Seahawks vs Colts NFL Week 1 Predictions: Picks, Best Bets & Parlays

The NFL season is finally here, and it’s time to lay down some wagers with the Seattle Seahawks and Indianapolis Colts.

The Seahawks head into the 2021 season with Super Bowl aspirations. This is a team with an improved offensive line and defense that really came alive in the second half of last season. The Colts are headed in the opposite direction, with new starting quarterback Carson Wentz and dominant offensive guard Quenton Nelson each banged up with foot injuries.

Let’s dive in to find out what picks of the day you should use to place a bet in the Seahawks vs Colts Week 1 NFL game.

Seattle Seahawks vs Indianapolis Colts Prediction

The Seahawks bolstered their offensive line with the addition of guard Gabe Jackson. They also have a new offensive coordinator in former Rams passing game coordinator Shane Waldron, who hopes to play at a faster pace this season. This was an offense that got stale under Brian Schottenheimer and should get off to a strong start against the Colts.


Sportsbook Play of the Day

Place a 2021-2022 NHL futures bet with DraftKings Sportsbook, who provides us with these 2022 Stanley Cup Champion odds. Claim their welcome offer: Get up to $1000 free on a first-deposit match and start betting.

To learn more about DraftKings’ features and promotions that can allow you to bet on this season’s Stanley Cup winner, read Anthony Cervino’s hands-on DraftKings Sportsbook review.

DraftKings Sportsbook

DraftKings Sportsbook

  • Huge Variety of US & International Markets

  • Tons of Promotions & Features

  • VIP & Rewards System

Get up to $1,000 Free

First Deposit Match

No code requiredGet bonus

New Customers Only, 21+. T&C’s Apply.


The Colts came into the season as playoff contenders, but Carson Wentz and Quenten Nelson are currently nursing foot injuries. It’s going to be difficult for them to keep pace in this game with a limited Wentz. We can expect a run-heavy approach.

The Seahawks pass-rush, led by Carlos Dunlap, should be able to have a field day in this game. The Colts won’t be able to keep pace with this high-octane Seahawks offense. (Keep tabs of other betting opportunities for this game with our NFL gameday odds page.

Prediction: Seattle Seahawks 31, Indianapolis Colts 14

Seattle Seahawks vs Indianapolis Colts Best Bets

Best Bet: Seahawks -3 (-110)

spread

-110

Seahawks To Cover -3 @ Colts (NFL Week 1)

SEA @ IND | 09/12, 1:00 PM ET

BetMGM Sportsbook Welcome OfferGet Up To $1,000 Risk-Free
Bet MGM Logo

Bet $20, Payout $38

The NFL bet of the day for this game is easy: Seahawks should be able to win this game by a touchdown or more with such an advantage at quarterback. The Colts offensive line will have a tough time with the Seahawks pass-rush, making it difficult to keep pace with an offense that projects as one of the best in the NFL.

Take advantage of the low spread due to the Colts home-field advantage. If this game was in Seattle, you would likely see the Seahawks as -7.5 to -9 point favorites. The Colts would need to win the turnover battle with their defense playing at an elite level to win this game. Ride with Wilson here, don’t overthink this one.

Best Bet: Under 49.5 (-110)

over-under

-110

Seahawks vs. Colts: Under 49.5 Points (SEA @ IND, NFL Week 1)

SEA @ IND | 09/12, 1:00 PM ET

BetMGM Sportsbook Welcome OfferGet Up To $1,000 Risk-Free
Bet MGM Logo

Bet $20, Payout $38

Even with Wentz back, it’s tough for the Colts to put enough points to help this total go over the number. This is a quarterback who was one of the worst in the NFL last season. You’re going to see the Colts go with a conservative approach on offense, which means short passes and handoffs to Jonathan Taylor. The Colts will play at a slow pace to try to keep the Seahawks off the field.

The Seahawks defense was a much-improved unit once they traded for pass-rusher Carlos Dunlap last season. They should be able to shut down this run-heavy Colts offense. We could see the Seahawks slow the game down in the second half with their running game if they’re up by multiple scores, which appears likely and bodes well for the under.

Seattle Seahawks vs Indianapolis Colts Same Game Parlay Picks

prop bet

+250

Seahawks vs. Colts: Seahawks -3.5 and Under 47.5 Points (SEA @ IND, NFL Week 1)

SEA @ IND | 09/12, 1:00 PM ET

BetMGM Sportsbook Welcome OfferGet Up To $1,000 Risk-Free
Bet MGM Logo

Bet $20, Payout $70

The Seahawks and the Under have a strong correlation because it’s unlikely that the Colts will be able to score many points against this defense with a limited Wentz at quarterback. The Seahawks would likely need to score 35+ points for this game to go over the total.

We could see the Seahawks get off to a quick start before taking their proverbial foot off the gas and pounding the ball with running backs Chris Carson and Rashaad Penny in the second half. It’s best to keep it simple here: Take advantage of mediocre quarterback play for the Colts and ride with the under.

Seahawks -3.5

Seahawks/Colts Under 47.5

Related articles

Promotions

Welcome offer Caesars Sportsbook promotion

Get Up To $1,500 FREE

5 stars
Welcome offer BetMGM Sportsbook promotion

Get Up To $1,000 Risk-Free

5 stars
Welcome offer BetRivers Sportsbook promotion

Get Up To $250 Free

5 stars
Welcome offer Betway Sportsbook promotion

Get Up To $250 Risk Free Bet

5 stars

Schedule & Odds

Top Offers

NBA Betting News

  • Celtics +300 to win NBA Title

    The Boston Celtics are +300 to win the 2021-22 NBA Championship, per BettingPros consensus odds.

    Betting Impact:
    The Celtics are +300 ahead of their home date with the Warriors for Game 6. We will see a considerable odds shift if the Celtics can win Game 6 on their homecourt. Boston was +310 after Game 5.

  • Celtics vs. Warriors over/under listed at 210

    The over/under for Game 6 of the NBA Finals between the Boston Celtics and the Golden State Warriors is listed at 210, per BettingPros consensus odds.

    Betting Impact:
    The total for this contest sits at 210, down from the 210.5 it opened at. 60 percent of the public action has come on the over.

  • Warriors -400 to win NBA Championship

    The Golden State Warriors are -400 to win the NBA Championship, per BettingPros consensus odds.

    Betting Impact:
    Golden State now sits at a prohibitive -400 to win the NBA Championship. For comparison, Stephen Curry MVP is -360. Andrew Wiggins, the dark horse to steal the award with a big close-out game, sits at +2000.

  • Celtics +310 to win NBA Championship

    The Boston Celtics are +310 to win the 2021-22 NBA Championship, per BettingPros consensus odds.

    Betting Impact:
    The Celtics peaked as high as high as -230 prior to Game 3 and now sit at an attractive +310. Boston entered the season at +4000. The odds could swing wildly again if Boston wins Game 6.

  • Warriors vs. Celtics over/under listed at 210.5

    The over/under for Game 5 of the NBA Finals between the Golden State Warriors and the Boston Celtics is listed at 210.5, per BettingPros consensus odds.

    Betting Impact:
    The total for this contest sits at 210.5, down from the 212.5 it opened at. 72 percent of the public action has come on the over.