NFL DFS Best Picks Week 4 – PrizePicks Lineups & Sleepers

This year’s NFL injury plague has already continued in Week 4, as the Jacksonville Jaguars lost DJ Chark indefinitely with a left ankle fracture during Thursday Night Football against the Cincinnati Bengals.

If you’d like to limit the negative affect that injuries may have on your fantasy football fun, playing Daily Fantasy Sports may be a good route for you. DFS or sports betting is also an easy way to inject some excitement into the less riveting matchups on the NFL slate.

If you’re looking for a way to combine the fun of betting and fantasy, PrizePicks may be the perfect site for you. Unlike the typical salary cap lineup construction format that most DFS sites follow, PrizePicks has users build their own parlays by selecting Over or Under on up to five specific player props instead. The more props you select, the higher the multiplier on the entry fee.

Another plus about PrizePicks is their Flex Play option, which allows users to win even with missed picks, though it lowers the potential payout for perfect picks. Now that you understand how PrizePicks works, let’s get into the DFS football predictions series for Week 4!

Stat information for NFL DFS Week 4 picks are current as of Friday, October 1, at 12 PM ET.

NFL Week 4 Best Player Prop Bets

Check out the best player prop bets this week with our props comparison tool, including projections to help you make the best decisions. Click “Place Bet” to unlock the associated sportsbook’s welcome offer and place your bet. Select the game you want to highlight, including this week’s highly anticipated Buccaneers vs Patriots matchup.

Learn more about NFL prop bets and the best sportsbooks for prop betting.

NFL DFS Week 4: Single-Stat Daily Fantasy Sports

With the single-stat game format, users will pick Over or Under for a player’s performance in a single stat. Users can string picks together across different games and sports.

Lamar Jackson, QB, Baltimore Ravens

Over 0.5 Interceptions

Lamar Jackson has thrown three picks over his last two games and now faces a scary Denver Broncos defense that ranks fourth in interception percentage (3.81%). We’ve also seen the Baltimore Ravens’ offensive line get bullied in pass protection multiple times this season. Von Miller will be their toughest opponent to date, and he will likely have an influence on Jackson and this game.

Mike Gesicki, TE, Miami Dolphins

Over 32.5 Receiving Yards

The quarterback switch from Tua Tagovailoa (IR) to Jacoby Brissett has helped Mike Gesicki more than any other Miami Dolphin pass-catcher. Gesicki’s performance has improved dramatically since Brissett took over in Week 2, hauling in 13 of 18 targets for 127 receiving yards after being held catch-less in Week 1. Facing an Indianapolis Colts team that will bring the pressure on Sunday, expect Gesicki to get plenty of attention underneath from his quarterback yet again.

Hunter Renfrow, WR, Las Vegas Raiders

Over 46.5 Receiving Yards

Hunter Renfrow is off to a hot start in the Las Vegas Raiders’ high-flying offense, cementing himself as Derek Carr‘s security blanket. Renfrow has tallied at least five catches and 50 receiving yards in all three games, emerging as a reliable option in the Raiders’ passing attack. Look for Renfrow to be busy again in a potential Week 4 shootout with Justin Herbert‘s Los Angeles Chargers.

Hunter Renfrow Las Vegas Raiders WR

Las Vegas Raiders WR Hunter Renfrow has established himself as one of Derek Carr’s most reliable targets this year. (Image: USA TODAY Sports)

Sportsbook Play of the Day

Before checking out the rest of our fantasy football picks of the day, consider signing up at PrizePicks! PrizePicks is a user-friendly platform that features a wide array of games, easy-to-understand contest formats, and an excellent first deposit match of up to $100 when you use our code GAMEDAY to sign up.

Read Juan Carlos Blanco’s PrizePicks review for more insight and fantasy football tips get your welcome bonus below, or continue reading our fantasy football tipster picks.



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NFL DFS Week 4: Fantasy Score Game

The Fantasy Score Game format follows the same concept as the Single-Stat Game. However, instead of picking a player’s performance in a stat category, users will pick Over or Under a player’s fantasy point total. For NFL DFS, PrizePicks follows a PPR scoring format.

Cordarrelle Patterson, RB, Atlanta Falcons

Over 10.5 Fantasy Points

Cordarrelle Patterson continues to be fantasy football sleeper. He’s been heavily featured in the Atlanta Falcons’ offense this season, recording seven carries in all three games while also racking up 13 catches on 16 targets. The receptions alone will get him halfway to this point total, then the yardage or a touchdown should take him over.

Kirk Cousins, QB, Minnesota Vikings

Over 20.5 Fantasy Points

Kirk Cousins is another DFS sleeper, as he’s sneakily eclipsed 25 fantasy points in every game this season. This week, he’ll face a Browns team at home that’s surrendering over 20 fantasy points to quarterbacks this season, even after Justin Fields did literally nothing against them last week. Given the weapons at his disposal, picking Cousins over 20.5 points is an easy one.

Damien Harris, RB, New England Patriots

Under 9.5 Fantasy Points

This is the worst possible matchup for Damien Harris, who will face the Tampa Bay Buccaneers’ stingy run defense on Sunday Night Football. Despite losing James White (hip) to the IR last week, the Patriots still didn’t use Harris in the receiving game much. With just five receptions on six targets for 16 receiving yards thus far, his fantasy success will need to come on the ground.

That will be hard to come by against the Buccaneers, who have allowed the NFL’s third-fewest yards per rush (3.1). Their stout run defense means Harris will likely need a touchdown to go over this fantasy point total, which is tough to bank in on a game where Mac Jones will need to air it out to keep pace with Tom Brady.

Thanks for reading our NFL Week 4 Best DFS Picks! For more NFL betting tips, check out our NFL Week 4 Best Prop Bets.

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Schedule & Odds

Top Offers

NBA Betting News

  • Celtics +300 to win NBA Title

    The Boston Celtics are +300 to win the 2021-22 NBA Championship, per BettingPros consensus odds.

    Betting Impact:
    The Celtics are +300 ahead of their home date with the Warriors for Game 6. We will see a considerable odds shift if the Celtics can win Game 6 on their homecourt. Boston was +310 after Game 5.

  • Celtics vs. Warriors over/under listed at 210

    The over/under for Game 6 of the NBA Finals between the Boston Celtics and the Golden State Warriors is listed at 210, per BettingPros consensus odds.

    Betting Impact:
    The total for this contest sits at 210, down from the 210.5 it opened at. 60 percent of the public action has come on the over.

  • Warriors -400 to win NBA Championship

    The Golden State Warriors are -400 to win the NBA Championship, per BettingPros consensus odds.

    Betting Impact:
    Golden State now sits at a prohibitive -400 to win the NBA Championship. For comparison, Stephen Curry MVP is -360. Andrew Wiggins, the dark horse to steal the award with a big close-out game, sits at +2000.

  • Celtics +310 to win NBA Championship

    The Boston Celtics are +310 to win the 2021-22 NBA Championship, per BettingPros consensus odds.

    Betting Impact:
    The Celtics peaked as high as high as -230 prior to Game 3 and now sit at an attractive +310. Boston entered the season at +4000. The odds could swing wildly again if Boston wins Game 6.

  • Warriors vs. Celtics over/under listed at 210.5

    The over/under for Game 5 of the NBA Finals between the Golden State Warriors and the Boston Celtics is listed at 210.5, per BettingPros consensus odds.

    Betting Impact:
    The total for this contest sits at 210.5, down from the 212.5 it opened at. 72 percent of the public action has come on the over.