Cardinals vs Rams Predictions & Odds

Last Updated: Nov 8, 2022

The Arizona Cardinals (3-6) travel to SoFi Stadium for a Week 10 clash against the division-rival, defending champion Los Angeles Rams (3-5), with both teams looking to turn around their spiraling seasons.

Both squads are coming off of Week 9 losses, as Arizona suffered a 31-21 defeat at the hands of the Seahawks, while Los Angeles fell to the Tampa Bay Buccaneers on a last-second touchdown pass, 16-13.

The Rams won the Week 3 meeting between the teams at State Farm Stadium by a 20-12 margin.

Without further ado, let’s jump into our Arizona vs Los Angeles best bets, predictions, and betting tips for Week 10.

Cardinals vs Rams Odds

The Rams’ status as three-point home favorites isn’t surprising, considering it’s still usually considered a minimum, standard figure for a host.

With neither team displaying anything remotely resembling week-to-week consistency on offense, the fact oddsmakers are playing this cautiously and have also attached a low total of 43.5 points fits with the body of work and circumstances surrounding each club.

Take a look at the best Cardinals odds and Rams odds for the 2022 NFL season.

All odds are current as of 1 p.m. ET on Tuesday, Nov. 8, at Caesars Sportsbook.

Cardinals vs Rams Implied Totals

Rams 23.25, Cardinals 20.25

Oddsmakers seem to be expecting another relatively sluggish day for both offenses, as of 1 p.m. ET on Tuesday, Nov. 8, with each team’s problems in pass protection coming to bear and the talent on either defense also making its presence felt frequently.

Cardinals vs Rams Pick of the Day

Read more on this Cardinals vs Rams bet below.

Cardinals vs Rams Prediction

Rams 24, Cardinals 20

The Rams continue to look like anything but last year’s Super Bowl-winning squad, with its porous offensive line largely to blame. Matthew Stafford has already taken 28 sacks in nine games, just two fewer than he did all of last season while suiting up in all 17 contests.

That type of pressure has naturally disrupted the entire rhythm of what was an impressive air attack in 2021, but Stafford should have a bit more time in the pocket Sunday.

The Cardinals have collected a modest 16 sacks in nine games and are tied for the league’s sixth-lowest adjusted sack rate per Football Outsiders. Stafford was brought down just once by the Cards in the Week 3 meeting between the teams and put together a solid 18-for-25, 249-yard effort through the air.

Those figures came in spite of Arizona doing a very effective job limiting Cooper Kupp, who finished with a 4-for-44 line on six targets and a 20-yard rush.

Cam Akers, who returned to action in Week 9 after two games as a healthy scratch, also had his best game of the season that day in the form of a 12-for-61 line on the ground against an Arizona defense that’s most recently surrendered 138.7 rushing yards per game in the last three contests.

Darrell Henderson played a minimal role in that first game but has been featured much more prominently of late, and McVay will now have the luxury of deploying both backs against what could once again be a favorable matchup.

The Cardinals have struggled to protect Kyler Murray as well with a makeshift offensive line, allowing him to be brought down on 25 occasions. That figure includes a pair of takedowns in the first meeting between the teams.

The Rams haven’t been quite as effective getting to the QB as last season with 20 sacks through eight games, but Aaron Donald and company certainly appear to have a winnable matchup on their hands.

Marquise Brown, who tormented the Rams to the tune of a 14-for-140 line in the first game, remains on IR with a foot injury, so Jalen Ramsey should be able to shadow the less speedy DeAndre Hopkins for a good portion of the afternoon. That should lead to a recipe for success for a lower-scoring Rams victory.

Cardinals vs Rams Bet Tips

Here are some Cardinals vs Rams betting trends to consider before placing your bets:

  • The Cardinals are 4-5 ATS overall, including 2-2 on the road and 0-3 in NFC West games.
  • The Rams are 2-5-1 against the spread, including 1-4 as a home team and 1-2 in division games.
  • The Over is 4-4-1 in Arizona’s games and 2-6 in Los Angeles’ contests this season.
  • The Cardinals are 11-16 straight up and 12-14-1 against the spread after a loss since Kliff Kingsbury became head coach in 2019. Meanwhile, the Rams are 20-10 straight up/17-11-2 ATS after a loss since McVay’s arrival in 2017.

Cardinals vs Rams Best Bets

Over 41.5 Total Points (-151)

As previously noted, each team’s offense still has plenty of talent despite current struggles and knows the opposing defense very well.

While this shouldn’t be an offensive extravaganza by any stretch, I see it at least being able to vault this alternate total which teases the standard figure down by a couple of points without a massive hit to the price.

Before placing this bet, get the best Cardinals promo codes.

Rams Moneyline & Over 43.5 Total Points (+203)

With my belief that the Rams pull out a win on their home field and just enough points for the Over to hit, I like this same-game parlay at an excellent price as a way to combine both predictions.

L.A.’s standard moneyline price of -170 is a stark contrast to this plus figure in particular.

Before placing this bet, get the best Rams promo codes.

Cardinals vs Rams Props

Check out the best Cardinals vs Rams player prop bets this week with our props comparison tool. Click on “Show More Games" below to find the Arizona vs Los Angeles game and see all of its prop bets.


Juan Carlos Blanco

Juan Carlos Blanco has been playing fantasy sports since 1997 and actively writing about the fantasy sports and sports betting industries since 2015 for multiple websites. He has covered a wide variety of professional sports leagues, including the NFL, MLB, NBA, CFL, Arena Football League, Alliance of American Football, XFL, NPB and KBO. He was the recipient of the FSWA's 2016 Newcomer of the Year award for his work with RotoWire.

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