NFL Week 11 Best Bets: 3 Spread Picks for Sunday’s Slate

Last Updated: Nov 12, 2025

Week 11 of the NFL season is here, and unlike the last few weeks, only two teams are on bye: The Indianapolis Colts and the New Orleans Saints.

Additionally, the New York Giants head into the week without starting quarterback Jaxson Dart, who suffered a concussion on Sunday, and head coach Brian Daboll, who was fired following a 24-20 loss in Chicago.

In addition to a pick for the Giants’ game, check out my other NFL Week 11 predictions below.

NFL Week 11 Best Bets

All NFL odds used for these best bets are current as of Wednesday, Nov. 12, and courtesy of DraftKings Sportsbook.

New York Giants +7 (-105) vs. Green Bay Packers

Leading off my Week 11 NFL picks are the Giants.

With Daboll gone and Dart hurt, New York will turn to third-string quarterback Jameis Winston and offensive coordinator Mike Kafka, who will serve as the team’s interim head coach.

While Winston is undoubtedly one of the most volatile quarterbacks we’ve seen in recent memory, his gunslinger mentality certainly helps when thinking about this Giants offense.

As for the Packers, they put up just seven points on Monday Night Football. Yes, that performance came against a good Eagles defense, and the Giants have one of the worst in the league, especially against the run.

That said, if the Packers push to run the ball more, that could actually help the Giants stay within the number. Look for Winston to throw plenty and keep the Giants within seven, but the Packers win outright.

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Houston Texans -7 (-115) @ Tennessee Titans

To me, it doesn’t matter if it’s C.J. Stroud or Davis Mills under center for the Texans in Week 11.

Either way, this Titans offense needs to contend with the Texans’ defense, and that’s simply not going to end well. These teams played earlier this season in Houston, and the Titans couldn’t muster a single point.

While I expect Tennessee to do a bit better at home, its offense will continue to stall out against a Houston defense that allows just 90.3 rushing yards (second-fewest) and 171 passing yards (fourth-fewest) per game.

Remember: Through nine games, the Titans are 1-8, and rookie quarterback Cam Ward has just five passing touchdowns and six interceptions.

I’m backing the Texans to win by a touchdown as one of my best bets for NFL Week 11.

Baltimore Ravens -7.5 (-115) @ Cleveland Browns

While the Browns were known for having a stiff run defense—and they still do if you look at the season-long numbers—they’ve been noticeably worse against it lately, allowing 134.3 rushing yards per game over their last three. That’s 11th-worst in the NFL.

Now, they have to take on a Ravens team that has Lamar Jackson back at full health and will need to handle running back Derrick Henry.

The Browns have had Henry’s number lately, but I’m more concerned about this Browns offense. If the Ravens put up 21 points, they could still cover in this game.

Cleveland put up 20 against the New York Jets, but managed just 13 against the New England Patriots in its last two outings.

The Ravens certainly have a beatable pass defense, but I don’t trust Browns rookie quarterback Dillon Gabriel enough to take advantage.

Author

Richard Janvrin

Before and after graduating from the University of New Hampshire with a degree in journalism, Richard spent time writing for Bleacher Report covering the NFL, MLB, and multiple other sports. Richard has written in the online casino/sportsbook space for nearly 3 years since his time at Bleacher Report. In his free time, Richard enjoys spending time with his son, creating content on his YouTube channel, and writing music.

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