Welcome to the 2025 NFL season. On this page, we’ll provide some of our best bets for each week.
Week 1 is always a challenge because we’re still feeling out each team. We often see unpredictable results here. Just think back to last season, when the Bengals lost in Week 1 against the Patriots at home.
With that in mind, find out where I’m leaning in my Week 1 NFL predictions.
Note: NFL betting information used in these best football bets are current as of Friday, September 5, 2025, at DraftKings Sportsbook
NFL Week 1 Predictions
Commanders -6 (-108) vs Giants
DraftKings Sportsbook • WAGER: 1 unit
My first pick in Week 1 predictions focuses on the Commanders -6 vs the Giants.
We’re getting below the key number of seven in a winnable game at home vs one of the worst teams in the NFC. While the Giants are improved with Russell Wilson under center, it’s hard to see them keeping it close against the Commanders.
Washington has significantly bolstered their offensive line this offseason, trading for Laremy Tunsil and using a first-round pick on Josh Conerly Jr.
Meanwhile, the Giants are going to be playing without left tackle Andrew Thomas, who is by far their best offensive lineman. That will make a huge impact in this huge matchup, giving the edge to the Commanders.
Steelers/Jets Under 37.5 Points (-105)
DraftKings Sportsbook • WAGER: 1 unit
The next pick is on a projected low-scoring game between the Steelers and Jets.
While this is already baked into the line at 37.5 points, I’m betting that Pittsburgh’s defense causes problems for Justin Fields, who is adapting to a new offense.
The Jets will be playing without Alijah Vera-Tucker, who is one of their best offensive linemen, which could make it tough to run the ball effectively.
The jury is still out on Aaron Rodgers in Pittsburgh as well. This has the look of a 17-13 type of game.
Lions ML (+124) at Packers
DraftKings Sportsbook • WAGER: 1 unit
I’ll finish it off with the Lions to knock off the Packers.
There’s a lot of hype on Green Bay, especially after they traded for one of the best defensive players in the NFL in Micah Parsons.
Conversely, there’s not a lot of buzz on the Lions, especially after they lost their two stud defensive coordinators in Ben Johnson and Aaron Glenn.
But I’m not buying that we’ll see much of a drop-off in Detroit. After all, their defense is healthy now — Aidan Hutchinson is back.
Look for the Lions to reclaim their spot among the NFL’s elite with a statement win here.
