Rams vs Cardinals Predictions & Best Bets

Last Updated: Nov 22, 2023

It’ll be a divisional showdown this Sunday in Arizona when the Rams visit the Cardinals. Kyler Murray is back for the Cardinals, and they no longer have the worst record in the NFL.

The Rams are coming off of an impressive win against divisional rivals Seattle and are back in the race for a wildcard spot this season.

Let’s dive into the odds and best bets for this NFC West matchup. If you’re still alive in your survivor pools, see how these two teams stack up in the Week 12 Survivor Rankings.

Rams vs Cardinals Odds

NFL odds used for this Los Angeles vs Arizona preview were found at Caesars Sportsbook and are current as of Wednesday, Nov. 22, at 10 a.m.ET.

  • Moneyline: Cardinals (-110) • Rams (-110)
  • Spread: Pickem (-110) • Pickem (-110)
  • Total Points: Over 44.5 (-110) • Under 44.5 (-110)
  • Implied Score: Cardinals 22.25, Rams 22.25

Rams vs Cardinals Predictions

Score Pick: Rams 20, Cardinals 17

One of the biggest question marks going into this contest is the health of Rams WR Cooper Kupp. His current status is day-to-day, so we do not know if he will be available for the Rams offense in this contest.

Kupp is one of the best WRs in the NFL and the top offensive option for the Rams. I still think the Rams are a better team defensively, which is why I still think they will pull out this road victory.

L.A. will be getting RB Kyren Williams, who torched the Cardinals on the ground for 158 yards earlier in the season, back this week.

The return of Murray and James Conner gives the Cardinals offense a big boost, but they still lack a legitimate passing-game offense, and that will hurt them in this matchup. The Rams only allow 217.8 yards passing per game on the year, which is 13th best in the league.

Rams vs Cardinals Best Bets & Props

Under 44.5 (-110)

Caesars Sportsbook • WAGER: 1 Unit

The Under is 7-3 in the Rams games this season, and the two teams only scored a combined 35 points in their previous matchup. The Cardinals also play at one of the slower paces in the NFL, averaging only 60.7 plays per game.

Both offenses are also middle of the pack in the league in rushing attempts per game, so I expect the clock to keep running in this contest. The Under in this game is my favorite NFL bet of the day.

Rams (-110)

Caesars Sportsbook • WAGER: 1 Unit

Divisional games in the NFL are always tough and more times than not, the team with the better defense comes out on top. The Rams defense has impressed this season, especially in games against other NFC West teams.

The Rams restricted the Cardinals to only nine points in their first matchup in the year, and the Seahawks only scored 29 points in their two games combined against them. The 49ers were the only divisional team to have success against L.A., scoring 30 points.

Kyren Williams Anytime TD (+100)

Caesars Sportsbook • WAGER: 1 Unit

Williams returns to the Rams offense this week and will likely be a big part of the offense. With the uncertainty with Kupps availability, I expect Sean McVay to pound the rock with Williams.

He had 20 carries in their first matchup earlier in the season, and the Cardinals have struggled against the run, allowing 132.1 yards per game on the ground.

Rams vs Cardinals Same Game Parlay

Rams vs Cardinals SGP (+575)

Caesars Sportsbook • WAGER: 0.25 Units

  • Alternate Under 50.5 (-234)
  • Kyren Williams Anytime TD (+100)
  • Matt Prater Over 1.5 Field Goals Made (-104)

I like the Under in this matchup, so taking an alternate total points Under gives us some buffer space between the 44.5 line total for the game.

Williams is the most favored player to score in this contest and at +100, his leg gives us a lot of added juice in the parlay.

The Rams give up the third-most field goals per game this year at 2.3, and Matt Prater has only missed three field goals all year.


Ani Sridhar

Ani Sridhar is an NBA and soccer betting analyst at The Gameday as well as a producer at SiriusXM Fantasy Sports Radio. Residing in NY, but originally from Washington D.C and a University of Maryland alum, Ani is a long-time (and occasionally suffering) fan of all the Washington sports teams. He loves TV and movies, so just holler if you ever need someone to join your bar trivia team.

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