NFL Week 2 Odds | Opening NFL Moneyline, Spread, & Total Betting Lines

Last Updated: Jan 23, 2023

Week 1 of the 2022 NFL season provided plenty of drama, a handful of upsets, and a lot of missed kicks.

Now, it’s time to figure out which of those Week 1 results really meant something as we head into Week 2, which tends to be the biggest overreaction week of the year.

Here are the current Week 2 NFL odds and lines for the 2022 season.

NFL Week 2 Odds & Lines

Week 2 NFL odds are courtesy of FanDuel Sportsbook unless otherwise noted and are current as of Monday, Sept. 12 at 1 p.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 2.

NFL Week 2 Games

Los Angeles Chargers @ Kansas City Chiefs (Thursday Night Football)

Chargers +3.5 (-114) @ Chiefs -3.5 (-106)

The new era of Thursday Night Football on Amazon Prime Video kicks off with one of the games of the season as Justin Herbert and the Chargers visit Patrick Mahomes and the Chiefs. Los Angeles has won its last two visits to Arrowhead but may have to take this trip without wideout Keenan Allen (hamstring) and corner J.C. Jackson (ankle).

Kansas City looked just fine without Tyreek Hill in a season-opening win over the Cardinals as Mahomes threw for 360 yards and five touchdowns. Don’t expect that kind of offensive output against an improved Chargers defense, but the Chiefs should still get the win.

Washington Commanders @ Detroit Lions (Sept. 18, 1 p.m. ET)

Commanders +1.5 (-108) @ Lions -1.5 (-112)

The Lions don’t quit under Head Coach Dan Campbell, but they don’t tend to win a lot of games either.

After losing their home opener against the Eagles, 38-35, Detroit will look to bounce back against a Commanders team that defeated the Jaguars in Carson Wentz‘s team debut. This line is a little fishy to me, so I’ll probably stay away.

Tampa Bay Buccaneers @ New Orleans Saints

Buccaneers -2.5 (-120) @ Saints +2.5 (-102)

The Saints have been Tom Brady‘s bugaboo since joining the Buccaneers, as New Orleans has won all four games the teams have played over the past two years. Tampa Bay’s offense didn’t look particularly great in Week 1, scoring just one touchdown in a 19-3 win over Dallas.

I’m typically looking to back Jameis Winston as an underdog, but it’s hard to do so after the Saints needed to make a 16-point, fourth-quarter comeback against the lowly Falcons. Before it gets to -3, back the Bucs on the road.

Carolina Panthers @ New York Giants

Panthers +2.5 (-112) @ Giants -2.5 (-108)

These teams were on the opposite ends of close calls in Week 1.

The Giants stunned the Titans with their 21-20 win in Tennessee off the back of a late two-point conversion from Saquon Barkley, who also amassed 194 total yards and a touchdown in one of Sunday’s standout performances. Meanwhile, Baker Mayfield lost his revenge game against the Browns, as Cade York nailed a 58-yard field goal to give Cleveland a 26-24 victory.

Can the new-look Giants be trusted to back up that win at home? This could go either way.

New York Jets @ Cleveland Browns

Jets +6.5 (-110) @ Browns -6.5 (-110)

I know the Jets are bad, but this feels like a lot of points for Cleveland to be laying here.

New York’s defense looked improved against the Ravens, outside of a few long balls over the top, which shouldn’t be an issue against Jacoby Brissett. The Browns’ front seven will certainly give the Jets’ o-line fits, but I don’t think this team is blowing anyone out without Deshaun Watson.

New England Patriots @ Pittsburgh Steelers

Patriots -1 (-114) @ Steelers +1 (-106)

The Patriots’ offense managed just seven points in a season-opening loss to the Dolphins, and now they’ll have to face a Pittsburgh defense that forced Joe Burrow into five turnovers in Week 1. The Steelers still nearly lost that game multiple times, which probably means you should back New England.

Indianapolis Colts @ Jacksonville Jaguars

Colts -4.5 (-110) @ Jaguars +4.5 (-110)

The last time the Colts went to Jacksonville, it was Week 18 and Indianapolis needed a win over the then 2-14 Jaguars to reach the playoffs. You know what happened next. (Hint: They lost.)

Indy, which tied its season opener in Houston, hasn’t won in Jacksonville since 2014. Even with that being said, it’s still tough to back the Jaguars after they converted just twice on five trips to the red zone against Washington in Week 1.

Miami Dolphins @ Baltimore Ravens

Dolphins +3.5 (-110) @ Ravens -3.5 (-110)

One of the marquee games of the week sees the Ravens host the Dolphins in a matchup of two teams fresh off big Week 1 wins against AFC East opposition. Lamar Jackson tossed three touchdowns in a win over the Jets, while Tua Tagovailoa threw for 270 yards and a score against the Patriots.

I’m not sure I want to back Miami in this spot, but the Ravens already have another injury crisis to be concerned about. Waiting until later in the week for more information may be the prudent play.

Atlanta Falcons @ Los Angeles Rams (Sept. 18, 4:05 p.m. ET)

Falcons +10.5 (-115) @ Rams -10.5 (-105)

The biggest spread of the week sees the Falcons as sizable road dogs against the defending champion Rams, who got their doors blown off in the NFL Kickoff game against the Bills. The Falcons were impressive in Week 1, nearly knocking off the Saints.

On the theme of not overreacting too much, I like the Rams to win big here but would wait until this spread gets to 10 (which I think it will) to buy in.

Seattle Seahawks @ San Francisco 49ers

Seahawks +8.5 (-114) @ 49ers -8.5 (-106)

The 49ers lost the first game of the Trey Lance era to the lowly Chicago Bears at a rain-soaked Soldier Field. San Francisco is again a heavy favorite against the Seahawks, who like the Bears, were expected to be among the bottom dwellers in the NFC.

I think the 49ers bounce back here, even without running back Elijah Mitchell (knee), but covering this number won’t be so easy.

Cincinnati Bengals @ Dallas Cowboys

Bengals -6.5 (-115) @ Cowboys +6.5 (-105)

The Cowboys looked downright dreadful on offense against the Buccaneers on Sunday Night Football, even before Dak Prescott came out of the game with an injured thumb that will require surgery. Now, we’re expecting Cooper Rush to lift a team with one healthy wideout?

The Bengals were sloppy in their season-opening loss to the Steelers but still should have won the game. The offensive line will have to get it together against Micah Parsons, but Cincinnati has too much talent. This number should be higher.

Houston Texans @ Denver Broncos

Texans +10.5 (-114) @ Broncos -10.5 (-106)

After playing in Seattle on Monday Night Football, the Broncos will be on short rest when they host the 0-0-1 Texans. Houston held on for a 20-20 tie with the Colts, despite leading 20-3 heading into the fourth quarter.

There’s no denying that Denver should win this game, but this number feels a bit big.

Arizona Cardinals @ Las Vegas Raiders

Cardinals +4.5 (-110) @ Raiders -4.5 (-110)

Davante Adams (10-141-1) had a productive outing in his first game with the Raiders, but Las Vegas’ comeback attempt ultimately came up short against the Chargers. Arizona’s defense should have its hands full once again this week as they try to cover Adams, Darren Waller, and Hunter Renfrow after surrendering 360 passing yards and 5 TD tosses to Patrick Mahomes.

I think the Raiders win, but Arizona might be a teaser piece for me.

Chicago Bears @ Green Bay Packers (Sunday Night Football)

Bears +9.5 (-106) @ Packers -9.5 (-114)

Sunday Night Football features an old-time NFC North rivalry between the Chicago Bears and the Green Bay Packers. Surprisingly, the Bears enter this game 1-0, while the Packers are 0-1 after a rough offensive showing in Minnesota.

Are the Bears better than we thought because they won a slop-fest? Probably not. Are the Packers worse than we thought, especially on offense? Maybe.

This feels like a lot of points, but Aaron Rodgers owns the Bears. I’d probably still lean with Green Bay here.

Tennessee Titans @ Buffalo Bills (Monday Night Football)

Titans +7 (-105) @ Bills -7 (-115)

The first game of a Monday Night Football doubleheader will feature two of the top teams in the AFC last season. While the Titans were the No. 1 seed in the conference last year, they didn’t look particularly good in their Week 1 home loss to the Giants.

Still, Mike Vrabel is one of the best coaches in the league, and Tennessee has beaten the Bills two years running. As good as Josh Allen and co. looked last Thursday, they’re favored by a lot of points here. If this gets to 10, I’m backing the Titans and hoping Derrick Henry chews up a lot of clock.

Minnesota Vikings @ Philadelphia Eagles (Monday Night Football)

Vikings +1.5 (-110) @ Eagles -1.5 (-110)

The Eagles and Vikings both looked impressive in Week 1, picking up wins against NFC North opposition in the Lions and Packers, respectively. Minnesota’s Justin Jefferson (9-184-2) and Philadelphia’s A.J. Brown (10-155) made big impacts in the receiving game in Week 1 and should be a handful for opposing defenses all season long.

Teasing the Vikings through three and seven seems to make the most sense right now unless you have a significant lean early in the week.


John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

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