Early 2021 NFL Week 1 Odds & Lines: ATS, Moneyline & Over/Unders

With the 2021 NFL Schedule release happening Wednesday, early leaks are revealing which games will take place in Week 1 and beyond. The betting markets are also humming. So here are our Early 2021 NFL Week 1 Odds & Lines: ATS, Moneyline & Over/Unders For Scheduled Matchups, courtesy of BetMGM. (BetMGM is offering new players a Risk-Free Bet of up to $600 where betting is legal. Sign up here to claim the welcome promotion and place your 2021 NFL bets for Week 1 games.)

Note: The Green Bay Packers at New Orleans Saints game is not listed with odds and lines yet, due to the uncertainty at quarterback for both teams, especially for the Packers and Aaron Rodgers.


Check our full thread of NFL betting picks for more 2021 NFL futures bet tips, 2021 NFL bet picks, NFL sleepers and more.


Early 2021 NFL Week 1 Odds & Lines

Thursday Night Football

Dallas Cowboys @ Tampa Bay Buccaneers Odds & Lines

  • Cowboys @ Buccaneers Moneyline: Cowboys +6.5 (-110), Buccaneers -6.5 (-110)
  • Cowboys @ Buccaneers ATS: Cowboys +6.5 (-110), Buccaneers -6.5 (-110)
  • Cowboys @ Buccaneers Over/Under: Over 52.5 (-110), Under 52.5 (-110)

Sunday Early Games For Week 1

Philadelphia Eagles @ Atlanta Falcons Week 1 Odds & Lines

  • Eagles @ Falcons Moneyline: Eagles (+165), Falcons (-200)
  • Eagles @ Falcons ATS: Eagles +3.5 (-110), Falcons -3.5 (-110)
  • Eagles @ Falcons Over/Under: Over 47 (-110), Under 47 (-110)

Pittsburgh Steelers @ Buffalo Bills Week 1 Odds & Lines

  • Steelers @ Bills Moneyline: Steelers (+225), Bills (-275)
  • Steelers @ Bills ATS: Steelers +6.5 (-110), Bills -6.5 (-110)
  • Steelers @ Bills Over/Under: Over 51 (-110), Under 51 (-110)

Minnesota Vikings @ Cincinnati Bengals Week 1 Odds & Lines

  • Vikings @ Bengals Moneyline: Vikings (-160), Bengals (+130)
  • Vikings @ Bengals ATS: Vikings -3 (-110), Bengals +3 (-110)
  • Vikings @ Bengals Over/Under: Over 47.5 (-110), Under 47.5 (-110)

San Francisco 49ers @ Detroit Lions Week 1 Odds & Lines

  • 49ers @ Lions Moneyline: 49ers (-400), Lions (+310)
  • 49ers @ Lions ATS: 49ers -7.5 (-110), Lions +7.5 (-110)
  • 49ers @ Lions Over/Under: Over 46 (-110), Under 46 (-110)

Arizona Cardinals @ Tennesee Titans Week 1 Odds & Lines

  • Cardinals @ Titans Moneyline: Cardinals (+115), Titans (-140)
  • Cardinals @ Titans ATS: Cardinals +2.5 (-110), Titans -2.5 (-110)
  • Cardinals @ Titans Over/Under: Over 51.5 (-110), Under 51.5 (-110)

Seattle Seahawks @ Indianapolis Colts Week 1 Odds & Lines

  • Seahawks @ Colts Moneyline: Seahawks (+115), Colts (-140)
  • Seahawks @ Colts ATS: Seahawks +2.5 (-110), Colts -2.5 (-110)
  • Seahawks @ Colts Over/Under: Over 52.5 (-110), Under 52.5 (-110)
Early 2021 NFL Week 1 Odds & Lines: ATS, Moneyline & Over/Unders For Each Scheduled Matchup

Russell Wilson and DK Metcalf lead the Seattle Seahawks for a road matchup with the Indianapolis Colts. Early 2021 NFL Week 1 Odds list Seattle-Indy with one of the highest point totals at 52.5. (Image: USA TODAY Sports)


Los Angeles Chargers @ Washington Football Team Week 1 Odds & Lines

  • Chargers @ WFT Moneyline: Chargers (-115), WFT (-105)
  • Chargers @ WFT ATS: Chargers -1 (-110), WFT +1 (-110)
  • Chargers @ WFT Over/Under: Over 45 (-110), Under 45 (-110)

New York Jets @ Carolina Panthers Week 1 Odds & Lines

  • Jets @ Panthers Moneyline: Jets (+175), Panthers (-225)
  • Jets @ Panthers ATS: Jets +4.5 (-110), Carolina -4.5 (-110)
  • Jets @ Panthers Over/Under: Over 43.5 (-110), Under 43.5 (-110)

Jacksonville Jaguars @ Houston Texans Week 1 Odds & Lines

  • Jaguars @ Texans Moneyline: Jaguars (-125), Texans (+105)
  • Jaguars @ Texans ATS: Jaguars -1.5 (-110), Texans +1.5 (-110)
  • Jaguars @ Texans Over/Under: Over 46 (-110), Under 46 (-110)

Sunday Late Games For Week 1

Cleveland Browns @ Kansas City Chiefs Week 1 Odds & Lines

  • Browns @ Chiefs Moneyline: Browns (+210), Chiefs (-275)
  • Browns @ Chiefs ATS: Browns +6 (-110), Chiefs -6 (-110)
  • Browns @ Chiefs Over/Under: Over 53.5 (-110), Under 53.5 (-110)

Miami Dolphins @ New England Patriots Week 1 Odds & Lines

  • Dolphins @ Patriots Moneyline: Dolphins (+110), Patriots (-130)
  • Dolphins @ Patriots ATS: Dolphins +2 (-110), Patriots -2 (-110)
  • Dolphins @ Patriots Over/Under: Over 46 (-110), Under 46 (-110)

Denver Broncos @ New York Giants Week 1 Odds & Lines

  • Broncos @ Giants Moneyline: Broncos (-115), Giants (-105)
  • Broncos @ Giants ATS: Broncos -1 (-110), Giants +1 (-110)
  • Broncos @ Giants Over/Under: Over 42.5 (-110), Under 42.5 (-110)

Sunday Night Football Week 1 Odds & Lines

Chicago Bears (+260) @ Los Angeles Rams Week 1 Odds & Lines

  • Bears @ Rams Moneyline: Bears (+260), Rams (-350)
  • Bears @ Rams ATS: Bears +7 (-110), Rams -7 (-110)
  • Bears @ Rams Over/Under: Over 45.5 (-110), Under 45.5 (-110)

Monday Night Football Week 1 Odds & Lines

Baltimore Ravens @ Las Vegas Raiders Week 1 Odds & Lines

  • Ravens @ Raiders Moneyline: Ravens (-330), Raiders (+240)
  • Bears @ Rams ATS: Bears +7 (-110), Rams -7 (-110)
  • Bears @ Rams Over/Under: Over 45.5 (-110), Under 45.5 (-110)

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