NFL Week 2 Odds

Last Updated: Sep 12, 2023

Some of the featured Week 2 matchups include a playoff rematch between the Kansas City Chiefs and Jacksonville Jaguars and an early-season AFC North showdown between the Baltimore Ravens and Cincinnati Bengals. Kansas City and Cincinnati have daunting draws as both teams try to put forgettable Week 1 performances behind them.

The New York Jets also take on the Dallas Cowboys in a game that has become an apparent mismatch because of the Aaron Rodgers injury. Here are the odds and lines for Week 2 of the 2023 NFL season.

NFL Week 2 Odds & Lines

Week 2 lines are courtesy of DraftKings Sportsbook and current as of Sept. 12 at 9 a.m. ET

Keep tabs on all of our current NFL odds leading into NFL Week 2.

NFL Week 2 Games

Minnesota Vikings @ Philadelphia Eagles

Sept. 14, 8:20 p.m. ET (TNF)

  • Vikings +7 (-110) @ Eagles -7 (-110)

This will be the home opener for the Eagles and the first road game for the Vikings. Both teams have potent offenses, and while the Philadelphia offense is better overall, Justin Jefferson is the best playmaking weapon on either side.

Minnesota should be able to trade offensive punches with Philadelphia, so I will take the Vikings to cover the +7 spread.

Green Bay Packers @ Atlanta Falcons

Sept. 17, 1 p.m. ET

  • Packers -1 (-108) Falcons+1 (-112)

Two young quarterbacks square off here, as Jordan Love and Desmond Ridder try to take their teams to 2-0 starts. Love was much more impressive in Week 1, as he tossed three TD passes in a convincing win at Chicago.

If the Falcons have to play from behind in this one, Ridder might have a forgettable outing. Lock in Green Bay at -1.

Baltimore Ravens @ Cincinnati Bengals

Sept. 17, 1 p.m. ET

  • Ravens +3.5 (-110) @ Bengals -3.5 (-110)

The Ravens, our current Super Bowl 58 best bet, are looking to start the season at 2-0 here. Lamar Jackson didn’t perform as well as expected in the opener, but Baltimore still won handily.

The visitors will be without J.K. Dobbins, who suffered a devastating Achilles injury. Joe Burrow struggled through an awful performance in a wet loss at Cleveland and should be ready to rebound.

A win would be sweet revenge for Baltimore, which lost in the playoffs at Cincinnati last season. Cincinnati has won four of the last five games between the teams, though, including the playoffs, so my pick here is the Bengals at -3.5 as Burrow gets right.

Chicago Bears @ Tampa Bay Buccaneers

Sept. 17, 1 p.m. ET

  • Bears +3 (-112) @ Buccaneers -3 (-108)

The Buccaneers will ready for Justin Fields in their home opener after traveling to Minnesota for an inspiring win in Week 1. The offensive outlook for Tampa Bay is not as bleak as anticipated after Baker Mayfield led four scoring drivees.

Fields was uneven against Green Bay, passing for 216 yards with one TD and one interception. The Chicago passing game may need more time to get untracked, so Tampa Bay is the pick at -3.

Las Vegas Raiders @ Buffalo Bills

Sept. 17, 1 p.m. ET

  • Raiders +9.5 (-108) @ Bills -9.5 (-112)

Las Vegas scored a gutsy win over Denver in Week 1, but this is obviously a much tougher assignment. Jimmy Garoppolo does keep his team in games, though, and the spread is too large, so take the Raiders at +9.5.

Seattle Seahawks @ Detroit Lions

Sept. 17, 1 p.m. ET

  • Seahawks +6 (-105) @ Lions -6 (-115)

In 2022, Seattle won a shootout at Detroit, 48-45, and will likely come out sharper after looking awful in Week 1. Jared Goff played better at home last year, as he threw 23 of his 29 TD passes at Ford Field.

The Seahawks want to avoid falling to 0-2 to start the season, so expect them to stick close even if Detroit prevails. Go with Seattle at +6, as early starts for the Northwesterners have also not been a deterrent during the Pete Carroll era (22-9 in the last 31 10 a.m. PST starts).

Los Angeles Chargers @ Tennessee Titans

Sept. 17, 1 p.m. ET

  • Chargers -3.5 (-110) @ Titans +3.5 (-110)

Los Angeles will get an easier draw here in Week 2 after the intense offensive matchup with the Miami Dolphins in the season opener. The Titans will try to control the clock with Derrick Henry as usual.

The Chargers have too much firepower for Tennessee to contend with, so go with Los Angeles as the -3.5 favorite.

Indianapolis Colts @ Houston Texans

Sept. 17, 1 p.m. ET

  • Colts -1 (-110) @ Texans +1 (-110)

The obvious drawing card is the showdown between top rookie quarterbacks C.J. Stroud and Anthony Richardson. The Texans fans will also get their first look at another first-year standout, DE Will Anderson.

Richardson did a better job of moving his team’s offense in Week 1 and did his best to hang in with a much better Jaguars team. Lock in the Colts for their first win of the season at - 1 and -115 on the moneyline.

Kansas City Chiefs @ Jacksonville Jaguars

Sept. 17, 1 p.m. ET

  • Chiefs -2.5 (-118) @ Jaguars +2.5 (-102)

The Chiefs are starting at the prospect of an 0-2 start, and the Jacksonville offense looks poised to elevate to another level this season. But getting Chris Jones back puts Kansas City in a position to hang in defensively.

This will be the most compelling game of the early matchups on Sunday. I am expecting a heroic Patrick Mahomes performance, as he is one of our top bets going by the NFL MVP odds, to save his team from another loss and will opt for Kansas City at -2.5.

New York Giants @ Arizona Cardinals

Sept. 17, 4:05 p.m. ET

  • Giants -4.5 (-110) @ Cardinals +4.5 (-110)

The Giants get a seemingly merciful matchup after taking a historic beating from the Dallas Cowboys on Sunday night. But Arizona only lost by four points at Washington, when the Cardinals were expected to be easily defeated.

The Giants should still take care of business here to get a terrible Week 1 behind them, so they are the pick at -4.5.

San Francisco 49ers @ Los Angeles Rams

Sept. 17, 4:05 p.m. ET

  • 49ers -8 (-110) @ Rams +8 (-110)

We can never assume blowouts in divisional matchups, but the 49ers looked like the best team in the league in Week 1. The Rams, however, surprised everyone outside of their locker room with an upset at Seattle.

Los Angeles will simply be overmatched as reality sets in, so go with the 49ers at -8.

New York Jets @ Dallas Cowboys

Sept. 17, 4:25 p.m. ET

  • Jets +7.5 (-110) @ Cowboys -7.5 (-110)

The spread here moved 4.5 points after the Rodgers injury, and the matchup has now totally lost its luster. Expect another dominant Dallas performance on defense against a New York team, and easily ride with the Cowboys at -7.5.

Washington Commanders @ Denver Broncos

Sept. 17, 4:25 p.m. ET

  • Commanders +3.5 (-112) @ Broncos -3.5 (-108)

This is a winnable matchup for Russell Wilson to continue on his quest to bounce back to respectability. He has Sean Payton backing him now, and the former Seattle star didn’t look terrible in Week 1, even though he did not make any splash plays either in a loss.

Washington is still shaky at QB with Sam Howell, so the Broncos are my pick to cover at -3.5. Denver needs a convincing win and will get it.

Miami Dolphins @ New England Patriots

Sept. 17, 8:20 p.m. ET (SNF)

  • Dolphins -2.5 (-110) @ Patriots +2.5 (-110)

The Patriots are in danger of falling to 0-2 after an opening-week loss to the Eagles. Miami’s high-flying offensive identity is established, yet this is a chance for a defense that underachieved last year and in Week 1 to perform up to its talent levels under Vic Fangio.

New England won its home meeting with Miami by two points last year. However, the Dolphins need to win consistently over lesser opponents to emerge as a true AFC contender, so they are the pick at -2.5 and -135 on the moneyline.

New Orleans Saints @ Carolina Panthers

Sept. 18, 7:15 p.m. ET (MNF)

  • Saints -3 (-115) @ Panthers +3 (-105)

These NFC South rivals have made changes at QB that can alter the outlooks of both franchises. Derek Carr is hoping to get the Saints back to the playoffs, while Bryce Young is the future of the Panthers’ franchise and the team’s brain trust will be patient with him.

The New Orleans defense is coming off a three-interception performance in Week 1 and will be the difference here, so I will take the Saints at -3.

Cleveland Browns @ Pittsburgh Steelers

Sept. 18, 8:15 p.m. ET (MNF)

  • Browns -2 (-110) @ Steelers +2 (-110)

The Browns scored a resounding opening week win over one major rival, and now aim for two in a row. Pittsburgh isn’t going to get blown out again, but the Browns are the better team this time and I will take them at -2.


Scott Engel

Scott Engel is a Senior Sports Writer at The Game Day. Previously he was at and The Athletic. His work is also featured at RotoBaller and on Scott is a host on SiriusXM Fantasy Sports Radio. He is an inaugural member of the Fantasy Sports Writers Association's Hall of Fame. Scott is a four-time FSWA award winner and a 13-time finalist. He was an Associate Editor and featured writer at and his career began at CBS SportsLine, where he was a Senior Writer and Managing Editor. Scott was the Managing Director at RotoExperts.

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