2021 NFL Early Lines Week 10 | Opening Betting Odds & Implied Totals for NFL Games This Week

Last Updated: Nov 7, 2021

Checking NFL early lines each week gives prospective football bettors a solid idea of trends that the sportsbooks and the public will enact for that week’s action.

To offer our NFL readers perspective, we’ve gathered some Week 10 NFL Opening Lines and Odds, including moneyline, against the spread, Over/Under, and implied total information to start your betting off right.

2021 NFL Early Lines Week 10

All NFL Week 10 odds and lines are current as of 8 p.m. ET on Sunday, November 7.

Baltimore Ravens at Miami Dolphins (Thursday Night Football, 8:20 p.m. ET, Caesars)

  • Moneyline: Ravens (-330), Dolphins (+260)
  • Spread: Ravens -7 (-110), Dolphins +7 (-110)
  • Over/Under Points Total: Over 47.5 (-110), Under 47.5 (-110)
  • Implied Score: Ravens 27.25, Dolphins 20.25

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Read Chris Wassel’s Caesars Sportsbook review for more insight and get your welcome bonus below, or continue reading our NFL Week 10 odds and lines.

Cleveland Browns at New England Patriots (1:00 p.m. ET, Caesars)

  • Moneyline: Browns (+115), Patriots (-135)
  • Spread: Browns +2.5 (-110), Patriots -2.5 (-110)
  • Over/Under Points Total: Over 44.5 (-110), Under 44.5 (-110)
  • Implied Score: Patriots 23.5, Browns 21

Atlanta Falcons at Dallas Cowboys (1:00 p.m. ET, Caesars)

  • Moneyline: Falcons (+350), Cowboys (-450)
  • Spread: Falcons +9 (-110), Cowboys -9 (-110)
  • Over/Under Points Total: Over 52 (-110), Under 52 (-110)
  • Implied Score: Cowboys 30.5, Falcons 21.5

New Orleans Saints at Tennessee Titans (1:00 p.m. ET, Caesars)

  • Moneyline: Saints (TBD), Titans (TBD)
  • Spread: Saints (TBD), Titans (TBD)
  • Over/Under Points Total: Over (TBD), Under (TBD)
  • Implied Score: Saints TBD, Titans TBD

Buffalo Bills at New York Jets (1:00 p.m. ET, Caesars)

  • Moneyline: Bills (-800), Jets (+550)
  • Spread: Bills -13 (-110), Jets +13 (-110)
  • Over/Under Points Total: Over 48 (-110), Under 48 (-110)
  • Implied Score: Bills 30.5, Jets 17.5

Jacksonville Jaguars at Indianapolis Colts (1:00 p.m. ET, Caesars)

  • Moneyline: Jaguars (+425), Colts (-600)
  • Spread: Jaguars +10.5 (-110), Colts -10.5 (-110)
  • Over/Under Points Total: Over 47.5 (-110), Under 47.5 (-110)
  • Implied Score: Colts 29, Jaguars 18.5

Detroit Lions at Pittsburgh Steelers (1:00 p.m. ET, Caesars)

  • Moneyline: Lions (+360), Steelers (-475)
  • Spread: Lions +9 (-110), Steelers -9 (-110)
  • Over/Under Points Total: Over 44 (-110), Under 44 (-110)
  • Implied Score: Steelers 26.5, Lions 17.5

Tampa Bay Buccaneers at Washington Football Team (1:00 p.m. ET, Caesars)

  • Moneyline: Buccaneers (-475), Washington (+360)
  • Spread: Buccaneers -9.5 (-110), Washington +9.5 (-110)
  • Over/Under Points Total: Over 51.5 (-110), Under 51.5 (-110)
  • Implied Score: Buccaneers 30.5, Washington 21

Minnesota Vikings at Los Angeles Chargers (4:05 p.m. ET, Caesars)

  • Moneyline: Vikings (+125), Chargers (-145)
  • Spread: Vikings +2.5 (-105), Chargers -2.5 (-115)
  • Over/Under Points Total: Over 52 (-110), Under 52 (-110)
  • Implied Score: Chargers 27.25, Vikings 24.75

Carolina Panthers at Arizona Cardinals (4:05 p.m. ET, Caesars)

  • Moneyline: Panthers (+360), Cardinals (-475)
  • Spread: Panthers +10 (-115), Cardinals -10 (-105)
  • Over/Under Points Total: Over 45.5 (-110), Under 45.5 (-110)
  • Implied Score: Cardinals 27.75, Panthers 17.75

The Panthers have fallen apart after their 3-0 start, losing five of their last six games. They were just blown out by the Patriots at home and have scored a grand total of 28 points over their last three games combined as Sam Darnold has struggled.

Those woes will likely persist against the 8-1 Cardinals, who are allowing the third-fewest points per game in the NFL and have already won six games by double digits.

Arizona was able to beat the 49ers handily without Kyler Murray (ankle) in Week 9. With Murray likely to return in Week 10, the Cardinals appear poised for another blowout win at home in our NFL bet of the day.

Seattle Seahawks at Green Bay Packers (4:25 p.m. ET, Caesars)

  • Moneyline: Seahawks (+205), Packers (-250)
  • Spread: Seahawks +5.5 (-110), Packers -5.5 (-110)
  • Over/Under Points Total: Over 49.5 (-110), Under 49.5 (-110)
  • Implied Score: Packers 27.5, Seahawks 22

Assuming Russell Wilson (finger) remains out and Aaron Rodgers is able to suit up after missing Week 9 with COVID, the 7-2 Packers should have no problem beating the 3-5 Seahawks at home by a comfortable margin.

While Geno Smith has been solid in Wilson’s absence, he’ll likely struggle to put points on the board against a Green Bay defense that has held opponents to fewer than 20 points in five of its last eight games. After flustering Patrick Mahomes and Kyler Murray during the past two weeks, the Packers D should feast on Smith here.

Even if Wilson does return, he’s unlikely to be 100% and could scuffle in his first game back from the IR. Keep an eye on the injury reports as the week progresses before locking in your bets here.

Philadelphia Eagles at Denver Broncos (4:25 p.m. ET, Caesars)

  • Moneyline: Eagles (+115), Broncos (-135)
  • Spread: Eagles +2.5 (-110), Broncos -2.5 (-110)
  • Over/Under Points Total: Over 44.5 (-110), Under 44.5 (-110)
  • Implied Score: Broncos 23.5, Eagles 21

Kansas City Chiefs at Las Vegas Raiders (Sunday Night Football, 8:20 p.m. ET, Caesars)

  • Moneyline: Chiefs (-140), Raiders (+120)
  • Spread: Chiefs -2.5 (-110), Raiders +2.5 (-110)
  • Over/Under Points Total: Over 51 (-110), Under 51 (-110)
  • Implied Score: Chiefs 26.75, Raiders 24.25

The Raiders suffered their first loss under interim head coach Rich Bisaccia in Week 9, falling flat against the Giants in a 23-16 road loss coming off a bye.

That doesn’t bode well for their matchup with the Chiefs, who have won consecutive games for the first time this season since bottoming out against the Titans a few weeks ago.

If a rested Raiders defense couldn’t stop Daniel Jones and the depleted Giants in Week 9, how will they fare against Mahomes and co. in Week 10? Kansas City is certainly capable of winning this game by at least a field goal, and it wouldn’t surprise me to see this spread shift to 4-5 points on our NFL gameday odds later in the week.

Back the Chiefs to continue their winning streak in primetime.

Los Angeles Rams at San Francisco 49ers (Monday Night Football, 8:15 p.m. ET, Caesars)

  • Moneyline: Rams (TBD), 49ers (TBD)
  • Spread: Rams (TBD), 49ers (TBD)
  • Over/Under Points Total: Over (TBD), Under (TBD)
  • Implied Score: Rams TBD, 49ers TBD


Tyler Maher

Tyler Maher is a Content Editor for The Game Day, where he edits and writes for the site. Prior to joining The Game Day, he was a fantasy baseball writer and social media editor for MLB.com. A graduate of Tufts University, Tyler is a die-hard Boston sports fan who can't wait for the next duck boat parade.

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