NFL Week 7 Odds | Opening NFL Moneyline, Spread, & Total Betting Lines

Posted: Jul 12, 2022Last updated: Aug 4, 2022

Week 7 of the 2022 NFL season offers up 14 games that could be pivotal to some of the early-season slow starters.

While some of the league’s top teams are on byes, including the Bills and Rams, there are still plenty of noteworthy games on the docket.

Here are the current Week 7 NFL odds and lines for the 2022 season.

NFL Week 7 Odds & Lines

Week 7 NFL odds are courtesy of Betway Sportsbook unless otherwise noted and are current as of Monday, July 18 at 12 p.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 7.

NFL Week 7 Games

New Orleans Saints @ Arizona Cardinals (Thursday Night Football)

Saints +3 (-110) @ Cardinals -3 (-110)

Week 7 kicks off with a Thursday night showdown in the desert between the Saints and Cardinals. This is the expected return date of star wide receiver DeAndre Hopkins, who was suspended for the first six games of the season.

Expect Kyler Murray to get his top wideout the ball early and often in this one. Back the Cardinals at home as your NFL play of the day.

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Tampa Bay Buccaneers @ Carolina Panthers (Oct. 23, 1 p.m. ET)

Buccaneers -5.5 (-110) @ Panthers +5.5 (-110) 

The Buccaneers have won their last four games against the Panthers, with each victory coming by 14 points or more. As long as Tom Brady is around, Tampa Bay should continue to dominate this NFC South rivalry.

Atlanta Falcons @ Cincinnati Bengals 

Falcons +10 (-110) @ Bengals -10 (-110)

These are two teams heading in completely opposite directions. The Falcons are in the early stages of a rebuild, while the Bengals are looking to maximize this winning window with Joe Burrow and a boatload of young talent.

Cincinnati did sleepwalk through some games as heavy favorites last season, however, so I wouldn’t be running to bet this number right now.

Detroit Lions @ Dallas Cowboys

Lions +7 (-110) @ Cowboys -7 (-110)

It may only be October, but this matchup between the Cowboys and Lions has me ready for Thanksgiving Day. Dallas (13-4) and Detroit (11-6) posted two of the three best against-the-spread records in the NFL last season, and it’s hard to figure out which side to back with this line currently sitting on a key number.

New York Giants @ Jacksonville Jaguars

Giants +1.5 (-110) @ Jaguars -1.5 (-110)

Jaguars coach Doug Pederson has plenty of familiarity with the Giants after coaching their NFC East rival Eagles for five seasons. He’s also got the better quarterback in this matchup, as Trevor Lawrence should take a step up in Year 2 and we’re still not quite sure about the long-term future of Daniel Jones

Indianapolis Colts @ Tennessee Titans

Colts PICK (-110) @ Titans PICK (-110)

The two teams with the best odds to win the AFC South meet for the second time in Week 7, having squared off in Indianapolis back in Week 4. The Titans won their home matchup with the Colts last season, ending a streak of three straight defeats to their rival at Nissan Stadium. As the odds project, this game could go either way.

Green Bay Packers @ Washington Commanders

Packers -3.5 (-110) @ Commanders +3.5 (-110)

The Packers have actually lost their last two visits to Washington (2016, 2018), but I wouldn’t expect that trend to continue with Carson Wentz under center for the Commanders. Washington’s defense will have to keep the team in it, but Aaron Rodgers is just too good.

Cleveland Browns @ Baltimore Ravens

Browns N/A @ Ravens N/A

If Deshaun Watson‘s six-game suspension holds, this could be the first time we see the former Texans quarterback suit up for the Browns. Debuting in Baltimore will certainly be challenging, as the rival fans and the Ravens’ exceptional defense will make life difficult for Watson and co.

New York Jets @ Denver Broncos (Oct. 23, 4:05 p.m. ET)

Jets +7.5 (-110) @ Broncos -7.5 (-110)

Week 7 presents a battle of the Wilsons, as Zach Wilson and the Jets will take on Russell Wilson and the Broncos at Mile High. New York was blanked 26-0 by Denver last season, and that was against a Broncos team quarterbacked by Teddy Bridgewater.

This matchup should favor the home team, though don’t rule out the possibility of a Jets’ backdoor cover.

Houston Texans @ Las Vegas Raiders

Texans +8 (-110) @ Raiders -8 (-110) 

At first glance, this spread just seems a little too high. The Texans have proved that they can keep games close with Davis Mills and while the Raiders are the better team, this is a tough number to cover. Both teams are coming off an early-season bye, which could contribute to a hard-fought contest.

Seattle Seahawks @ Los Angeles Chargers

Seahawks +8.5 (-110) @ Chargers -8.5 (-110)

This game feels oddly similar to the one above. The Chargers are rightly favored as they are expected to be a playoff team, while the Seahawks are rebuilding after trading Wilson.

Still, there could be a matchup advantage here for Seattle to exploit on the ground against a Los Angeles side that ranked last in the league in defending the rush last season. If Seahawks’ ground game can have a big day, they should be able to keep this game close.

Kansas City Chiefs @ San Francisco 49ers

Chiefs -1 (-110) @ 49ers +1 (-110)

The Chiefs and 49ers will meet for the first time since Super Bowl 54, in which San Francisco led heading into the fourth quarter but Kansas City ultimately won, 31-20. Some key players from that game won’t be in the picture this time as the 49ers have moved on from Jimmy Garoppolo and the Chiefs traded Tyreek Hill this offseason.

Both teams still remain competitive, however, and this game could certainly go either way.

Pittsburgh Steelers @ Miami Dolphins (Sunday Night Football)

Steelers +4.5 (-110) @ Dolphins -4.5 (-110)

This might’ve been a more interesting matchup 20 years ago, but this spread seems a little short given the state of the teams in 2022. The Steelers have the best odds to finish last in the AFC North, while the Dolphins are expected to make a run at a Wild Card spot. Back the home team in primetime.

Chicago Bears @ New England Patriots (Monday Night Football)

Bears +6 (-110) @ Patriots -6 (-110)

Monday Night Football offers up an intriguing matchup between two quarterbacks taken in the first round of the 2021 NFL Draft. Justin Fields was selected four picks ahead of Mac Jones, but Jones had the better rookie campaign and led his team to the postseason.

A lot of that has to do with the situations around the two young quarterbacks, as Jones definitely has a better supporting cast in New England than Fields does in Chicago. Either way, this should be an entertaining contest between two motivated, young signal-callers.


John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the last two men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

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