Rams vs Giants Predictions Week 6 | NFL Pick of the Day

Last Updated: Oct 15, 2021

The 4-1 Los Angeles Rams will travel to the meadowlands this week to take on the 1-4 Giants. Given the team’s respective records, the Rams have opened as double-digit favorites.

However, the Giants have been frisky, beating New Orleans and coming up short of wins against Atlanta and Washington. While Saquon Barkley is almost certainly out, the big question surrounds Daniel Jones, who may be out with a concussion.

If Mike Glennon does start, do the Giants potentially pose value as big home underdogs, or are they auto-fades against a loaded Rams roster?

Let’s dig into this matchup. Please note that all Rams vs Giants odds and lines are current as of 4 PM EST on Friday, October 15.

Sportsbook Play of the Day

Before you make your Rams vs. Giants bet picks, you should know that Caesars Sportsbook is among the industry’s best, offering tons of promotions and a fantastic $5,000 risk-free welcome bonus to new signups using our promo code .

Read Chris Wassel’s Caesars Sportsbook review for more insight and get your welcome bonus below, or continue reading this analysis for our Rams vs. Giants best bets.

Rams vs. Giants Prediction

Unfortunately, the Giants are simply too banged up to compete with a team like the Rams.

Outside of Barkley and Jones, these are the players currently on the Giants injury list:

  • G Shane Lemieux
  • G Ben Bredeson
  • T Andrew Thomas
  • C Nick Gates
  • WR Sterling Shepard
  • WR Darius Slayton
  • DB Keion Crossen
  • LB Tae Crowder
  • LB Cam Brown
  • SS Jabrill Peppers

While there are reasons to back the Giants week-by-week, there’s no way they compete in this game. Especially since the Rams are coming off a tough loss, as Sean McVay is 11-5 against the spread (ATS) off of a loss.

The Rams boast a loaded roster, and I believe they’ll pick up a wire-to-wire victory this week.

Prediction: Rams 35, Giants 13

Aaron Donald, DT, Los Angeles Rams

With the New York Giants offense filled with injuries, Aaron Donald and the Los Angeles Rams defense look to have a big day in Week 6. (Image: USA TODAY Sports)

Rams vs. Giants Best Bets

Best Bet: Rams -8.5 (-110) at Caesars

Wager: 1 Unit

I don’t think the Giants find a rhythm at all.

With Jones under center and Barkley lining up behind him, the Giants rank at 21st in PFF’s offense grades, including 32nd in PFF’s rush grades.

Now, without Jones or Barkley, New York has to face a Los Angeles defense that ranks fourth in PFF’s defensive grades and first in PFF’s rush grades. With half of an offensive line, no quarterback, and no Barkley, there’s no way the Giants move the ball.

Meanwhile, Matthew Stafford has looked shaky at times, but he still ranks first among NFL quarterbacks in estimated points added per play.

Throughout the first 5 weeks of the season, Stafford is one of the top quarterbacks in the NFL in Quarterback Efficiency. (Courtesy of

Plus, Stafford has the seventh-highest adjusted completed percentage on throws 20+ yards downfield. This Rams offense has a dynamic, explosive component to it that the Giants offense will be missing without Jones on the field.

As I write above, this game will be a wire-to-wire blowout in favor of the Rams.

Best Bet: Rams Team Total Over 29.5 (-110) at BetMGM

Wager: 0.5 Units

The Giants’ defense is frisky but not very efficient.

The Giants and Rams defenses are virtually the same when it comes to the rush, but the Giants are allowing more estimated points added per play on dropbacks. (Courtesy of

On the season, New York is allowing nearly 28 points per game. That includes 44 to the Giants and 30 to Washington.

As mentioned, the Rams boast a dynamic and explosive offense. The Giants already rank 23rd in PFF’s coverage grades, and the defense now has zero shot against the Rams with their injuries.

I’m really high on the Rams in this game, and I’m willing to make a smaller-sized play on their team total as a result.

Tanner McGrath’s 2021 NFL Betting Record: 5-9, -2.8 Units

Thank you for reading our NFL Week 6 Rams vs. Giants Predictions! For more NFL betting tips, check out our NFL Week 6 Best Bets!


Tanner McGrath

Tanner McGrath joined The Game Day to cover the NFL but is beginning to branch out in other areas as well. He can write about anything but is especially passionate about Major League Baseball (go Red Sox!) and NCAA Basketball. He’s a McGill University grad and former (Canadian) Division-I alpine ski racer who now spends his time drinking beer and betting home underdogs.

Related articles