Cardinals vs Lions Predictions Week 15 | NFL Pick of the Day

We have a battle of two teams that are on opposite sides of the spectrum in Week 15 as the Arizona Cardinals will travel to take on the Detroit Lions. Arizona comes into this game having lost to the Los Angeles Rams on Monday Night Football, giving them a 10-3 record entering this week.

Following a double-digit loss to the Denver Broncos in Week 13, Detroit now owns a dismal 1-11-1 record, putting them in a prime position to secure the No. 1 overall pick in the 2022 NFL Draft. While the Lions aren’t oozing with talent, they are even more shorthanded due to injuries on both sides of the ball and a COVID-19 outbreak amongst the secondary.

This is a perfect spot for the Cardinals to bounce back after a disappointing loss to the Rams in Week 14. As for the Lions, they could try to spoiler against the teams they face, while trying to put together a foundation for next season as they have already been eliminated from playoff contention this year.

Continue reading below to see my Cardinals vs. Lions predictions, along with my favorite bets.

Please note that all odds are current as of 1 p.m. EST on Friday, December 17.

Cardinals vs Lions Prediction

Despite Arizona’s recent defeat to Los Angeles, make no mistake about it, they are still one of the best teams in the NFL. Kyler Murray may have fallen back in the MVP race, but he’s still playing at an All-Pro level for the Cardinals thus far.

James Conner has been a massive free-agent signing for Arizona, as he’s second in the league in rushing touchdowns, behind Jonathan Taylor. DeAndre Hopkins (knee) has unfortunately been ruled out for a few more weeks, leaving the Cardinals with Christian Kirk, A.J. Green, and Rondale Moore at wide receiver.


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On the defensive side of the ball, Arizona has an edge-rushing duo in Chandler Jones and Markus Golden that has caused issues for offenses. The Cardinals are facing a familiar face in Jared Goff, who they squared off with twice a year when he was on the Rams.

There are bound to be multiple turnovers forced by Arizona’s defense on Goff and Detroit’s lackadaisical offensive unit. We could see plenty of easy points scored by the Cardinals while the Lions struggled to muster up many points, which isn’t a new development.

It remains to be seen if D’Andre Swift or Jamaal Williams is able to return for the Lions this week. With the Cardinals motivated to get back into the win column and compete for the No. 1 seed in the NFC, it’s tough to envision the Lions putting up much of a fight in Week 15.

Prediction: Cardinals 38, Lions 13


Cardinals vs Lions Best Bets

Skyler Carlin 2021 NFL Betting Record: 4-12-0

Best Bet: Cardinals -12.5 (-110) at TwinSpires

Wager: 1 Unit

You would think by looking at Arizona’s 10-3 record that they are strong on the road and at home. But surprisingly, the Cardinals have performed much better as the visiting team, making home-field advantage a non-priority for Arizona in the playoff race.

Despite the Lions being 1-11-1 on the season, they are a solid 8-5 against the spread through their first 13 games. However, the Cardinals have covered the spread in all seven of their road contests up to this point.

Of Detroit’s 11 losses on the season, four of them have come by 18-plus points. The Lions are coming off of a 28-point defeat against the Broncos, who aren’t nearly as lethal on offense as the Cardinals.

For Arizona, in their 10 wins, seven of them have come by double-digits. Given the circumstances of both of these teams, it feels somewhat easy to predict a win for the Cardinals that is by at least two touchdowns – especially coming off of a loss.

spread

-110

Cardinals To Cover -12.5 Spread vs Lions

ARI @ DET | 12/19, 1:00 PM ET

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Bet $20, Payout $38

Best Bet: Over 47.5 Total Points (-107) at TwinSpires

Wager: 1 Unit

When looking at the projected total of 47.5 points, it may seem like a lot between two teams that are on completely different talent levels. That being said, the Cardinals are capable of scoring all of the points themselves if they can create some opportunities on defense.

Entering this week, the Lions give up the fourth-most points per game at 27.2, while the Cardinals average the fifth-most points per game as an offense at 28.2. There aren’t many outcomes I see happening in this game that result in Arizona scoring fewer than 30 points.

We also have the odds on our side as the Cardinals have hit the over in four out of their last five games and in all six of their last six meetings with the Lions. Over their first 13 games, Detroit has surrendered 34-plus points to their opponents five times, and with Arizona likely forcing Goff into making mistakes, we could see 40-plus points from the Cardinals.

With the Lions likely playing from behind, we could get some garbage time points from Detroit, helping us hit the over.

over-under

-110

Cardinals @ Lions: Over 47.5 Total Points

ARI @ DET | 12/19, 1:00 PM ET

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Bet $20, Payout $38

Thank you for reading our Cardinals vs. Lions Predictions! For more NFL betting tips, check out our NFL Week 15 Best Bets.

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NFL Betting News

  • Early money slightly leaning towards the over in the 49ers-Rams matchup

    DraftKings Sportsbook is reporting good two-way action on the over/under for the NFC Championship Game matchup between the San Francisco 49ers and Los Angeles Rams.

    Betting Impact:
    Per DraftKings, the over of 46 points has attracted 55% of the bets and 60% of the money thus far. Much moreso than the AFC Championship Game, the betting splits on the point spread and total in this game are much more evenly split, so the sportsbook does not have too much liability on either at the moment. From a moneyline perspective, Los Angeles's -170 moneyline odds have attracted 60% of the bets and 70% of the money.

    SF vs. LAR Game Page

  • Early bettors give slight lean to the Rams over the 49ers

    Based on the betting splits at DraftKings Sportsbook, the favored Los Angeles Rams are getting slightly more betting attention in their matchup with the San Francisco 49ers.

    Betting Impact:
    Per DraftKings, Los Angeles's -3.5 point spread has received 65% of the bets and 61% of the handle thus far. Bettors are clearly torn in this matchup considering the Rams have arguably been playing better football through the first two playoff games, while the 49ers have won six consecutive games against the Rams, including a thrilling Week 18 overtime victory in Los Angeles.

    SF vs. LAR Game Page

  • Early money more than 4/1 on the over in the Bengals-Chiefs matchup

    DraftKings Sportsbook is reporting one-sided betting action for Sunday's over/under in the matchup between the Cincinnati Bengals and Kansas City Chiefs.

    Betting Impact:
    Per DraftKings, the over of 54.5 points has attracted 75% of the bets and 85% of the money thus far. At this point, the sportsbook has big liability to the Chiefs point spread and the over in this matchup, as their most ideal scenario would be a Bengals cover in a low-scoring game at the moment. From a moneyline perspective, Kansas City's -335 moneyline odds have attracted 58% of the bets and 61% of the money.

    CIN vs. KC Game Page

  • Early money 3/1 on the Chiefs over the Bengals

    DraftKings Sportsbook is reporting one-sided betting action for Sunday's matchup between the Cincinnati Bengals and Kansas City Chiefs, as the majority of the action is backing the favored Chiefs.

    Betting Impact:
    Per DraftKings, Kansas City's -7 point spread has received 61% of the bets and 76% of the handle thus far. Cincinnati is shaping up to be the biggest need of any side or any total this weekend, as the public seems to be enamored with the Chiefs after their thrilling Divisional Round win over Buffalo.

    CIN vs. KC Game Page

  • 49ers-Rams over/under reaches lowest number of the week

    After another line movement, the over/under for the NFC Championship matchup between the San Francisco 49ers and Los Angeles Rams has reached its lowest total of the week.

    Betting Impact:
    Per DraftKings, the 49ers-Rams over/under on Sunday night was posted at 47.5 points. It was quickly bet down to 46.5 in less than 24 hours. However, it has once again moved toward the under, and now currently sits at 46 points. Given that there has not yet been buyback on the over, it is extremely unlikely we see the total get back to anywhere close to the 47.5 points it opened at.

    SF vs. LAR Game Page