49ers vs Rams Predictions | NFC Championship Pick of the Day

The NFC West will have two teams in the NFC Championship game this Sunday.

In the Divisional Round, the Los Angeles Rams upset the Tampa Bay Buccaneers in stunning fashion, after almost blowing a three-score lead. San Francisco found a way to defeat the Green Bay Packers with some big plays on special teams.

The 49ers finished as the sixth seed in the NFC, but they’ve already defeated the Rams twice this season. Their fan base travels well, but the Rams are pulling ticket sales shenanigans to try to block them from attending the game in Los Angeles.

Could this finally give the Rams the advantage they need over the 49ers?

Let’s dive in with our 49ers vs Rams predictions and best bets to find out.

Please note that all NFL Playoffs odds and lines are current as of 9 a.m. ET on Tuesday, January 25.

49ers vs Rams Prediction NFC Championship Playoffs

The 49ers have had the Rams’ number this season. In the first game between these two teams, the 49ers defeated the Rams, 31-10.

Quarterback Jimmy Garoppolo didn’t have to do much to help secure the victory, throwing for 182 yards and two touchdowns. Rams QB Matthew Stafford threw two interceptions, and the Los Angeles running game struggled big-time against the 49ers.


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Their second matchup resulted in another stunning loss for the Rams. The Rams lost at home in overtime, allowing the 49ers to clinch a playoff berth. Again, Stafford threw two interceptions while the running game struggled.

Both of these teams have been very good offensively and defensively this season. The 49ers haven’t been all that great defensively against the run, but they have had their way against the Rams.

The Rams have been much better at stopping the run but will be facing a 49ers team that loves to run the football. Running back Elijah Mitchell came close to 100 yards in each of those two games he faced the Rams, carrying the ball a total of 48 times across those two contests.

Of course, Deebo Samuel has been a revelation when working out of the backfield, which has added a much-needed X-factor to San Fran’s otherwise erratically exciting offense. George Kittle typically presents matchup problems, too.

However, despite the 49ers’ tough secondary, they’ll struggle to stop Cooper Kupp, who’s on fire right now.

We’ve already seen two relatively high-scoring games between the Rams and 49ers, but while both teams are coached by great offensive minds, the Rams have superior talent. The advantage stands out along the line of scrimmage, notably when on defense with Aaron DonaldVon Miller, and Leonard Floyd, who should make Garoppolo uncomfortable and could force a game-breaking turnover or two.

NFC Championship Game Prediction: Rams 20, 49ers 13

Elijah Mitchell, San Francisco 49ers RB, scores a touchdown in 2021 Week 1

Elijah Mitchell (pictured) and Deebo Samuel have been a dynamic rushing combo, and their success might be the 49ers’ best hope to topple the Rams in the 2022 NFC Championship Game. (Image: USA TODAY Sports)


49ers vs Rams Best Bets

Best Bet: Rams -3.5 (-110) at Caesars

Rams-49ers Wager: 1 Unit

Just like last week’s games, you can expect a close one between these two teams. The 49ers haven’t looked all that special on offense in the playoffs. In the Wild Card game, Jimmy Garopppolo threw for 172 yards while Elijah Mitchell ran for 86 yards on 27 carries.

Against the Packers, the 49ers struggled to make plays again, with Jimmy Garopplolo throwing just 11 completions the entire game. The special teams unit played a big role against the Packers, but bettors can’t count on that type of luck once again versus the more disciplined Rams.

The Rams boast the more prolific offense, and while they tried to find every way possible to lose that game against the Bucs, they were able to make a couple of plays in the end to secure the victory. That’ll happen in this one as well.

Take Los Angeles for our NFL bet of the day.

spread

-110

Rams: Cover -3.5 Spread vs 49ers

SF @ LA | 01/30, 6:30 PM ET

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Check out more of our 49ers vs Rams Predictions


Best Bet: UNDER 46 Total Points (-110) at Caesars

Rams-49ers Wager: 1 Unit

The 49ers had their way against Aaron Rodgers last week. While I don’t think Matthew Stafford will be as puzzled with all the talent he has around him, the 49ers will limit him when it counts.

They held the Rams to 10 points in their first matchup and 24 points in their second one. The rushing defense has been solid against the Rams, which should help the 49ers get some stops.

Meanwhile, the Rams look electric defensively. Sure, they had a hiccup against Tom Brady and the Buccaneers, but seemingly, every team does. Remember, the Rams held the Buccaneers to just three points halfway through the third quarter of last week’s game.

I’m expecting enough defense to be played in this game to keep the total Under.

over-under

-110

49ers @ Rams: UNDER 46 Points

SF @ LA | 01/30, 6:30 PM ET

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Schedule & Odds

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NFL Betting News

  • Early money slightly leaning towards the over in the 49ers-Rams matchup

    DraftKings Sportsbook is reporting good two-way action on the over/under for the NFC Championship Game matchup between the San Francisco 49ers and Los Angeles Rams.

    Betting Impact:
    Per DraftKings, the over of 46 points has attracted 55% of the bets and 60% of the money thus far. Much moreso than the AFC Championship Game, the betting splits on the point spread and total in this game are much more evenly split, so the sportsbook does not have too much liability on either at the moment. From a moneyline perspective, Los Angeles's -170 moneyline odds have attracted 60% of the bets and 70% of the money.

    SF vs. LAR Game Page

  • Early bettors give slight lean to the Rams over the 49ers

    Based on the betting splits at DraftKings Sportsbook, the favored Los Angeles Rams are getting slightly more betting attention in their matchup with the San Francisco 49ers.

    Betting Impact:
    Per DraftKings, Los Angeles's -3.5 point spread has received 65% of the bets and 61% of the handle thus far. Bettors are clearly torn in this matchup considering the Rams have arguably been playing better football through the first two playoff games, while the 49ers have won six consecutive games against the Rams, including a thrilling Week 18 overtime victory in Los Angeles.

    SF vs. LAR Game Page

  • Early money more than 4/1 on the over in the Bengals-Chiefs matchup

    DraftKings Sportsbook is reporting one-sided betting action for Sunday's over/under in the matchup between the Cincinnati Bengals and Kansas City Chiefs.

    Betting Impact:
    Per DraftKings, the over of 54.5 points has attracted 75% of the bets and 85% of the money thus far. At this point, the sportsbook has big liability to the Chiefs point spread and the over in this matchup, as their most ideal scenario would be a Bengals cover in a low-scoring game at the moment. From a moneyline perspective, Kansas City's -335 moneyline odds have attracted 58% of the bets and 61% of the money.

    CIN vs. KC Game Page

  • Early money 3/1 on the Chiefs over the Bengals

    DraftKings Sportsbook is reporting one-sided betting action for Sunday's matchup between the Cincinnati Bengals and Kansas City Chiefs, as the majority of the action is backing the favored Chiefs.

    Betting Impact:
    Per DraftKings, Kansas City's -7 point spread has received 61% of the bets and 76% of the handle thus far. Cincinnati is shaping up to be the biggest need of any side or any total this weekend, as the public seems to be enamored with the Chiefs after their thrilling Divisional Round win over Buffalo.

    CIN vs. KC Game Page

  • 49ers-Rams over/under reaches lowest number of the week

    After another line movement, the over/under for the NFC Championship matchup between the San Francisco 49ers and Los Angeles Rams has reached its lowest total of the week.

    Betting Impact:
    Per DraftKings, the 49ers-Rams over/under on Sunday night was posted at 47.5 points. It was quickly bet down to 46.5 in less than 24 hours. However, it has once again moved toward the under, and now currently sits at 46 points. Given that there has not yet been buyback on the over, it is extremely unlikely we see the total get back to anywhere close to the 47.5 points it opened at.

    SF vs. LAR Game Page