Giants vs Titans Predictions | Best Bets & Odds

Last Updated: Sep 7, 2022

The Brian Daboll era will open for the New York Giants when the rookie coach takes his team to Nashville for a Week 1 date against the Tennessee Titans.

Daboll, the former Buffalo Bills offensive coordinator, will be New York’s fifth coach in the past seven seasons since legendary coach Tom Coughlin resigned after the 2015 campaign. The Giants are coming off a 4-13 season where they finished last in the NFC East for the third time in the past five years and have not made the playoffs since 2016.

The Titans have won the AFC South in consecutive seasons and have made the playoffs three straight years. Tennessee was the top seed in the AFC in 2021 but was picked off by the eventual AFC champion Cincinnati Bengals, 19-16, in the divisional round.

Giants vs Titans Odds

Unsurprisingly, the locked-and-loaded Titans are more than a touchdown favorite against the new-look Giants. The Titans have become one of the most consistent teams in the AFC under head coach Mike Vrabel, and New York is 22-59 since 2017.

Take a look at the best Giants odds and Titans odds for the 2022 NFL season.

Giants vs Titans Implied Score

Titans 24, Giants 18.5

The Titans averaged about 24.6 points per game in 2021, which checks out. The Giants only scored about 15 points per game a year ago but averaged 18.4 points per game with Daniel Jones as the starting quarterback in 2021.

Giants vs Titans Pick of the Day

Read more on this Giants vs Titans bet below.

Giants vs Titans Matchup

Titans star running back Derrick Henry is one of the most difficult backs to bring down, and New York ranked just 25th against the run in 2021. The Giants are hoping rookie edge rusher Kayvon Thibodeaux eventually evolves into a game-wrecking force, but the Titans and quarterback Ryan Tannehill run the sort of misdirection and trickery that gets inexperienced defenses all mixed up, especially with the addition of wide receiver/running threat Robert Woods, who the Titans acquired from the Rams during the offseason.

The jury is out on Jones as the New York starting quarterback, especially as he gets set to embark on his third different offense in four years. Jones and embattled running back Saquon Barkley will have a tall order going against the sixth-ranked defense in 2021 that was 12th in yards per game allowed (329.8) and surrendered the second-fewest rushing yards in football a year ago (84.6 per game).

Giants vs Titans Prediction

Titans 28, Giants 13

The Giants haven’t won their season-opening game since 2016, and are just 1-10 in their past 11 opening games dating back to 2010. Jones has had trouble protecting the ball in his three seasons as Giants quarterback, and this is a matchup nightmare for them as a young team with a rookie coach and an inexperienced offensive line. Tennessee was tied for ninth in the NFL in sacks (43), led by Pro Bowler Harold Landry‘s 12.

Plus, Titans fans, who are undoubtedly still stinging from their team’s shocking playoff exit, should be good and ready to wreak havoc on New York’s offense given the fact this game will air in a late-TV window.

The Titans offense should also be a problem against the Giants’ defense. Despite the fact Tennessee traded star receiver A.J. Brown to the Philadelphia Eagles, it still has Henry, the 2020 NFL Offensive Player of the Year who missed nine games with a broken bone in his foot in 2021, who is hungry to prove to doubters that he’s still got a lot left in the tank.

Barkley, who was one of the most dynamic backs in football when he amassed more than 2,000 all-purpose yards from scrimmage as a rookie in 2018, had a hard time rebounding from a knee injury he sustained early in the 2020 season. He finished with fewer than 1,000 total yards and just four touchdowns in 2021 as opponents keyed on him and his offensive line struggled to open holes for him.

Giants vs Titans Bet Tips

Tennessee was 6-3 against the spread in home games in 2021. New York was 3-6 on the road against the spread and 6-11 against the line overall. The Giants have started 0-2 in each of their past five seasons and are 2-8 against the spread in those games. The Titans are 1-3 in home openers against NFC opponents since moving from Houston in 1996.

Giants vs Titans Best Bets

Titans -5.5 (-110) at Caesars Sportsbook

Wager: 1 Unit

It would be very stunning if the Titans sleepwalked through their opener against the Giants. Barring a dramatic uprising from the Giants, Henry and the Titans should be able to win relatively handily.

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Under 43.5 Points (-110) at Caesars Sportsbook

Wager: 1 Unit

We are loathed to recommend betting an Under and a favorite to cover the spread, lest one wager cancels out winning the other, but it’s hard to see the Giants offense doing much against Tennessee’s vaunted defense. Daboll should get New York’s offense uncorked at some point, but it probably won’t be in Week 1.

Giants vs Titans Props

Derrick Henry: Over 97.5 Rushing Yards (+104) at Caesars

Henry is starving after missing the final half of the season and amassing just 62 yards in Tennessee’s season-ending loss to the Bengals. He should be able to go for over 100 in his first regular-season game since Halloween.

Saquon Barkley: Under 87.5 Rushing + Receiving Yards (-110) at Caesars

Barkley didn’t surpass 88 combined yards from scrimmage in nine of the 13 games he suited up for last season. Granted, Barkley was recovering from a knee injury in 2020, and the offense Joe Judge and Jason Garrett dialed up last season wasn’t exactly doing Barkley any favors.

But given the Tennessee defense, plus the likelihood the Giants will be passing for most of the second half, we expect this under to be correct.

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Daniel Jones Over 0.5 Interceptions (-129) at Caesars

Jones did a better job of protecting the ball in 2021 but still threw seven picks in 11 games before missing the final six games due to a neck injury. He has 29 picks in 38 career games, including 10 in 13 career road starts. Given the potential for this game to get away from the Giants, and Tennessee’s ball-hawking secondary — the Titans had 22 interceptions in 2021 — a pick is likely.

Giants vs Titans Parlays

Best Same-Game Parlay (+256) at FanDuel Sportsbook

  • Titans Moneyline
  • Derrick Henry Anytime Touchdown
  • Alternate Total: Under 47.5 Points

Based on our analysis, this parlay seems pretty self-explanatory. We teased up the total just to mitigate any sort of garbage-time touchdown that enables the over to hit. We generally don’t recommend betting an under along with a team to cover a spread, but if you wanted to trust Tennessee to cover 3.5 points, the odds shoot up to (+304).


Pat Pickens

Pat Pickens is a seasoned sportswriter who has covered pro sports since 2013 for various websites, including The New York Times,, Bleacher Report,, USA Today, the Associated Press and many others. His debut book, titled "The Whalers" about the history of the NHL's Hartford Whalers, was released in October 2021.

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