We’re onto Week 5 of the 2025 NFL season. Now that we have a four-game sample, we’re starting to get a good idea of contenders and pretenders, especially with injuries mounting across the league.
This page highlights my best football parlay bet for Week 5, along with a longshot parlay and Same Game Parlay.
We’ll try to make it a winning week with my NFL Week 5 parlays, so let’s dive in.
Best NFL Week 5 Parlay
All NFL gameday odds are current as of Friday, Oct. 6, at 11 a.m. ET from the indicated sportsbook.
Week 5 Top Parlay (+261)
DraftKings Sportsbook • WAGER: 1 Unit
- Broncos/Eagles Under 43.5 (-112)
- Titans/Cardinals Under 42.5 (-110)
The top parlay features two Unders in projected low-scoring games.
We’ll start with Broncos/Eagles Under 43.5. Denver will have a tough time with an elite Eagles defense. But more so, this is about the Eagles’ struggles on offense, both through the air and on the ground. We just saw them win a game where Jalen Hurts didn’t even complete a pass in the second half.
I like getting above the key number of 43 with this Under, which means that we’d win in a 23-20 score line.
I’ll finish it off with Titans/Cardinals Under 42.5. Tennessee has been abysmal on offense, coming off a game where they got shut out by the Texans. Rookie quarterback Cam Ward is having difficulty transitioning to the NFL. We’re unlikely to see much improvement vs an underrated Cardinals defense.
We also should acknowledge that Arizona is playing without James Conner and Trey Benson, so their offense could be one-dimensional here.
Target these two Unders in our NFL bet of the day.
Longshot NFL Week 5 Parlay
Week 5 Longshot Parlay (+475)
DraftKings Sportsbook • WAGER: 0.5 Units
- Browns ML (+185) vs Vikings
- Ravens ML (+102) vs Texans
The longshot parlay features two underdogs on the moneyline.
I’ll start with the Browns, who have one of the best front-sevens in the NFL, highlighted by Myles Garrett. That’s bad news with turnover-prone Carson Wentz under center, taking snaps behind an injury-plagued offensive line. Expect Wentz to be under constant duress.
Cleveland has also made a change at quarterback, going with fourth-round rookie Dillon Gabriel. This is a mobile signal-caller who can extend plays with his legs. That’s exactly what the Browns need to ignite their lethargic offense.
I’ll finish this parlay with the Ravens, who are home underdogs against the Texans because Cooper Rush is forced to start for the injured Lamar Jackson. But let’s remember that Rush kept the Cowboys in games last year, so it’s not like this is a backup without starting experience.
Given the Texans’ struggles on offense, I’ll take a shot on the Ravens coming through with a team win here.
NFL Week 5 Same Game Parlay
Giants vs Saints Same Game Parlay (+278)
DraftKings Sportsbook • WAGER: 1 Units
- Giants ML (+102)
- Over 42.5 Points (-105)
The Week 5 Same Game Parlay focuses on Giants vs Saints.
I’ll start with the Giants moneyline. Even without Malik Nabers, this is a much different team with Jaxson Dart under center. This is a playmaking gunslinger who adds another dimension to this offense. We saw the G-Men come through with an impressive win against the Chargers. Bet on them taking care of business vs the Saints.
I’ll add the Over 42.5 points. For one, we’re getting below the key number of 43, so we win with a 23-20 result. On top of that, the Saints have played at a fast pace under first-year head coach Kellen Moore, which bodes well for the Over.
