NFL Week 2 Odds | Opening NFL Moneyline, Spread, & Total Betting Lines

Posted: Jul 13, 2022Last updated: Aug 3, 2022

Week 1 of the 2022 NFL season is loaded with several intriguing matchups and great quarterback battles. However, Week 2 might be an even better week of football, starting with the heavyweight fight on Thursday Night Football between the Chargers and Chiefs on Amazon Prime.

Here are the current Week 2 NFL odds and lines for the 2022 season.

NFL Week 2 Odds & Lines

Week 2 NFL odds are courtesy of FanDuel Sportsbook unless otherwise noted and are current as of Wednesday, July 13 at 11 a.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 2.

NFL Week 2 Games

Los Angeles Chargers @ Kansas City Chiefs (Thursday Night Football)

Chargers +3 (-110) @ Chiefs -3 (-110)

This is one of the most highly anticipated games of the year as we get to see Justin Herbert and Patrick Mahomes battle once again. Don’t forget that the Chargers upset the Chiefs in Kansas City last year and will look to do it again in 2022.

With the Chargers getting three points in this game, it might not be a bad idea to bet on them now as that line might move before kickoff.

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Washington Commanders @ Detroit Lions (Sept. 18, 1 p.m. ET)

Commanders -1 (-110) @ Lions +1 (-110)

The Lions will be at home for the second straight week, this time hosting the Washington Commanders. The talent differential isn’t big between these two teams and we know that Jared Goff and Carson Wentz are similar quarterbacks.

For that reason alone, there is a lot of value on the Lions as a home dog in this matchup.

Tampa Bay Buccaneers @ New Orleans Saints

Buccaneers -4 (-110) @ Saints +4 (-110)

Since joining the Buccaneers, Tom Brady has lost all four of his regular-season meetings against the Saints. And last year, the Bucs failed to score a single point at home against New Orleans.

The Saints just have Brady’s number and that’s why it’s shocking to see them giving four points at home. New Orleans as a home dog against Tampa Bay is a bet worth making right now as that line might move closer to a pick’em before kickoff.

Carolina Panthers @ New York Giants

Panthers +1 (-115) @ Giants -1 (-105)

This game will feature the No. 1, No. 2, and No. 3 picks from the 2018 NFL Draft (Baker Mayfield, Saquon Barkley, Sam Darnold). That hasn’t happened in an NFL game in several decades.

But should the new-look Giants be favored over the Panthers in this Week 2 contest? It’s tough to decide, especially considering we aren’t quite sure who will be under center for the Panthers yet. It’s best to avoid this line until we see both of these teams in the preseason and Week 1.

New York Jets @ Cleveland Browns

Jets +6.5 (-110) @ Browns -6.5 (-110) at Bet365

This is another tough game to bet on early because we don’t know the status of Deshaun Watson. This line feels far too high for the Browns if Watson isn’t under center, which is likely to happen.

So if you believe Watson is going to miss this contest, consider taking the Jets at +6.5 on this Week 2 line.

New England Patriots @ Pittsburgh Steelers

Patriots -1.5 (-110) @ Steelers +1.5 (-110)

The Patriots have certainly had the Steelers’ number over the last two decades. But that was with Tom Brady under center. How will Mac Jones handle the Steelers’ pass rush in Pittsburgh?

The good news for New England is that they also have one of the NFL’s best defenses and should be able to slow down Mitchell Trubisky or Kenny Pickett. Consider taking New England -1.5 as they just have a much more complete roster entering the season.

Indianapolis Colts @ Jacksonville Jaguars

Colts -4.5 (-110) @ Jaguars +4.5 (-110)

We all remember what happened in Week 18 when the Colts needed a win to beat the Jaguars to make the playoffs. The Colts have not won in Jacksonville since 2014 and it could be another tough game for them with the early September heat.

If you are considering betting on the Colts to win this game, you might want to wait and see how this line moves before kickoff. Otherwise, the Jaguars as a 4.5-point home dog is a pretty good bet entering the season.

Miami Dolphins @ Baltimore Ravens

Dolphins +4 (-110) @ Ravens -4 (-110) 

The Dolphins put on a defensive clinic last season when facing Lamar Jackson, but that was with Brian Flores running the defense. Expect Jackson to play much better and for the Ravens to have a significantly different offensive game plan this time around.

Taking Baltimore -4 is probably the smart bet here, but this should be a fantastic game between two non-playoff teams from a year ago.

Atlanta Falcons @ Los Angeles Rams (Sept. 18, 4:05 p.m. ET)

Falcons +13 (-110) @ Rams -13 (-110)

The biggest spread of the week features the Rams as a near two-touchdown favorite and that might even be a tad low. The Falcons have one of the worst defenses in the NFL and an offense that could really struggle to score points.

While it’s always a bit scary to bet on a team at -13 a few months in advance, this one is about as safe as it gets. The Rams are just so much more talented and should run away from the Falcons here in Week 2, making this our NFL pick of the day.

Seattle Seahawks @ San Francisco 49ers

Seahawks +7.5 (-110) @ 49ers -7.5 (-110)

The Seahawks and 49ers have had some incredible games over the last decade, but this doesn’t figure to be one of them. Seattle will be coming off an emotional Monday Night Football game against Russell Wilson and the Broncos.

The 49ers are the far more talented team and should easily win this game. Don’t be afraid to take the 49ers -7.5 on the early line now.

Cincinnati Bengals @ Dallas Cowboys

Bengals +2.5 (-110) @ Cowboys -2.5 (-110)

The Cowboys are notoriously slow starters and they’ve got a ton of new pieces on both offense and defense. Meanwhile, the Bengals brought back nearly their entire roster and have the pieces on offense to exploit Dallas.

This will be a close game, but the Bengals getting 2.5 points feels wrong as it should be closer to a pick’em. Take the points here with the Bengals as they are just the better team with the better quarterback entering the season.

Houston Texans @ Denver Broncos

Texans +10.5 (-110) @ Broncos -10.5 (-110)

Coming off a Monday Night Football matchup with the Seahawks, the Broncos will host the Texans in Week 2. This is a great spot for them to start off the season 2-0 against one of the worst rosters in the NFL.

However, 10.5 points on a short week might be a little too much respect for the Broncos. Instead, wait on this line until after Week 1 as it could move down a little bit.

Arizona Cardinals @ Las Vegas Raiders

Cardinals +2 (-110) @ Raiders -2 (-110)

The Cardinals are usually a team that starts off the season hot, but this is a tough matchup for them as the Raiders are loaded with talent all over the field.

There is also a revenge factor here for both Chandler Jones and Kenyan Drake, who left the Cardinals in free agency. Take the Raiders -2 here as they are better in all three phases than the Cardinals.

Chicago Bears @ Green Bay Packers (Sunday Night Football)

Bears +8.5 (-110) @ Packers -8.5 (-110)

The showcase game on Sunday Night Football features the Chicago Bears and the Green Bay Packers. And frankly, this likely won’t be a very entertaining contest.

The Packers have one of the best defenses in the NFL and a back-to-back MVP at quarterback in Aaron Rodgers. Meanwhile, the Bears gutted their defense and failed to add any help on the offensive line for Justin Fields. 

Grab this line at Packers -8.5 now before it balloons up to 10.5 before kickoff.

Tennessee Titans @ Buffalo Bills (Monday Night Football)

Titans +7 (-105) @ Bills -7 (-115)

The first of two Monday Night Football games will feature two of the best teams from the AFC last season in the Titans and Bills. While Buffalo has a much better overall roster, it might be wise to exercise some caution here.

Mike Vrabel is one of the best coaches in the NFL and his team has now beaten the Bills in back-to-back seasons. The Titans are a tough team to play against and that seven-point spread feels a bit disrespectful.

Minnesota Vikings @ Philadelphia Eagles (Monday Night Football)

Vikings +2 (-110) @ Eagles -2 (-110)

The second Monday Night Football game of Week 2 will feature the Vikings and Eagles. Both offenses have made a lot of changes over the offseason and will get a chance to shine in primetime.

The smart bet here is to take the Eagles as a 2-point favorite, but this might be a bet worth waiting on until kickoff.


Marcus Mosher

Marcus Mosher is an NFL analyst at The Game Day, residing in Erie, PA. He covers the NFL from a betting and fantasy perspective, producing written and video content. Marcus currently hosts multiple football-related podcasts and is a managing editor at USA Today’s Sports Media Group covering the Las Vegas Raiders. He has previously worked at The Athletic and Bleacher Report.

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