Colts-Titans Betting Guide for Week 10

Last Updated: Jan 9, 2021

Indianapolis Colts (5-3) at Tennessee Titans (6-2)

The Indianapolis Colts visit the Tennessee Titans at Nissan Stadium on Thursday at 8:20 p.m. ET. Here’s our Colts-Titans Betting Guide.

All odds and lines from PointsBet, current as of Tuesday at 9 p.m. ET.

Colts-Titans Betting Guide

Colts-Titans Odds and Betting Lines

  • Against The Spread: Titans -2 (-110) / Colts +2 (-110)
  • Moneyline: Titans (-131) / Colts (+110)
  • Total: 48.5 — Over 48.5 (-110) / Under 48.5 (-110)
  • Implied Team Totals: Titans 25, Colts 23

Titans host Colts in Thursday night battle for first place in AFC South.

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Colts-Titans Injury Report


  • TE Jack Doyle (concussion), Doubtful
  • TE Mo Alie-Cox (knee), Questionable
  • WR Parris Campbell (knee), IR, Expected return Week 10


  • WR Adam Humphries (concussion), Questionable
  • CB Chris Milton (hamstring), Questionable

Colts-Titans Players to Watch

IND QB Philip Rivers struggled against the Ravens last week, going 25-for-43 for 227 yards and an interception. His previous two performances were much better, tallying three passing TDs in each contest. Facing a Titans secondary that has allowed at least two passing TDs in seven straight games, I’m expecting a bounce-back game from the veteran QB.

It’s his lead back that’s been a bit of an enigma this season. Rookie RB Jonathan Taylor has just 49 rushing yards on 17 carries since the Colts’ Week 7 bye. He lost a fumble for the first time in more than 100 carries last week, but also scored another TD. The Titans D has allowed at least one rushing TD in six of its eight games, something that could keep Taylor both fantasy and touchdown-prop relevant. Also of note, Jordan Wilkins led the Colts in carries last week with 11, most of which came following Taylor’s costly fumble.

Colts-Titans Betting Guide: Derrick Henry could have trouble against the Colts defense on Thursday night
Tennessee Titans running back Derrick Henry runs the ball against the Steelers in Week 7. Mandatory Credit: Steve Roberts-USA TODAY Sports

Speaking of running backs, TEN RB Derrick Henry is coming off his first game in six contests without a rushing TD. The back racked up all eight of his TDs in those previous five games. However, I can’t expect a big game from the star RB. The Colts D hasn’t allowed a 100-yard rusher this season and against the Ravens’ rushing attack last week, this unit allowed less than 2.5 yards per carry to Baltimore’s stable of running backs.

This says to me that it’s going to be a Ryan Tannehill game. The QB has thrown for almost 2,000 yards, 19 TDs and just three picks in eight games this season. He’s tallied 15 of those 19 touchdowns in the Titans’ six wins and has also thrown six touchdowns to WR A.J. Brown over the team’s last five games overall.

Despite facing a quality Colts’ secondary on Thursday, that group has allowed 300-yard passers in two of its last three games and gave up 58 yards and a TD on the ground to Lamar Jackson in Week 9. Tannehill could be affective with his legs also, as he’s averaging 4.8 yards per carry on 22 rushes to go along with a single rushing score this season.

Colts-Titans Weather Report

The weather report for Nissan Stadium calls for a partly cloudy night with a low temperature of 43 degrees Fahrenheit. Wind gusts of up to 7 mph and a 4% chance of precipitation is also expected.

Colts-Titans Betting Guide

BEST BET: Over 48.5 (-110)

While the Titans have hit the over five times in eight games, the Colts have split, going 4-4. If we take what these two teams are averaging in points per game, we get 55 points (Colts 26.0, Titans 29.0). Plus, the Titans have scored exactly 44 points in each of their last two games, and since I’m leaning to the Titans to win, that pushes me to take the over on Thursday night.

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CONSIDER: Titans (-131)

This is a really cheap number for a home favorite on a short week. Even though this is an AFC South matchup where the two teams clearly know one another, the Titans are the better squad here. Tennessee is 3-1 straight up as a home favorite this season while the Colts lost their only 2020 game as a road dog. I guess I could take the Titans -2 (-110), but we’ve seen stranger things happen in these divisional games on Thursday night. I’ll play it “safe" while considering a play on the Titans moneyline.

PASS: Colts +2 (-110)

If you’re taking the Colts, please take them moneyline as the additional two points should not make a difference on Thursday night. They’ll either win outright or lose by 3 or more.

Pauly Parlays is 27-15-2 on his NFL Best Bets in 2020.

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