Checking NFL early lines each week gives prospective football bettors a solid idea of trends that the sportsbooks and the public will enact for that week’s action.
To offer our NFL readers perspective, we’ve gathered some Week 4 NFL Opening Lines and Odds, including moneyline, against the spread, Over/Under, and implied total information to start your betting off right.
2021 NFL Early Lines Week 4: Opening Odds & Betting Info for NFL Games This Week
All Week 4 NFL gameday odds and lines are provided courtesy of Caesars Sportsbook, current as of 10 p.m. ET on Sunday, September 26.
Jacksonville Jaguars at Cincinnati Bengals (Thursday Night Football, 8:20 p.m. ET)
- Moneyline: Jaguars (+290), Bengals (-350)
- Spread: Jaguars +7.5 (-110), Bengals -7.5 (-110)
- Over/Under Points Total: Over 45.5 (-110), Under 45.5 (-110)
- Implied Score: Jaguars 19, Bengals 26.5
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Tennessee Titans at New York Jets (1 p.m. ET)
- Moneyline: Titans (-350), Jets (+290)
- Spread: Titans -7.5 (-110), Jets (-110)
- Over/Under Points Total: Over 46 (-110), Under 46 (-110)
- Implied Score: Titans 26.75, Jets 19.25
New York Giants at New Orleans Saints (1 p.m. ET)
- Moneyline: Giants (+320), Saints (-400)
- Spread: Giants +8 (-110), Saints -8 (-110)
- Over/Under Points Total: Over 43.5 (-110), Under 43.5 (-110)
- Implied Score: Giants 17.75, Saints 25.75
Carolina Panthers at Dallas Cowboys (1 p.m. ET)
- Moneyline: Panthers (+180), Cowboys (-210)
- Spread: Panthers +4.5 (-110), Cowboys -4.5 (-110)
- Over/Under Points Total: Over 50 (-110), Under 50 (-110)
- Implied Score: Panthers 22.75, Cowboys 27.25
Kansas City Chiefs at Philadelphia Eagles (1 p.m. ET)
- Moneyline: Chiefs (-260), Eagles (+220)
- Spread: Chiefs -6 (-110), Eagles +6 (-110)
- Over/Under Points Total: Over 55 (-110), Under 55 (-110)
- Implied Score: Chiefs 30.5, Eagles 24.5
While the Eagles still wait for Monday night to play, Patrick Mahomes and the Chiefs suffered a tough loss to the Chargers in Week 3. This is the second straight loss for Mahomes in the month of September after going 11-0.
Even coming off of a loss, the Chiefs are still the favorites heading into Philadelphia. The numbers can change based on how the Eagles do against the Cowboys, but Kansas City should still enter as the favorites.
The Chiefs have one of the most talented rosters in the NFL, so -6 is a good pick here.
Cleveland Browns at Minnesota Vikings (1 p.m. ET)
- Moneyline: Browns (-120), Vikings (+100)
- Spread: Browns -1 (-110), Vikings +1 (-110)
- Over/Under Points Total: Over 52.5 (-110), Under 52.5 (-110)
- Implied Score: Browns 26.75, Vikings 25.75
Detroit Lions at Chicago Bears (1 p.m. ET)
- Moneyline: Lions (+160), Bears (-180)
- Spread: Lions +3.5 (-110), Bears -3.5 (-110)
- Over/Under Points Total: Over 44 (-110), Under 44 (-110)
- Implied Score: Lions 20.25, Bears 23.75
Houston Texans at Buffalo Bills (1 p.m. ET)
- Moneyline: Texans (+1100), Bills (-2000)
- Spread: Texans +17.5 (-110), Bills -17.5 (-110)
- Over/Under Points Total: Over 48 (-110), Under 48 (-110)
- Implied Score: Texans 15.25, Bills 32.75
Indianapolis Colts at Miami Dolphins (1 p.m. ET)
- Moneyline: Colts (+110), Dolphins (-130)
- Spread: Colts +2 (-110), Dolphins -2 (-110)
- Over/Under Points Total: Over 43.5 (-110), Under 43.5 (-110)
- Implied Score: Colts 20.75, Dolphins 22.75
Washington Football Team at Atlanta Falcons (1 p.m. ET)
- Moneyline: Washington (-110), Falcons (-110)
- Spread: Washington +0 (-110), Falcons +0 (-110)
- Over/Under Points Total: Over 48.5 (-110), Under 48.5 (-110)
- Implied Score: Washington 24.5, Falcons 24.5
Seattle Seahawks at San Francisco 49ers (4:05 p.m. ET)
- Moneyline: Seahawks (+135), 49ers (-155)
- Spread: Seahawks +3 (-110), 49ers -3 (-110)
- Over/Under Points Total: Over 51.5 (-110), Under 51.5 (-110)
- Implied Score: Seahawks 24.25, 49ers 27.25
Arizona Cardinals at Los Angeles Rams (4:05 p.m. ET)
- Moneyline: Cardinals (+230), Rams (-270)
- Spread: Cardinals +6 (-110), Rams -6 (-110)
- Over/Under Points Total: Over 53.5 (-110), Under 53.5 (-110)
- Implied Score: Cardinals 23.75, Rams 29.75
Both the Cardinals and the Rams are coming off of impressive wins in Week 3. One team will come out of this matchup still undefeated, while the other will suffer their first loss of the season.
Kyler Murray and Matthew Stafford both lead high-powered offenses, as both teams are top 3in the NFL in points per game (Arizona 1st, Los Angeles 3rd).
Pittsburgh Steelers at Green Bay Packers (4:25 p.m. ET)
- Moneyline: Steelers (+270), Packers (-330)
- Spread: Steelers +7 (+100), Packers -7 (-120)
- Over/Under Points Total: Over 47 (-110), Under 47 (-110)
- Implied Score: Steelers 20, Packers 27
Baltimore Ravens at Denver Broncos (4:25 p.m. ET)
- Moneyline: Ravens (+105), Broncos (-125)
- Spread: Ravens +1.5 (-110), Broncos -1.5 (-110)
- Over/Under Points Total: Over 44.5 (-110), Under 44.5 (-110)
- Implied Score: Ravens 21.50, Broncos 23
While the Ravens walked away with what could be the most exciting win of the year so far, the Broncos continued to dominate their opponents in Week 3.
This will be Denver’s first real test of the season when they host Baltimore, as each of their three opponents this season is winless. Still, at -125, the Broncos are a good pick here.
Tampa Bay Buccaneers at New England Patriots (Sunday Night Football, 8:20 p.m. ET)
- Moneyline: Buccaneers (-250), Patriots (+210)
- Spread: Buccaneers -5.5 (-110), Patriots +5.5 (-110)
- Over/Under Points Total: Over 49 (-110), Under 49 (-110)
- Implied Score: Buccaneers 27.25, Patriots 21.75
Las Vegas Raiders at Los Angeles Chargers (Monday Night Football, 8:15 p.m. ET)
- Moneyline: Raiders (+145), Chargers (-165)
- Spread: Raiders +3 (+100), Chargers -3 (-120)
- Over/Under Points Total: Over 53.5 (-110), Under 53.5 (-110)
- Implied Score: Raiders 25.25, Chargers 28.25
Thanks for reading our NFL Week 4 Early Lines! For more NFL Week 4 betting tips, check out our NFL Week 4 Best Bets.
