2021 NFL Early Lines Week 16 | NFL Opening Betting Odds & Implied Totals This Week

Gio AnnatelliDigital Content Coordinator
Posted: Dec 21, 2021Last updated: Dec 21, 2021

Checking NFL early lines each week gives prospective football bettors a solid idea of trends that the sportsbooks and the public will enact for that week’s action.

To offer our NFL readers perspective, we’ve gathered some Week 16 NFL Opening Lines and Odds, including moneyline, against the spread, Over/Under, and implied total points score information to start your betting off right.

2021 NFL Early Lines Week 16

All NFL Week 16 odds and lines are current as of 9:00 p.m. ET on Sunday, December 19, and provided by Caesars Sportsbook.

San Francisco 49ers @ Tennessee Titans (Thursday Night Football, 8:20 p.m. ET)

  • Moneyline: 49ers (-190) @ Titans (+160)
  • Spread: 49ers -3.5 (-110) @ Titans +3.5 (-110)
  • Over/Under Points Total: Over 44.5 (-110), Under 44.5 (-110)
  • Implied Score: 49ers 24, Titans 20.5

Read our full 49ers vs. Titans Predictions for NFL Week 16 TNF.


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Read Chris Wassel’s Caesars Sportsbook review for more insight and get your welcome bonus below, or continue reading our NFL Week 16 odds and lines.


Cleveland Browns @ Green Bay Packers (Saturday, 4:30 p.m. ET)

  • Moneyline: Browns (+285) @ Packers (-360)
  • Spread: Browns +8 (-110) @ Packers -8 (-110)
  • Over/Under Points Total: Over 45 (-110), Under 45 (-110)
  • Implied Score: Packers 26.5, Browns 18.5

Indianapolis Colts @ Arizona Cardinals (Saturday, 8:15 p.m. ET)

  • Moneyline: Colts (+100) @ Cardinals (-120)
  • Spread: Colts +1 (-110) @ Cardinals -1 (-110)
  • Over/Under Points Total: Over 49.5 (-110), Under 49.5 (-110)
  • Implied Score: Cardinals 25.25, Colts 24.25

Colts @ Cardinals BEST BET: Colts Moneyline (+100)

Wager: 1 Unit

The Colts are riding the momentum, having won two in a row and five of their last six. The Cardinals are also riding some momentum, but in the wrong direction, losers of two straight.

Indianapolis is not just fighting for a Wild Card spot, but Sunday’s win moves them one game back of the Titans in the AFC South. After struggling to start the season, the team has turned things around behind the great running of Jonathan Taylor.

Arizona is coming off a tough, tough loss to the (now) two-win Detroit Lions. While the Cardinals are a talented team, they are losing their hold on the NFC West, with both the Rams and 49ers on their tail.

According to our NFL gameday odds, the Cardinals are only favored by 1.5 points. Go with the Colts here for the upset.

New York Giants @ Philadelphia Eagles (1:00 p.m. ET)

  • Moneyline: Giants (+360) @ Eagles (-475)
  • Spread: Giants +10 (-110) @ Eagles -10 (-110)
  • Over/Under Points Total: Over 42 (-110), Under 42 (-110)
  • Implied Score: Eagles 26, Giants 16

Los Angeles Rams @ Minnesota Vikings (1:00 p.m. ET)

  • Moneyline: Rams (-150) @ Vikings (+130)
  • Spread: Rams -3 (-105) @ Vikings +3 (-115)
  • Over/Under Points Total: Over 49 (-110), Under 49 (-110)
  • Implied Score: Rams 26, Vikings 23

Buffalo Bills @ New England Patriots (1:00 p.m. ET)

  • Moneyline: Bills (+115) @ Patriots (-135)
  • Spread: Bills +2.5 (-110) @ Patriots -2.5 (-110)
  • Over/Under Points Total: Over 43.5 (-110), Under 43.5 (-110)
  • Implied Score: Patriots 23, Bills 20.5

Bills @ Patriots BEST BET: Over 43.5 (-110)

Wager: 1 Units

While their Week 13 matchup ended 14-10 and Mac Jones threw for only 19 yards, don’t expect that to be the same this time around. I don’t want to be dramatic or anything, but whoever wins this game will most likely win the AFC East.

With major playoff implications on the line, both teams will put their best foot forward. That means both sides will be trying to put as many points as possible on the board.

The Bills keep going back and forth as not only the favorite in the AFC, but they go back and forth in having the best offense in the conference. With Josh Allen under center and all the weapons they have, this offense should be putting up 30 points every week.

Expect this game to be a shootout between Allen and Jones, with both coaches pulling out every trick in the book to outscore the other in our NFL bet of the day.

Tampa Bay Buccaneers @ Carolina Panthers (1:00 p.m. ET)

  • Moneyline: Buccaneers (-600) @ Panthers (+425)
  • Spread: Buccaneers -11.5 (-110) @ Panthers +11.5 (-110)
  • Over/Under Points Total: Over 45 (-110), Under 45 (-110)
  • Implied Score: Buccaneers 28.25, Panthers 16.75

Jacksonville Jaguars @ New York Jets (1:00 p.m. ET)

  • Moneyline: Jaguars (+120) @ Jets (-140)
  • Spread: Jaguars +2.5 (-110) @ Jets -2.5 (-110)
  • Over/Under Points Total: Over 41.5 (-110), Under 41.5 (-110)
  • Implied Score: Jets 22, Jaguars 19.5

Detroit Lions @ Atlanta Falcons (1:00 p.m. ET)

  • Moneyline: Lions (+170) @ Falcons (-200)
  • Spread: Lions +4 (-110) @ Falcons -4 (-110)
  • Over/Under Points Total: Over 44 (-110), Under 44 (-110)
  • Implied Score: Falcons 24, Lions 20

Los Angeles Chargers @ Houston Texans (1:00 p.m. ET)

  • Moneyline: Chargers (-550) @ Texans (+400)
  • Spread: Chargers -10.5 (-110) @ Texans +10.5 (-110)
  • Over/Under Points Total: Over 47.5 (-110), Under 47.5 (-110)
  • Implied Score: Chargers 29, Texans 18.5

Baltimore Ravens @ Cincinnati Bengals (1:00 p.m. ET)

  • Moneyline: Ravens (+115) @ Bengals (-135)
  • Spread: Ravens +2.5 (-110) @ Bengals -2.5 (-110)
  • Over/Under Points Total: Over 44.5 (-110), Under 44.5 (-110)
  • Implied Score: Bengals 23.5, Ravens 21

Ravens @ Bengals BEST BET: Bengals -2.5 (-110)

Wager: 1 Unit

The AFC North is the tightest division in the NFL, with both the Ravens and Bengals tied for the lead at 8-6 and the Browns and Steelers right behind them at 7-6 and 7-6-1, respectively.

After being the No. 1 team in the conference at one point, the Bengals fell off and have crawled their way back to the top of the division. The offense is clicking behind Joe Burrow while the defense is holding their own against opponents.

Baltimore has lost three games in a row by a combined 4 points. Absolutely brutal. Even without Lamar Jackson, the Ravens have been competitive, with Tyler Huntley playing well in his place.

The Ravens will make this a competitive game, whether it’s Jackson or Huntley is under center. However, look for the Bengals to win this game by at least a touchdown.

Chicago Bears @ Seattle Seahawks (4:05 p.m. ET)

  • Moneyline: Bears (+250) @ Seahawks (-320)
  • Spread: Bears +7 (-110) @ Seahawks -7 (-110)
  • Over/Under Points Total: Over 43.5 (-110), Under 43.5 (-110)
  • Implied Score: Seahawks 25.25, Bears 18.25

Pittsburgh Steelers @ Kansas City Chiefs (4:25 p.m. ET)

  • Moneyline: Steelers (+350) @ Chiefs (-450)
  • Spread: Steelers +10 (-110) @ Chiefs -10 (-110)
  • Over/Under Points Total: Over 46.5 (-110), Under 46.5 (-110)
  • Implied Score: Chiefs 28.25, Steelers 18.25

Denver Broncos @ Las Vegas Raiders (4:25 p.m. ET)

  • Moneyline: Broncos (-105) @ Raiders (-115)
  • Spread: Broncos +1 (-110) @ Raiders -1 (-110)
  • Over/Under Points Total: Over 42 (-110), Under 42 (-110)
  • Implied Score: Raiders 21.5, Broncos 20.5

Washington Football Team @ Dallas Cowboys (Sunday Night Football, 8:20 p.m. ET)

  • Moneyline: Washington (+360) @ Cowboys (-475)
  • Spread: Washington +10.5 (-110) @ Cowboys -10.5 (-110)
  • Over/Under Points Total: Over 47 (-110), Under 47 (-110)
  • Implied Score: Cowboys 28.75, Washington 18.25

Miami Dolphins @ New Orleans Saints (Monday Night Football, 8:15 p.m. ET)

  • Moneyline: Dolphins (+145) @ Saints (-170)
  • Spread: Dolphins +3 (+100) @ Saints -3 (-120)
  • Over/Under Points Total: Over 39 (-110), Under 39 (-110)
  • Implied Score: Saints 21, Dolphins 18

Author

Gio Annatelli

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