The San Francisco 49ers will host the Seattle Seahawks in Week 14 of the NFL regular season.
San Francisco is coming off its most significant win of the season, while Seattle enters the week looking to avoid its fourth straight loss.
These NFC West rivals faced one another just two weeks ago, and the 49ers defeated Pete Carroll’s squad 31-13.
Let’s look at NFL Week 14 odds, predictions and best bets for the Seahawks vs the 49ers.
Seahawks vs 49ers Odds
NFL odds used for this Seattle vs San Francisco preview were found at DraftKings Sportsbook and are current as of Dec. 5 at 1 p.m. ET.
- Moneyline: 49ers (-575) • Seahawks (+425)
- Spread: 49ers -10.5 (-110) • Seahawks +10.5 (-110)
- Total Points: Over 47 (-110) • Under 47 (-110)
- Implied Score: 49ers 34, Seahawks 23.5
Seahawks vs 49ers Predictions
Score Pick: 49ers 37, Seahawks 20
The 49ers’ 42-19 victory over the Philidelphia Eagles – its opponent from last year’s NFC Championship Game – marked the fourth straight win for Kyle Shanahan’s squad.
The Seahawks, meanwhile, will have 10 days of rest entering this matchup after losing to the Dallas Cowboys on Thursday Night Football.
Things didn’t turn out so hot for the Seahawks when these teams faced each other the first time. Starting quarterback Geno Smith entered the Week 12 matchup with what was eventually diagnosed as a tricep contusion in his throwing arm.
The quarterback denied the injury played any part in his 180-yard, one-interception performance at the end of November.
However, the 2013 second-round draft pick seems to be in much better health this time around. Smith comes into this game after a monstrous 334-yard, three-touchdown performance against the Dallas Cowboys.
Smith will need to replicate last week’s performance if his team is to have any chance of taking down the mighty 49ers.
San Francisco looks like the team to beat in the NFC this season. Despite suffering three-straight losses earlier in the season, the 49ers have bounced back and appear stronger than ever after last week’s dominant victory.
Apart from having one of the best defenses in the league, the San Francisco offense, led by Brock Purdy, has looked as good as any.
Whether it’s Brandon Aiyuk and George Kittle killing you through the air, or the dual threats in Christian McCaffrey and Deebo Samuel attacking the defense in different ways, Shanahan’s offense has seemed virtually unstoppable in recent weeks.
They will be up against a Seahawks defense that just allowed 41 points. Even if Smith and the Seattle offense can repeat last week’s performance, Carroll’s defensive unit must be far stouter if his team is to have a chance.
In the end, the 49ers should be too much for the Seahawks to handle and will run away with the game fairly easily.
Seahawks vs 49ers Best Bets & Props
49ers -10.5 (-110)
DraftKings Sportsbook • WAGER: 2 units
With the moneyline odds being so heavily skewed, taking San Francisco to win in an 11+ point blowout is the more profitable option and my NFL bet of the day.
Seattle is clearly in the midst of a slump, and facing arguably the best team in the league isn’t going to help with that.
The 49ers managed to win their last game against Seattle by 18 points, and their offense seems to have reached a whole new level since that game.
The Seahawks may be able to keep things close at first, but San Francisco should have no trouble pulling away.
Over 47 (-110)
DraftKings Sportsbook • WAGER: 1 unit
Both teams have a wide receiver coming into this game after scoring three touchdowns last week. While the 49ers’ defense will surely be far more difficult to attack than Dallas’, Seattle certainly has the talent to do it.
The Seahawks could also be receiving reinforcements on the offensive end with Kenneth Walker III expected to return after missing last week with an oblique strain.
If Seattle can contribute some points towards the total, the 49ers can surely carry the brunt of the load to help hit the Over.
49ers Over 30.5 (+114)
DraftKings Sportsbook • WAGER: 1.5 units
San Francisco to score Over 30 at +114 is great value given what we’ve seen from this squad in recent weeks.
Shanahan’s team managed to accomplish this against this same Seahawks defense just two weeks ago on the road.
Coming back home after putting up 42 in their last appearance, the 49ers should have no trouble eclipsing this total – they have also scored 31 or more in three of their last four games.
Seahawks vs 49ers Same-Game Parlay
Seahawks vs 49ers SGP (+270)
DraftKings Sportsbook • WAGER: 0.5 units
- 49ers -10.5 (-110)
- 49ers Over 32.5 (+154)
- Over 47 (-110)
Combining all three of our best bets into a Seahawks vs 49ers same-game parlay provides juiced odds that should be fairly manageable.
Rather than staying with the 49ers Over 30.5, taking San Francisco at Over 32.5 provides slightly better odds and is still a possibility based on what we know about this team.
We will need both offenses to continue their recent form and San Francisco to eventually pull away for this to hit.