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UFC 322 Predictions | Della Maddalena vs Makhachev Fight Picks

Last Updated: Nov 14, 2025

The World’s Most Famous Arena, Madison Square Garden, will host UFC 322 on Saturday, November 15.

With a stacked card that features a welterweight title bout between Jack Della Maddalena and Islam Makhachev and a women’s flyweight title fight between Valentina Shevchenko and Zhang Weili, the event promises high-stakes action and intense battles that could shift the UFC landscape.

Let’s break down the UFC 322 card and pick out some of my UFC fight predictions for Saturday night’s showcase.

UFC betting lines used for these predictions are current as of Friday, Nov. 14, and courtesy of DraftKings Sportsbook.

UFC 322 Main Event Odds

To Win: Jack Della Maddalena (+245) • Islam Makhachev (-305)

Despite entering this title bout with the welterweight belt, Jack Della Maddalena is a significant underdog against challenger Islam Makhachev.

Della Maddalena (18-2) claimed the belt in May with a victory by unanimous decision over Belal Muhammad. This fight will be his first chance to defend the welterweight title.

Makhachev (27-1) is a champion in his own right, having held the lightweight belt since October 2022. The Russian fighter relinquished the belt in May after four successful title defenses to go up a weight class.

As the odds indicate, Makhachev is a sizable favorite.

UFC 322 Card & Schedule

UFC 322 will feature 13 fights in all.

The early prelims are scheduled to begin at 6 p.m. ET, the prelims will start at 8 p.m., and the main card kicks off at 10 p.m.

Below is a list of the full UFC 322 fight card:

Edit
Weight ClassUFC 322 Lineup
Welterweight (Title)Jack Della Maddalena vs. Islam Makhachev
Women's Flyweight (Title)Valentina Shevchenko vs. Zhang Weili
WelterweightSean Brady vs. Michael Morales
WelterweightLeon Edwards vs. Carlos Prates
LightweightBeneil Dariush vs. Benoit Saint-Denis
MiddleweightBo Nickal vs. Rodolfo Vieira
MiddleweightRoman Kopylov vs. Gregory Rodrigues
Women's FlyweightErin Blanchfield vs. Tracy Cortez
BantamweightMalcolm Wellmaker vs. Cody Haddon
MiddleweightKyle Daukaus vs. Gerald Meerschaert
FeatherweightPat Sabatini vs. Chepe Mariscal
Women's StrawweightAngela Hill vs. Fatima Kline
MiddleweightBaisangur Susurkaev vs. Eric McConico

UFC 322 Main Event Prediction

Islam Makhachev defeats Jack Della Maddalena by Submission (+175)

Instead of backing Makhachev to win outright at -305 odds, I’m taking the former lightweight champ to win by submission.

Makhachev has submitted 48% of his opponents, and while Della Maddalena displayed his defensive abilities against Muhammad to win the belt, the Russian is a different challenge altogether.

Take this method-of-victory prop as one of your best UFC bets today.

UFC 322 Undercard Best Bets

Valentina Shevchenko vs Zhang Weili: Fight Won by Unanimous Decision: Yes (-115)

This women’s flyweight title bout could be the best fight of the night.

It’s also another instance of a champion of one weight class, Zhang Weili, moving up a division to challenge the champion of another.

As a result, we’re seeing two fighters with relatively even odds, and both are getting love across UFC expert picks.

Instead of picking a side from the outset, I’ll bet that one of these women distinguishes themselves enough over five rounds to win by unanimous decision.

Sean Brady Defeats Michael Morales (-130)

This welterweight clash is also difficult to call.

Morales boasts an unblemished 18-0 record with 13 knockouts, but Brady could provide a problem for the Ecuadorian with his wrestling.

At 18-1, the 32-year-old American is no slouch, either, and he has a bit more experience than Morales on these grand stages.

UFC 322 Prelims Best Bets

Bo Nickal Defeats Rodolfo Vieira (-198)

Nickal is coming off his first loss, a second-round knockout against Reiner de Ridder, but I’m expecting him to bounce back against Rodolfo Vieira.

The former wrestling champion at Penn State is younger and has a size and reach advantage over the Brazilian, who has lost three of his last seven fights.

Wager on all the UFC prelims action with our DraftKings UFC promo.

Gregory Rodrigues vs Roman Kopylov: Over 1.5 Rounds (-154)

Rounding out my UFC picks for tonight, I’m backing Gregory Rodrigues and Roman Kopylov to reach Round 2.

This wager is a risk considering both fighters record the majority of their wins by knockout. However, Kopylov has had just one of his 18 career fights end inside of five minutes, while Rodrigues has reached Round 2 in 12 of 23 matchups.

Author

John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

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