In Week 10 of the 2025-26 NFL season, there are 14 games on the schedule, including Thursday Night Football, Sunday Night Football, Monday Night Football, and the international game live from Berlin, Germany, between the Indianapolis Colts and the Atlanta Falcons.
As for the teams on a bye, we won’t be seeing the Tennessee Titans, Cincinnati Bengals, Dallas Cowboys, or Kansas City Chiefs.
Below, I’ll cast my NFL Week 10 predictions for the Sunday slate of games.
NFL Week 10 Best Bets
All NFL odds used for these best bets are current as of Thursday, Nov. 6, and courtesy of DraftKings Sportsbook.
Carolina Panthers -5.5 (-110) vs. New Orleans Saints
Leading off my Week 10 NFL picks, I’m backing the Panthers.
Heading into this game, Saints rookie quarterback Tyler Shough is making his second career start, and it comes on the road against the Panthers, who are 3-1 against the spread when playing in Charlotte. This team isn’t usually favored by this much, but this time, it makes sense.
Shough certainly didn’t have it easy in his first NFL start last week, taking on the Los Angeles Rams, but in that game, he completed just 62.5% of his passes for 176 yards, one touchdown, and one interception. Across 54 career attempts, including in relief of Spencer Rattler in Week 8, he’s averaging just 5.4 yards per attempt.
Now, he’ll be without a deep threat in Rashid Shaheed, who was traded to the Seattle Seahawks, and the Panthers have allowed fewer than 190 passing yards per game over their last three.
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Jacksonville Jaguars -1.5 (-108) @ Houston Texans
After suffering a concussion in Week 9, the Texans will be without quarterback C.J. Stroud and will turn to Davis Mills in this home game against the Jaguars.
While Mills has been around for a while, I don’t expect him to necessarily throw multiple interceptions and make life difficult for his team. I do question exactly what this offense can do with him at the helm.
In relief of Stroud last week, albeit against a stout Denver Broncos defense, Mills completed just 56.7% of his passes for 137 yards and averaged 4.6 yards per attempt.
As for the Jaguars, they may not have the best pass defense in the world, allowing 249.3 per game (sixth-most), but they added wide receiver Jakobi Meyers at the trade deadline to add more juice to this offense.
I’m not expecting much from the Texans in this one.
Baltimore Ravens -4.5 (-102) @ Minnesota Vikings
To close out my best bets for NFL Week 10, I’m taking the Ravens -4.5 on the road.
While I respect Vikings defensive coordinator Brian Flores, his style may bode well for the Ravens offense and quarterback Lamar Jackson.
This season, the Vikings have sent the blitz on 110 opposing quarterback dropbacks, which is the third-highest rate in the league.
When blitzed, Jackson has been phenomenal, completing nearly 79% of his passes with seven touchdowns and just one interception.
Furthermore, the Vikings are allowing opposing running backs to run 25.38 times (third-most) for 102.88 yards (10th-most), and 0.62 touchdowns per game.
Look for running back Derrick Henry to move the ball effectively and for Jackson to capitalize on the blitz if the Vikings send it.
