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Seahawks vs 49ers Predictions | Best Bets & Odds

Posted: Sep 16, 2022Last updated: Sep 16, 2022

The surprising Seattle Seahawks will try to start 2-0 when they trek south to take on the NFC West-rival San Francisco 49ers at Levi’s Stadium in Santa Clara, California on Sunday.

Seattle put forth a defensive masterpiece and stunned the Denver Broncos 17-16 in each team’s season opener on Monday night. Geno Smith was efficient, completing 23-of-28 passes for 195 yards and two touchdowns, and the Seahawks forced two turnovers — both fumbles near the goal line.

The 49ers, a trendy dark-horse pick to win both the NFC and Super Bowl, are 0-1 after their shocking 19-10 loss to the Bears at Soldier Field on Sunday. Trey Lance struggled in his first game as San Francisco’s full-time starter, completing just 13-of-28 passes for a paltry 164 yards.

Here’s a look our favorite Seattle vs San Francisco betting tips for Week 2.

Seahawks vs 49ers Odds

Oddsmakers aren’t quite ready to cast off the Niners after one off week, nor are they feeling compelled to elevate the Seahawks after their surprising victory against the Broncos. San Francisco opened as an 8.5-point favorite on FanDuel Sportsbook.

Take a look at the best Seahawks odds and 49ers odds for the 2022 NFL season.

Seahawks vs 49ers Implied Score

49ers 25.5, Seahawks 17

The Seahawks scored exactly 17 points in their season-opening win over the Broncos. San Francisco managed only 10 in Week 1, but averaged 25.3 points per game a season ago.

Seahawks vs 49ers Pick of the Day

Read more on this Seahawks vs 49ers bet below.

Seahawks vs 49ers Matchup

The Niners looked poised to cakewalk after building a 10-0 second-half lead over the Bears. But between the loss of running back Elijah Mitchell, who will reportedly miss two months due to a sprained MCL, and the tricky weather, San Francisco couldn’t stop the Chicago onslaught. San Francisco clearly missed tight end George Kittle, who did not play due to a groin injury.

The Seahawks meanwhile showcased a tour-de-force defensive performance in Russell Wilson‘s return to the Pacific Northwest, stymieing the veteran QB and Denver’s offense in four red-zone trips even after they lost safety Jamal Adams to a serious knee injury. Seattle surrendered 433 yards, but only allowed two field goals and Jerry Jeudy‘s 67-yard TD catch.

Seahawks vs 49ers Prediction

49ers 27, Seahawks 6

The Seahawks offense didn’t exactly light the world on fire, even though Smith did make some plays. With the opportunity to expand its lead, Seattle managed just 44 yards and no points in four second-half drives and ended the game with only 253 total yards.

The Seahawks defense, fueled by crowd energy that was amped up due to Wilson’s return, bent but didn’t break, and they also got some help from Denver’s lackadaisical clock management.

This was, to some degree, the Seahawks’ Super Bowl, and they came out flying. It might seem hard to believe Seattle would get more fired up for an interconference game than its division opener, but I fully expect the Seahawks to suffer a letdown in Santa Clara.

Meanwhile, the Niners are undoubtedly desperate to show their Week 1 loss was a fluke, and Lance, who fell to 0-2 on the road in his young career, must be pining for the friendly confines of home.

San Francisco still managed 176 rushing yards, even despite Mitchell’s absence, as Lance and Deebo Samuel, who found the end zone in the 49ers’ season opener, each surpassed the 50-yard threshold. The 49ers should still be able to run it with Jeff Wilson, Jr., especially with Adams expected to miss significant time.

The San Francisco defense shot itself in the foot with drive-extending penalties in the second half, but was otherwise strong. Expect Nick Bosa to get after Smith all afternoon and make it hard for him to get settled.

Seahawks vs 49ers Bet Tips

Here are some Seahawks vs 49ers betting tips to consider before placing your any wagers.

  • The Seahawks have won four straight games in this series and three in a row at Levi’s Stadium.
  • The 49ers have covered the spread in each of their past four home games, including a 23-7 win over the Houston Texans in Lance’s lone home start a year ago.
  • Smith is now 4-0 against the spread in four career starts as the Seahawks’ starting quarterback and 21-13-1 in his career ATS despite a 14-21 win/loss record.

Seahawks vs 49ers Best Bets

Under 41.5 Total Points (-115) at FanDuel Sportsbook

Wager: 1 Unit

These teams combined for 27 points in their season openers, and although I fully expect the 49ers to break out offensively, the Seahawks offense we saw in the second half is more likely to be what that unit is throughout the regular season.

Before placing this bet, be sure to consult our best Seattle Seahawks promotions.

49ers -8.5 (-110) at FanDuel Sportsbook

Wager: 1 Unit

I have a front-row seat on the San Francisco bandwagon and am not relinquishing it yet. If the 49ers fail to cover at home against the Seahawks, then maybe it’ll be time to reassess what they are. But until that happens, I’m staying on the train.

Seahawks vs 49ers Props

49ers 1H -5 (-120) at FanDuel Sportsbook

San Francisco built a 10-0 lead against the Bears and should be able to get off to an equally hot start in its home opener. As stated above, the Seahawks offense should struggle.

Before placing this bet, be sure to consult our best San Francisco 49ers promos.

49ers To Score First and Win (-122) at FanDuel

If you like the Niners to cover the first-half spread, it’s pretty safe to assume they’ll be the first team to score too. Weird things can happen to mess this up, but given the odds and prospects, this is a good prop to target.

Seahawks vs 49ers Parlays

49ers -6.5, Under 46.5 Total Points, Seahawks Under 15.5 Total Points (+158) at FanDuel Sportsbook

This isn’t the sexiest or most lucrative pick, but given the angst associated with spread + under parlay betting, we decided to remain modest in hopes that this one will hit.

If you believe the Seahawks team total Under is a sure bet, you could go as low as 40.5 in the full game Over/Under, or raise the spread higher to 9.5 or so. In this parlay, a 31-14 San Francisco win would pay out.


Pat Pickens

Pat Pickens is a seasoned sportswriter who has covered the NHL since 2013 for various websites, including The New York Times,,, USA Today, the Associated Press and many others. His debut book, titled "The Whalers" about the history of the NHL's Hartford Whalers, was released in October 2021. His greatest successful wager was an LA Kings puck-line bet (+200) in Game 1 of the 2012 Western Conference Final.

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