Virginia Tech vs LSU Final Four Predictions & Best Bets

Last Updated: Mar 31, 2023

In just her second season since arriving from Baylor, Hall of Fame coach Kim Mulkey has LSU back in contention for a national championship.

To finish the job, the No. 3 seed Tigers (32-2) will first need to get past Virginia Tech (31-4). Riding a 15-game winning streak, the top-seeded Hokies are the lone newcomer to this year’s NCAA Women’s Final Four.

The Tigers and Hokies will square off in the first national semifinal on Friday in Dallas.

Read on for my Virginia Tech vs. LSU prediction and best bets.

Doug Bonjour’s March Madness Betting Record: 2-2 (EV units)

Virginia Tech vs LSU Odds

  • Moneyline: LSU (-135) • Virginia Tech (+115)
  • Spread: LSU -2 (-110) • Virginia Tech +2 (-110)
  • Total: Over 133 (-110) • Under 133 (-110)

Note: CBB odds mentioned in this article for Virginia Tech vs LSU were used from DraftKings Sportsbook, unless otherwise noted, and are current as of Wednesday, March 29, at 9:12 p.m. ET.

Virginia Tech vs LSU Pick of the Day

Keep reading for more Virginia Tech vs LSU betting tips.

Virginia Tech vs LSU Prediction

Virginia Tech 66, LSU 63

Many didn’t pick Virginia Tech to make the Final Four, even as a No. 1 seed. UConn was seen as a more likely pick. Or, in some cases, even Tennessee.

Yet here the Hokies are, two wins from their first national title.

Angel Reese has been dominant for LSU, recording an SEC record 32 double-doubles. The Tigers likely wouldn’t be here without her.

The Maryland transfer has had some help of late, too. Alexis Morris is coming off a 21-point effort against Miami in the Elite 8.

That said, with Elizabeth Kitley and Georgia Amoore, the Hokies can soundly match up with LSU on both ends of the floor and pull off the minor upset.

📈 Keep track of NCAA Tournament winner odds to find our best March Madness bets:

Virginia Tech vs LSU Best Bets

Under 133 (-110) DraftKings Sportsbook

WAGER: 1 unit

LSU is one of most productive offenses in the country, averaging almost 82 points per game, yet the Tigers haven’t scored more than 70 since the first round. Meanwhile, Virginia Tech is unrelenting defensively, holding opponents to 57.1 points on average.

Look for that trend to continue and for a defensive struggle to ensue.

Angel Reese: Under 20.5 Pts (-110) DraftKings Sportsbook

WAGER: 1 unit

An AP All-American, Reese is averaging 23.2 points, but she was held to 13 on 4-for-15 shooting in the win over Miami.

As Reese helped in other ways (18 rebounds, four assists, three steals), Morris took a more aggressive approach and led LSU in both scoring and shot attempts.

With the 6-foot-6 Kitley manning the paint, the Hokies will likely try to get the ball out of Reese’s hands and force someone else to beat them.

Virginia Tech +2 (-110) DraftKings Sportsbook

WAGER: 1.5 units

Don’t trust Virginia Tech on the moneyline? This is a slightly more conservative approach. Either way, this feels like a game that’ll come down to one possession.


Doug Bonjour

Doug covered college and prep sports in Connecticut for more than a decade, including stints as the UConn women’s basketball and UConn football beat reporter for Hearst Connecticut Media. During his time reporting on the 11-time national champion Huskies, he covered three NCAA Final Fours. He also has written for the Associated Press and New York Times.

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