Browns vs Chargers Predictions Week 5 | NFL Pick of the Day

We finally had a down week of predictions in Week 4 as the Los Angeles Rams lost outright to the Arizona Cardinals, but at least we were able to limit the damage by hitting on the Over.

It’s time to turn the page to Week 5, however, and this week we’ll break down a clash of upstart Super Bowl contenders; the Cleveland Browns and Los Angeles Chargers.

Both teams enter Week 5 at 3-1 and tied for first in their respective divisions. The Browns have won three straight since narrowly losing to the Kansas City Chiefs in Week 1, while the Chargers are coming off a big win against the Las Vegas Raiders on Monday Night Football.

This is a huge game between two of the best teams in the AFC, so let’s dive in with our Browns vs Chargers predictions and best bets. Please note that all odds are current as of Friday, October 8.

Sportsbook Play of the Day

Before you make your Browns vs Chargers bet picks, you should know that Caesars Sportsbook is among the industry’s best, offering tons of promotions and a fantastic $5,000 risk-free welcome bonus to new signups using our promo code GAMEDAY.

Read Chris Wassel’s Caesars Sportsbook review for more insight and get your welcome bonus below, or continue reading this analysis for our Cardinals vs Dodgers best bets.

Caesars Sportsbook

Caesars Sportsbook

  • Intuitive App

  • Plenty of Markets & Bet Types

  • VIP Rewards System

Get Up To $5000 Risk-Free

Risk-Free Bonus

GAMEDAYGet bonus

New Customers Only, 21+. T&C’s Apply.

Browns vs Chargers Prediction

Cleveland’s defense is rolling right now after limiting the Chicago Bears and Minnesota Vikings to a combined 13 points over their last two games while racking up 11 sacks. The Browns rank 13th in pass DVOA and 1st in rush DVOA this season, so they’re likely to slow down the Chargers’ offense.

LA’s defense has also been elite, ranking 4th in pass DVOA after holding Derek Carr, Patrick Mahomes, and Dak Prescott to a combined 6.6 yards per pass attempt. Head coach Brandon Staley is a defensive mastermind who will likely make life difficult for Baker Mayfield.

The Browns have a chance to get their running game rolling here, as the Chargers rank 25th in rush DVOA. Nick Chubb and Kareem Hunt should be able to do some damage against this defense.

The problem for Cleveland is that Los Angeles has a significant advantage at quarterback with Justin Herbert. Herbert has been exceptional lately, throwing seven touchdowns with no interceptions over his last two contests. In what should be a close game, I think he’ll lead the Chargers to victory at home.

Prediction: Chargers 24, Browns 19

Myles Garrett and the Cleveland Browns’ defense will try to slow down the Los Angeles Chargers in Week 5. (Image: USA TODAY Sports)

Browns vs Chargers Best Bets

Best Bet: Chargers -2 (-110) at Caesars

Wager: 2 Units



Los Angeles Chargers -2 (CLE @ LAC, NFL Week 5)

CLE @ LAC | 10/10, 4:05 PM ET

Caesars Sportsbook Welcome OfferGet Up To $5,000 Risk-Free
Caesars Sportsbook Logo

Bet $20, Payout $38

I like the fact that we’re getting the team with the better quarterback and home-field advantage at such a low point spread. LA’s defense is just as good as Cleveland’s and I don’t think Mayfield will be able to keep up with Herbert.

Mayfield is coming off a poor outing against the Vikings where he completed only 45.5 percent of his passes at 4.7 yards per attempt, and now he’ll face one of the best pass defenses in football. It’s a bad spot for him, so lay the points with the Chargers.

Best Bet: Under 47.5 Total Points (-115) at WynnBet

Wager: 2 Units



Total Points Under 47.5 (CLE @ LAC, NFL Week 5)

CLE @ LAC | 10/10, 4:05 PM ET

WynnBET Sportsbook Welcome OfferGet Up To $1,000 Risk-Free
WynnBET Sportsbook logo

Bet $20, Payout $37

Starting with Week 1, Browns games have combined for 62, 52, 32, and 21 points this season, while Chargers games have gone for 36, 37, 54, and 42 points. As we can see here, both defenses are fully capable of keeping the game low-scoring.

You also have to consider that if Cleveland is able to run the ball effectively, that will result in longer drives that take more time off the clock, which is good news for the Under and our NFL bet of the day.

Browns vs Chargers Same Game Parlay Picks

  • Chargers -1.5 (-105) at WynnBet
  • Under 47.5 Total Points (-115) at WynnBet

Same Game Parlay Odds: +240

Wager: 1 Unit

prop bet


Chargers -1.5 & Total Under 47.5 (CLE @ LAC, NFL Week 5)

CLE @ LAC | 10/10, 4:05 PM ET

WynnBET Sportsbook Welcome OfferGet Up To $1,000 Risk-Free
WynnBET Sportsbook logo

Bet $20, Payout $68

The Chargers and the Under look like the right side due to Mayfield’s recent struggles as well as the way LA’s offense is clicking right now. The Browns should be able to run the ball against the Chargers’ defense, which will help the Under hit.

It wouldn’t surprise me to see the point spread move more towards Los Angeles, as 1.5 points seem too low for the home team with the better quarterback and a comparable defense. Accordingly, keep an eye on our NFL gameday odds in case the lines shift throughout the week.

Frank’s Betting Record

  • Season: +12.72 Units
  • Week 4: -1.2 Units
  • Week 3: +4.64 Units
  • Week 2: +4.64 Units
  • Week 1: +4.64 Units

Thank you for reading our NFL Week 5 Browns vs Chargers Predictions! For more NFL betting tips, check out our NFL Week 5 Best Bets and NFL Week 5 Parlays Picks.

Related articles

NFL Chubba Hubbard, RB, Carolina Panthers

NFL Week 7 Best Bets | Predictions & Picks for NFL Week 7

Marcus Mosher4 hours ago

Read more


Welcome offer Caesars Sportsbook promotion

Get Up To $5,000 Risk-Free

5 stars
Welcome offer WynnBET Sportsbook promotion

Bet $1, Win $100

5 stars
Welcome offer BetMGM Sportsbook promotion

Get Up To $1,000 Risk-Free

5 stars
Welcome offer DraftKings Sportsbook promotion

Get Up To $1,000 Free 1st Deposit Match

5 stars

Top Offers

Top DFS Offers

Support us