NFL Week 12 Best Bets: 3 Spread Picks for Sunday’s Slate

Last Updated: Nov 20, 2025

With Thanksgiving just around the corner, NFL playoff races are heating up.

Contending teams are jockeying for positioning, while some pretenders have already turned their attention to the offseason.

Ahead of Sunday, let’s tackle my favorite NFL Week 12 predictions.

NFL Week 12 Best Bets

All NFL odds used for these Week 12 best bets are current as of Thursday, Nov. 20, and courtesy of DraftKings Sportsbook.

Chicago Bears -2.5 (-115) vs. Pittsburgh Steelers

Ben Johnson looks like he was the right head-coaching hire for the Bears, who sit atop the NFC North at 7-3 after three straight wins. While they’ve been far from dominant the last two weeks, squeaking by the Giants and Vikings, their ability to pull out close, hard-fought games cannot go unnoticed.

Aaron Rodgers is pushing to play despite a fractured wrist. While he’s historically owned the Bears, it’s fair to wonder if he’ll be compromised.

That alone makes me hesitant to back the Steelers.

Lay the points with the Bears using our best sportsbook promos for 2025.

Kansas City Chiefs -3.5 (-105) vs. Indianapolis Colts

Can the Chiefs possibly fall below .500? The AFC West is probably out of reach. Soon, so too will the playoffs if Kansas City is unable to turn it around.

The Colts are 8-2 and statistically have the NFL’s best offense, but they’ve been slightly less productive on the road (29.8 PPG) compared to at home (33.7 PPG).

While Indianapolis should be refreshed coming off its bye, I’m backing a desperate Chiefs team at Arrowhead for my Week 12 NFL picks.

Dallas Cowboys +3 (+100) vs. Philadelphia Eagles

The Eagles’ defense is humming after holding the Packers and Lions to single digits in back-to-back weeks. But Dak Prescott has always played well against Philadelphia, especially at AT&T Stadium, where he is 6-1 with 14 touchdown passes and a passer rating of 97.4.

Jalen Hurts and Co. may be able to exploit Dallas’ 31st-ranked scoring defense, but the Cowboys have the firepower to match.

The Cowboys are 3-1 ATS and 1-2-1 outright as an underdog this season. Look for them to keep it close, if not win outright, as one of my best NFL bets today.

Author

Doug Bonjour

Doug covered college and prep sports in Connecticut for more than a decade, including stints as the UConn women’s basketball and UConn football beat reporter for Hearst Connecticut Media. During his time reporting on the 11-time national champion Huskies, he covered three NCAA Final Fours. He also has written for the Associated Press and New York Times.

Related articles

Promotions

Bet $5, Get $200 in Bonus Bets

5 stars

Bet $5 & Get $150 in Bonus Bets

5 stars

Bet $5, Get $200 in Bonus Bets

5 stars

Bet $1, Double Your Winnings on Next 20 Bets

5 stars

Bet and get up to $2,000 in No Sweat Bets FanCash

5 stars

Bet $5 Get $300 in Bonus Bets

5 stars

Get A Bonus Bet Up To $250

5 stars

If you or someone you know has a gambling problem and wants help, please call 1-800-GAMBLER.

21+ and present in OH. Gambling Problem? Call or text 1-800-GAMBLER (CO, DC, IL, IN, LA, MD, MS, NJ, OH, PA, TN, VA, WV, WY).

Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-270-7117 for confidential help (MI).

GAMBLING PROBLEM? CALL 1-800-GAMBLER, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY).

Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD).

21+ and present in most states. (18+ DC/KY/NH/WY). Eligibility restrictions apply.

All betting content on TheGameDay.com is exclusively intended for audience members 21 years and older who are permitted to gamble in legal states. The Game Day may earn revenue from site visitor referrals to betting services.

Responsible Gaming: Many sportsbooks offer ways to encourage responsible gaming, including the establishment of limits to deposits, spending, and time dedicated to betting.

The Game Day is a TGD Marketing Ltd. endeavor.