NFL Week 16 Parlays Picks & Predictions | NFL Play of the Day

It was a solid week in parlay betting. We hit one of our parlays for (+568) to win 11.36 units, which helped make it a winning week.

Let’s dive in to find my favorite parlay bets for Week 16 in the NFL pick of the day series.

Please note that all NFL gameday odds are courtesy of Caesars Sportsbook and are current as of 10:30 a.m. ET on Tuesday, December 20. 

Best NFL Parlay Week 16

NFL Week 16 Top Parlay Picks

Wager: 2 Units To Win 6.82 Units (+341) at Caesars Sportsbook

  • Buffalo Bills Moneyline (+115) at New England Patriots
  • Indianapolis Colts Moneyline (+105) at Arizona Cardinals

NFL Week 16 Parlay

Buffalo Bills Moneyline (+115) at New England Patriots

The Buffalo Bills are coming off a much-needed blowout home win against the hapless Carolina Panthers. They’re still alive in the race for the AFC East and will look to avenge their home loss in that wind storm against these New England Patriots.

I believe that the Bills are the better team here. They have a significant advantage at quarterback with Josh Allen over Mac Jones. It’s going to be difficult for the Patriots to replicate their performance on the ground this time around, and you can bet that the Bills’ defense will put forth a better effort in the rematch.

The Bills came close to beating the Tampa Bay Buccaneers on the road. They also blew out the Kansas City Chiefs earlier in the year. This is a good football team that is much better than their record suggests.

Take the better team at plus money here.


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Indianapolis Colts Moneyline (+105) at Arizona Cardinals

The Indianapolis Colts are absolutely rolling right now, going 8-3 in their last 11 games. Two of those losses came in overtime, with the other being a seven-point defeat at the hands of the defending Super Bowl champion Tampa Bay Buccaneers.

Running back Jonathan Taylor is an absolute monster, looking like an MVP candidate with 1,854 total yards and 19 touchdowns. He takes on a Cardinals defense that has given up big games to Craig Reynolds (112 rushing yards) and David Montgomery (90 rushing yards) in recent weeks.

The Cardinals are coming off a huge upset loss to the lowly Detroit Lions. This offense looks out of sync without DeAndre Hopkins.

Roll with the team playing better football right now.

prop bet

+341

Bills To Defeat Patriots & Colts To Defeat Cardinals

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Jonathan Taylor, RB, Indianapolis Colts

Jonathan Taylor’s stellar play has helped the Colts go 8-3 over their last 11 games and move into position to secure a playoff spot. (Image: USA TODAY Sports)


NFL Week 16 Longshot Parlay Prediction

Wager: 2 Units To Win 7.24 Units (+362) at Caesars Sportsbook

  • Jacksonville Jaguars Moneyline (+115) at New York Jets
  • Baltimore Ravens Moneyline (+115) at Cincinnati Bengals

NFL Week 16 Longshot Parlay

Jacksonville Jaguars Moneyline (+115) at New York Jets

The Jacksonville Jaguars are coming off an ugly home loss to the Houston Texans, but at least the team showed a renewed dedication to feeding their best offensive player in James Robinson. Robinson rushed for 75 yards and a touchdown against the Texans.

He’ll now get to take on the New York Jets, who have the worst defense in the NFL, especially against the run. This defense just allowed Duke Johnson to come off the street and rush for 107 yards and two touchdowns against them.

Whenever you have two terrible teams going at it, it’s usually a good bet to just ride with the underdog.

Take the Jags at plus money here.

Baltimore Ravens Moneyline (+100) at Cincinnati Bengals

The Baltimore Ravens showed a valiant effort with Tyler Huntley at quarterback, losing by only one point to the Green Bay Packers. If Lamar Jackson is forced to miss another game, the Ravens are in good hands with Huntley.

The Cincinnati Bengals are likely to be without star running back Joe Mixon for this game. They also blew out the Ravens in Baltimore earlier in the season. It’s always tough for a team to sweep their division rival, especially when both teams are so close.

The Ravens are in desperate need of a win in order to stay in playoff contention.

Give me the better-coached team at plus money. John Harbaugh is a proven winner, while Zac Taylor has made questionable decisions all year long.

prop bet

+362

Jaguars To Defeat Jets & Ravens To Defeat Bengals

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Bet $20, Payout $92


Same Game Parlay Picks NFL Week 16

Wager: 2 Units to win 5.28 Units (+264) at Caesars Sportsbook

  • Tampa Bay Buccaneers -11 Point Spread & Total Points Under 44 

The Tampa Bay Buccaneers are coming off a shocking 9-0 loss to the New Orleans Saints. The team is now depleted with injuries, losing stars Mike EvansChris Godwin, and Leonard Fournette in that game.

The good news is that Antonio Brown is ready to return from suspension.

Brown is likely to be peppered with targets in this one, along with Rob Gronkowski. The running game will be led by Ronald Jones, who has shown the ability to make big plays as the lead back. Jones rushed for 192 yards against this Carolina Panthers defense last year.

While Tampa has been weakened by injuries, they still have terrific depth on offense. The Panthers are a mess right now, and their offense looks as dysfunctional as ever.

I think that the Bucs will control this game throughout, forcing Cam Newton into mistakes. I don’t believe that Carolina will be able to score enough points to put this total Over the number.

Give me the Bucs in a low-scoring blowout.

prop bet

+264

Buccaneers @ Panthers: TB -11 & UNDER 44 Pts

TB @ CAR | 12/26, 1:00 PM ET

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Frank Ammirante’s 2021 NFL Parlay Betting Record: 6-42, -7.15 Units

Thanks for reading our NFL Week 16 Parlays Picks & Predictions! For more NFL Week 16 betting tips, check out our NFL bet of the day.

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NFL Betting News

  • Early money slightly leaning towards the over in the 49ers-Rams matchup

    DraftKings Sportsbook is reporting good two-way action on the over/under for the NFC Championship Game matchup between the San Francisco 49ers and Los Angeles Rams.

    Betting Impact:
    Per DraftKings, the over of 46 points has attracted 55% of the bets and 60% of the money thus far. Much moreso than the AFC Championship Game, the betting splits on the point spread and total in this game are much more evenly split, so the sportsbook does not have too much liability on either at the moment. From a moneyline perspective, Los Angeles's -170 moneyline odds have attracted 60% of the bets and 70% of the money.

    SF vs. LAR Game Page

  • Early bettors give slight lean to the Rams over the 49ers

    Based on the betting splits at DraftKings Sportsbook, the favored Los Angeles Rams are getting slightly more betting attention in their matchup with the San Francisco 49ers.

    Betting Impact:
    Per DraftKings, Los Angeles's -3.5 point spread has received 65% of the bets and 61% of the handle thus far. Bettors are clearly torn in this matchup considering the Rams have arguably been playing better football through the first two playoff games, while the 49ers have won six consecutive games against the Rams, including a thrilling Week 18 overtime victory in Los Angeles.

    SF vs. LAR Game Page

  • Early money more than 4/1 on the over in the Bengals-Chiefs matchup

    DraftKings Sportsbook is reporting one-sided betting action for Sunday's over/under in the matchup between the Cincinnati Bengals and Kansas City Chiefs.

    Betting Impact:
    Per DraftKings, the over of 54.5 points has attracted 75% of the bets and 85% of the money thus far. At this point, the sportsbook has big liability to the Chiefs point spread and the over in this matchup, as their most ideal scenario would be a Bengals cover in a low-scoring game at the moment. From a moneyline perspective, Kansas City's -335 moneyline odds have attracted 58% of the bets and 61% of the money.

    CIN vs. KC Game Page

  • Early money 3/1 on the Chiefs over the Bengals

    DraftKings Sportsbook is reporting one-sided betting action for Sunday's matchup between the Cincinnati Bengals and Kansas City Chiefs, as the majority of the action is backing the favored Chiefs.

    Betting Impact:
    Per DraftKings, Kansas City's -7 point spread has received 61% of the bets and 76% of the handle thus far. Cincinnati is shaping up to be the biggest need of any side or any total this weekend, as the public seems to be enamored with the Chiefs after their thrilling Divisional Round win over Buffalo.

    CIN vs. KC Game Page

  • 49ers-Rams over/under reaches lowest number of the week

    After another line movement, the over/under for the NFC Championship matchup between the San Francisco 49ers and Los Angeles Rams has reached its lowest total of the week.

    Betting Impact:
    Per DraftKings, the 49ers-Rams over/under on Sunday night was posted at 47.5 points. It was quickly bet down to 46.5 in less than 24 hours. However, it has once again moved toward the under, and now currently sits at 46 points. Given that there has not yet been buyback on the over, it is extremely unlikely we see the total get back to anywhere close to the 47.5 points it opened at.

    SF vs. LAR Game Page