Tennessee vs Duke Predictions | Odds & Best Bets

Last Updated: Mar 17, 2023

A berth in the Sweet 16 is on the line when the East Region’s fifth-seed, Duke, squares off against No. 4 Tennessee in the second round in Orlando.

The Blue Devils rolled to a 74-51 win over No. 12 Oral Roberts on Thursday for their 10th straight victory. Duke has reached the Sweet 16 in its past four tournament appearances and six of its past eight.

But the Volunteers are standing in Duke’s path. Tennessee held off upstart No. 13 seed Louisiana 58-55 in the first round Thursday night.

Read on for my Tennessee vs Duke prediction and best bets.

Pat Pickens’ March Madness Betting Record: 1-5 (-5.9 units)

Tennessee vs Duke Odds

Note: CBB odds mentioned in this article for Tennessee vs Duke were used from DraftKings Sportsbook, unless otherwise noted, and are current as of March 17, at 10 a.m. ET.

  • Moneyline: Duke (-150) • Tennessee (+130)
  • Spread: Duke -3 (-110) • Tennessee +3 (-110)
  • Total: Over 129.5 (-110) • Under 129.5 (-110)

Tennessee vs Duke Pick of the Day

Keep reading for more Tennessee vs Duke betting tips.

Tennessee vs Duke Prediction

Duke 70, Tennessee 60

These are two of the best defensive teams remaining in the tournament, so the first team to 60 points will probably win. Duke can score, proven by the fact it has surpassed 60 points in 10 of its past 11 games.

Can Tennessee win a game with points? The Vols are 21-0 in games where they allow fewer than 60 points but just 3-10 when allowing 60-plus. I’m not sure they can hold Duke below 60.

📈 Keep track of NCAA Tournament winner odds to find our best March Madness bets:

Tennessee vs Duke Best Bets

Duke -3 (-110) DraftKings Sportsbook

WAGER: 1 Unit

Duke faced little resistance from Oral Roberts in the first round, and Tennessee needed to sweat out a win over the Ragin’ Cajuns to advance. That extra rest should serve the Blue Devils in a game where they’ll likely need to grind out a win.

Over 129.5 Total Points (-110) DraftKings Sportsbook

WAGER: 1 Unit

Duke has scored at least 70 points in seven of its past nine games and is averaging 78.5 points per game since the beginning of the ACC Tournament, including its NCAA tourney opener against Oral Roberts. If the Blue Devils surpass 70 again, the Over is extremely likely to hit.

Tennessee vs Duke Same Game Parlay

Tennessee vs Duke SGP FanDuel Sportsbook (+189)

WAGER: 1 Unit

  • Duke Moneyline
  • Over 127.5 Points

Tennessee vs Duke SGP

This one seems self-explanatory based on what’s stated above. But instead of betting on Duke to cover the spread, I took them simply to win.

The Blue Devils covering -2.5 raises the odds to +218, and I think that’ll hit too. But in a parlay setting, I’d rather be safe than sorry.

Tennessee vs Duke Props

Toggle with the widget below to find top Tennessee vs Duke prop bets and more March Madness prop odds.


Pat Pickens

Pat Pickens is a seasoned sportswriter who has covered pro sports since 2013 for various websites, including The New York Times,, Bleacher Report,, USA Today, the Associated Press and many others. His debut book, titled "The Whalers" about the history of the NHL's Hartford Whalers, was released in October 2021.

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