Cubs vs Cardinals Predictions & Best Bets | Picking Against the Spread

Last Updated: Aug 22, 2022

The Cardinals (68-51) will visit the Cubs (52-67) in Chicago on Monday, August 22 at Wrigley Field. Each team will be eager to come out on top as they work their way through the final third of the regular season. Catch all the action at 7:05 p.m. CT!

This season, the teams have played in 10 contests and the Cubs have claimed victory against their opponents. In their most recent meeting on August 4, 2022, the score was 7-2 in favor of the Cardinals. The Cubs had two runs to the Cardinals six runs. We’ll see what unfolds when it all goes down at Wrigley Field.

Cubs vs Cardinals Prediction

The bookmakers think this should be a win for the Cardinals. FanDuel has them at odds of -172 for victory, while Chicago are +144. The predicted number of total runs is 8.

In their last game on Sunday, the Cubs beat the Brewers by a final score of 2-5. So far this season, the team is currently batting .241 thanks in large part to their top hitter, Nicholas Hoerner, who has a batting average of .294. Defensively, they have an ERA of 4.22 and a .983 fielding percentage.

The last time they played, the Cardinals lost to the Diamondbacks on Sunday by a 4-6 margin. Led by their top hitter, Paul Goldschmidt, who has a batting average of .344, the team is currently batting .256 on the season. In terms of defense, the team has an ERA of 3.82 and a .989 fielding percentage. Don’t forget to consult our odds assessment and make your picks based on the teams’ recent performances!

The latest squad news is that the Cubs will play without Wade Miley (Shoulder), Manuel Rodríguez (Elbow), Kyle Hendricks (Shoulder), Bradley Wieck (Elbow), Patrick Wisdom (Finger), Codi Heuer (Elbow), Michael Hermosillo (Quad), Keegan Thompson (Back), Marcus Stroman (Leg), Adbert Alzolay (Shoulder), Alec Mills (Back), Ethan Roberts (Shoulder) and Jason Heyward (Knee). And the Cardinals will play without Alexander Reyes (Shoulder), Steven Matz (Knee), Jack Flaherty (Shoulder) and Drew VerHagen (Hip).

Moneyline Pick: Cardinals (-172) at FanDuel

The team is considered the favorite according to the betting market. In their previous encounter against these opponents, the Cardinals got the W 7-2.

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Cubs vs Cardinals Betting Odds

  • Moneyline: St. Louis (-172), Chicago (+144) at FanDuel
  • Run Line: St. Louis -1.5 (+100), Chicago 1.5 (-120) at WynnBet
  • Over/Under: Under 8 Runs (-105), Over 8 Runs (-115) at SugarHouse

View all the top MLB betting odds with our awesome lines comparison feature.

Cubs vs Cardinals Betting Trends

  • Win % as favorite: Cubs 0.25%, Cardinals 0.62%
  • Win % as underdog: Cubs 0.45%, Cardinals 0.31%
  • Win-loss record last 10 games: Chicago 6-4, St. Louis 8-2

Runline Pick: Cardinals -1.5 Runs (+100) at DraftKings

Wager: 1 unit

For our spread pick to win, the Cardinals will need to win by the amount of the spread or more in order to cover.

Over/Under Pick: Under 8 Total Runs (-105) at Betfred

Wager: 0.5 units

The Cubs have averaged 4.6 runs per game over their last 10 matches. By comparison, the Cardinals have recorded 4.6 runs during the same period of time.


TGD Computer Picks

The Game Day's staff computer crunches the numbers to create daily bet picks for sports including NFL, NBA, MLB, NHL, soccer, and more.

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