Giants at Dallas Cowboys (4:25 p.m. ET, Caesars)

  • Moneyline: Giants (+285), Cowboys (-360)
  • Spread: Giants +7.5 (-110), Cowboys -7.5 (-110)
  • Over/Under Points Total: Over 49.5 (-110), Under 49.5 (-110)
  • Implied Score: Giants 21, Cowboys 28.5

Buffalo Bills at Kansas City Chiefs (Sunday Night Football, 8:20 p.m. ET, Caesars)

  • Moneyline: Bills (+140), Chiefs (-160)
  • Spread: Bills +3 (-110), Chiefs -3 (-110)
  • Over/Under Points Total: Over 57 (-110), Under 57 (-110)
  • Implied Score: Bills 27, Chiefs 30

Both the Bills and the Chiefs are coming off of impressive wins in Week 4 and will come in confident in a rematch of the AFC Championship Game from a season ago.

Patrick Mahomes out-dueled Josh Allen in that one, but Buffalo has scored 35+ points in three straight games and Kansas City’s defense has conceded 29+ in every game. I think the Bills win here, but I love the Over even more.

Indianapolis Colts at Baltimore Ravens (Monday Night Football, 8:15 p.m. ET, Caesars)

  • Moneyline: Colts (+260), Ravens (-330)
  • Spread: Colts +7 (+100), Ravens -7 (-120)
  • Over/Under Points Total: Over 48 (-110), Under 48 (-110)
  • Implied Score: Colts 20.5, Ravens 27.5

Thanks for reading our NFL Week 5 Early Lines!

Author

John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

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