MLB Betting Pick of the Day: Best Baseball Pick Today 7/22/21

Last Updated: Jul 22, 2021

Here is our best MLB Betting Pick of the Day, including the Best Baseball Pick Today, 7/22/21. All odds for July 22 MLB bet picks were obtained from DraftKings.

It’s been another profitable week on The Game Day with MLB picks. We’ve already gone 2-0 this week, and tonight we’ll be looking to sweep with another victory.

Here are some tips for my Best Baseball Pick Today 7/22/21.

  • Overall: 24-17 (+3.86 units)
  • Team Totals: 10-7 (+0.62 units)
  • First 5 IP Bets: 10-5-3 (+4.04 units)
  • Moneylines: 3-3 (-0.5 units)
  • Totals: 1-1 (-0.3 units)

MLB Betting Pick of the Day: Best Baseball Pick Today 7/22/21

Tampa Bay Rays @ Cleveland Indians (7:10 p.m. ET)

  • Probable Pitchers: TB RHP Luis Patiño @ CLE RHP Cal Quantrill

Rays Over 2.5 Runs In First Five Innings (-105)

Wager: 1.05 units

All July 22 MLB odds, lines, and bets are courtesy of DraftKings. DraftKings offers a deposit bonus of up to $1,000 with your first deposit. Sign up to claim this welcome promotion today to place your 2021 MLB bets today.

The Rays come into Thursday’s game against the Indians with a 57-39 record. While their pitching has been stellar as usual, they’ve also fielded a potent lineup that ranks fifth in the American League in runs scored.

Since May 13, Tampa Bay has gone 38-20 while averaging 5.43 runs per game. The Rays have also been much better offensively on the road, averaging 5.29 runs per game away from Tropicana Field versus 4.48 runs per game at home.

They’ll look to continue that trend in Cleveland on Thursday against Quantrill, who’s been struggling lately. Over his last five starts, the 26-year-old righty has been knocked around to the tune of a 6.38 ERA, a 1.54 WHIP, and an .897 opponent OPS. He’s also allowed at least three runs in four of those outings.

While Quantrill’s been bad in general lately, lefties have been absolutely killing him. In their last 50 plate appearances against him, southpaws have a .447 wOBA and a .378 ISO. That doesn’t bode well for Quantrill given that Tampa Bay’s projected lineup for tonight features seven lefties, plus a pair of dangerous righties in Randy Arozarena and Mike Zunino.

Accordingly, Quantrill figures to have a tough time with the Rays tonight. They should be able to score early and often against him, cashing this bet for us in the process.

Thanks for reading our best MLB Betting Pick of the Day! For more July 22 MLB bet tips, check out our 7/22 MLB Prop Bets and 7/22 NRFI Bet as well.


Jason Radowitz

Jason Radowitz is a jack of all trades when it comes to writing sports. Jason writes and bets the MLB, NFL, NBA, NCAAF, and NCAAB when the sports are in season. Currently, he's a Writer and Betting Analyst for The Game Day providing daily content in the MLB. Earlier in his sports career, Jason was a graduate assistant for the University of Hartford Men's Basketball team using analytics and numbers to help put together the winningest season in program history. With his articles, you will be sure to get an analytical approach.

Related articles


Get $1,500 in Bonus Bets

5 stars

Bet $5, Get $150 in Bonus Bets or First Bet Safety Net

5 stars

Bet $10, Get $200 in Bonus Bets

5 stars

Get A Bonus Bet Up to $1,000

5 stars

Bet $5, Get $200 in Bonus Bets

5 stars

Get A Bonus Bet Up To $250

5 stars

Bet $5, Get $200 in Bonus Bets Every Day for 5 days!

5 stars

If you or someone you know has a gambling problem and wants help, please call 1-800-GAMBLER.

21+ and present in OH. Gambling Problem? Call or text 1-800-GAMBLER (CO, DC, IL, IN, LA, MD, MS, NJ, OH, PA, TN, VA, WV, WY).

Call 877-8-HOPENY or text HOPENY (467369) (NY).

Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-270-7117 for confidential help (MI).

All betting content on is exclusively intended for audience members 21 years and older who are permitted to gamble in legal states. The Game Day may earn revenue from site visitor referrals to betting services.

Responsible Gaming: Many sportsbooks offer ways to encourage responsible gaming, including the establishment of limits to deposits, spending, and time dedicated to betting.

The Game Day is a TGD Marketing Ltd. endeavor.