NFL Week 7 Odds & Opening Lines

Last Updated: Jan 23, 2023

Week 7 of the 2022 NFL season offers up 14 games that could prove to be pivotal to some of the early-season’s slow starters.

And while a couple of the league’s top teams are on byes, including the Bills and Eagles, there are still plenty of noteworthy games on the docket.

Here are the current Week 7 NFL odds and lines for the 2022 season.

NFL Week 7 Odds & Lines

Week 7 NFL odds are courtesy of FanDuel Sportsbook unless otherwise noted and are current as of Monday, Oct. 17, at 10:30 a.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 7.

NFL Week 7 Games

New Orleans Saints @ Arizona Cardinals (Thursday Night Football)

Saints +1.5 (-110) @ Cardinals -1.5 (-110)

Week 7 kicks off with a Thursday night showdown in the desert between the Saints and Cardinals. This will be the season debut for Arizona wide receiver DeAndre Hopkins, who was suspended for the first six games of the season.

Expect Kyler Murray to get his favorite target the ball early and often in this one.

Tampa Bay Buccaneers @ Carolina Panthers (Oct. 23, 1 p.m. ET)

Buccaneers -10 (-114) @ Panthers +10 (-106)

This number initially looked too big, but the Buccaneers have won their last four games against the Panthers by 14 points or more.

After taking an unexpected loss in Pittsburgh, Tampa Bay won’t be overlooking anyone. Tom Brady and co. should continue to dominate this NFC South rivalry.

Atlanta Falcons @ Cincinnati Bengals

Falcons +6.5 (-110) @ Bengals -6.5 (-110)

The Bengals were installed as 10-point favorites in this matchup before the year began, but the spread has since dropped through a pair of key numbers. That probably has a bit to do with both teams, as Atlanta has surpassed expectations while Cincinnati hasn’t quite lived up to them.

I’d expect Joe Burrow and Ja’Marr Chase to be too much for this Falcons’ defense, but I’m not betting against Atlanta’s perfect 6-0 ATS record.

Detroit Lions @ Dallas Cowboys

Lions +7 (-115) @ Cowboys -7 (-105)

It may only be October, but this matchup between the Cowboys and Lions has me ready for Thanksgiving Day.

Dallas will look to bounce back after losing to the unbeaten Eagles on Sunday Night Football, and there’s a chance Dak Prescott (thumb) could return. I think taking the points with Detroit coming off a bye is a decent option, but I’d probably stay away until we know more.

New York Giants @ Jacksonville Jaguars

Giants +3 (-115) @ Jaguars -3 (-105)

This line is the definition of fishy.

After losing three straight, the 2-4 Jaguars are three-point home favorites against the 5-1 Giants, who have won three straight.

Despite the records, Jacksonville has a better point differential than New York through six weeks, so I’m not exactly running to bet on Brian Daboll‘s rejuvenated squad.

Indianapolis Colts @ Tennessee Titans

Colts +2.5 (-105) @ Titans -2.5 (-115)

The Colts have won two straight games, which means it is probably time to fade them here against the Titans. Tennessee is coming off a bye and knocked off its AFC South rival 24-17 in Indy back in Week 4. And that was when the Colts had a healthy Jonathan Taylor.

Back Mike Vrabel‘s squad as your NFL play of the day.

Green Bay Packers @ Washington Commanders

Packers -5.5 (-110) @ Commanders +5.5 (-110)

The Packers have actually lost their last two visits to Washington (2016, 2018), but I wouldn’t expect that trend to continue here with Green Bay desperately needing a win after back-to-back defeats. I’m not sure I trust Aaron Rodgers and this offense to cover the spread, but they should get a win over the hapless Commanders.

Cleveland Browns @ Baltimore Ravens

Browns +6.5 (-108) @ Ravens -6.5 (-112)

Lamar Jackson and the Ravens generally overpower bad teams, which has me leaning toward backing Baltimore in a bounce-back spot against the Browns at home. This could be a lower-scoring game, though, especially given Cleveland’s interest in running the football.

Putting the Ravens in a ML parlay or a teaser is probably the most prudent play in this spot.

New York Jets @ Denver Broncos (Oct. 23, 4:05 p.m. ET)

Jets +3.5 (-118) @ Broncos -3.5 (-104)

Week 7 presents a battle of the Wilsons, as Zach Wilson and the Jets will take on Russell Wilson and the Broncos at Mile High. New York was blanked 26-0 by Denver last season, but Robert Saleh‘s squad has made massive improvements on both sides of the ball since then.

Buying the Jets with the hook is tempting after the road win in Green Bay, but I’ll pass for now.

Houston Texans @ Las Vegas Raiders

Texans +7 (-112) @ Raiders -7 (-108)

At first glance, this spread just seems a little too high.

The Texans are capable of keeping games close and Dameon Pierce is a handful on the ground. While the Raiders are the more talented team, this is a tough number to cover.

Both teams are coming off an early-season bye, which could contribute to a hard-fought contest.

Seattle Seahawks @ Los Angeles Chargers

Seahawks +7 (-115) @ Chargers -7 (-105)

The Seahawks are quietly 3-3 and have only lost once by more than seven points. Geno Smith and the offense are capable of trading scores with Justin Herbert and the Chargers, and if Seattle’s defense can actually stop someone like it did Sunday, then Pete Carroll‘s squad should cover.

The Chargers also have a quick turnaround after playing on Monday Night Football.

Kansas City Chiefs @ San Francisco 49ers

Chiefs -3 (-110) @ 49ers +3 (-110)

The Chiefs and 49ers will meet for the first time since Super Bowl 54, in which San Francisco led heading into the fourth quarter but Kansas City ultimately won, 31-20. Jimmy Garoppolo will get another chance to do battle with Patrick Mahomes, with both quarterbacks coming off Week 6 losses.

The 49ers have some injury issues at the moment, especially on defense, so backing the Chiefs on the road makes some sense.

Pittsburgh Steelers @ Miami Dolphins (Sunday Night Football)

Steelers +7 (-115) @ Dolphins -7 (-105)

This is a bigger number than I would have expected to see after Sunday’s results, but baked into it is the likelihood that Dolphins quarterback Tua Tagovailoa returns to action after clearing concussion protocol.

There is also a chance that Steelers rookie Kenny Pickett, who suffered a concussion of his own in Sunday’s win over the Buccaneers, isn’t able to play. Mitchell Trubisky played well in relief, but he wasn’t able to contribute much in his four starts this season.

Adding Miami to a teaser makes a lot of sense, but I’m not comfortable backing either side against the spread given the uncertainty at quarterback.

Chicago Bears @ New England Patriots (Monday Night Football)

Bears +7.5 (-106) @ Patriots -7.5 (-114)

This MNF matchup was supposed to feature two 2021 first-round quarterbacks in Justin Fields and Mac Jones, but the latter has been nursing a high-ankle sprain and may now have trouble getting rookie Bailey Zappe out of the lineup.

Fields has struggled in his sophomore season, and the Bears have given him very little to work with in terms of supporting talent. Chicago has a rest advantage after losing to the Commanders Thursday, but I’m not sure it will make much of a difference in this game.


John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

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