NFL Week 3 Odds | Opening NFL Moneyline, Spread, & Total Betting Lines

Posted: Jul 12, 2022Last updated: Aug 5, 2022

Week 3 of the 2022 NFL season features some high-profile matchups, including a potential final showdown between Aaron Rodgers and Tom Brady. We also should know a bit more about each team after watching their first two games.

Here are the current Week 3 NFL odds and lines for the 2022 season.

NFL Week 3 Odds & Lines

Week 3 NFL odds are courtesy of Betway Sportsbook unless otherwise noted and are current as of Tuesday, July 12 at 3 p.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 3.

NFL Week 3 Games

Pittsburgh Steelers @ Cleveland Browns (Thursday Night Football)

Steelers N/A @ Browns N/A

The Steelers swept the Browns in 2021 and have generally dominated this AFC North rivalry under head coach Mike Tomlin, but things could be different this year.

Cleveland boasts better odds to win the division than Pittsburgh and looks more likely to contend for a playoff spot in a crowded AFC.

Sportsbook Play of the Day

Before you make your next NFL Week 3 bet, you should know that Caesars Sportsbook is among the industry’s best, offering tons of promotions. Get up to $1,500 in first bet insurance when you use our promo code .

Read Chris Wassel’s Caesars Sportsbook review for more insight and get your welcome bonus below, or continue reading this NFL Week 3 analysis.

New Orleans Saints @ Carolina Panthers (Sept. 25, 1 p.m. ET)

Saints -1 (-110) @ Panthers +1 (-110)

The Panthers have lost nine of their last 11 games against the Saints, but the two teams did split their season series last year. Carolina’s defense was the star in their first meeting, limiting Jameis Winston and co. to 128 total yards in a 26-7 victory.

Odds are, that’s not going to happen again, especially with Michael Thomas and rookie Chris Olave adding to New Orleans’ offensive firepower.

Houston Texans @ Chicago Bears

Texans +3 (-110) @ Bears -3 (-110)

This will be the sixth all-time meeting between the Texans and Bears. Houston won the first four matchups while the Bears won the most recent one, but both teams look drastically different even from that 2020 showdown.

Neither of these two rosters is in particularly good shape, but I’d probably trust Justin Fields over Davis Mills at this point in their careers.

Kansas City Chiefs @ Indianapolis Colts

Chiefs -2.5 (-110) @ Colts +2.5 (-110)

The Chiefs enter this Week 3 matchup with a few days extra rest after facing the Chargers on Thursday Night Football, but they’ll have to travel to Indianapolis for the Colts’ home opener.

Look for Patrick Mahomes to play spoiler to Matt Ryan’s home debut with his new team.

Buffalo Bills @ Miami Dolphins

Bills -3.5 (-110) @ Dolphins +3.5 (-110)

The Bills outscored the Dolphins 61-11 across two meetings last season, including a 35-0 victory in Miami.

Given that information, this spread looks a little small, after considering the additions of Tyreek Hill and others to Miami’s offense this offseason.

Detroit Lions @ Minnesota Vikings

Lions +6.5 (-110) @ Vikings -6.5 (-110)

The Lions only won three games last season, however, one of those victories came against the Vikings. Minnesota had won the eight prior matchups and still hasn’t lost to Detroit at home in the Kirk Cousins era.

While that bodes well for Minnesota getting the victory, I’m not sure I’d lay this many points with the Vikings right now.

Baltimore Ravens @ New England Patriots

Ravens PICK (-110) @ Patriots PICK (-110)

The Ravens and Patriots have arguably been the two top franchises in the AFC since the turn of the century, but Baltimore is undoubtedly the better team right now.

These odds don’t make much sense to me. Trust Lamar Jackson and the Ravens to get the job done in Foxborough.

Cincinnati Bengals @ New York Jets

Bengals -5 (-110) @ Jets +5 (-110) 

The low point of the Bengals’ 2021 season arguably came at MetLife Stadium in a shocking 34-31 defeat to the Mike White-led New York Jets. White threw for more than 400 yards that day, taking advantage of a Cincinnati defense that was clearly sleepwalking through that contest.

The odds of another letdown performance like that, especially since head coach Zac Taylor has all the bulletin board material he could need, is very slim. Back the Bengals on the road with confidence.

Las Vegas Raiders @ Tennessee Titans

Raiders +1 (-110) @ Titans -1 (-110) 

Although it’s only Week 3, this could be a pivotal intraconference game for the Titans and Raiders as they fight for positioning in a loaded AFC.

Tennessee went 7-2 at home last season and will be tough to beat.

Philadelphia Eagles @ Washington Commanders

Eagles PICK (-110) @ Commanders PICK (-110) 

While people tend to question the long-term potential of Jalen Hurts, he’s certainly a better quarterback than Carson Wentz.

The Eagles swept Washington last year and should be able to take down their NFC East rival again in Week 3.

Jacksonville Jaguars @ Los Angeles Chargers (Sept. 25, 4:05 p.m. ET)

Jaguars +10 (-120) @ Chargers -10 (+100)

The biggest spread of the week sees the Chargers open as 10-point home favorites against the Jaguars. And while I can see why Los Angeles is heavily favored, these odds just don’t feel right.

This Jacksonville squad should be better this season under Doug Pederson, who will help Trevor Lawrence improve in Year 2. This is just way too big of a number for the Chargers to cover.

Los Angeles Rams @ Arizona Cardinals

Rams -2 (-110) @ Cardinals +2 (-110)

The Rams ended the Cardinals’ season in embarrassing fashion in the Wild Card round last year, so this is certainly a date Kliff Kingsbury and co. have circled on their calendar.

Kyler Murray will have to perform better under pressure than he did in that matchup if he wants to lead Arizona to an upset win.

Atlanta Falcons @ Seattle Seahawks

Falcons +3.5 (-110) @ Seahawks -3.5 (-110)

The Falcons and the Seahawks are evenly matched, but not for good reasons. Both entered the season as the odds-on favorite to finish last in their respective divisions.

I’ve got a little more faith in Pete Carroll and the Seahawks, but I don’t like being on the wrong side of the hook here.

Green Bay Packers @ Tampa Bay Buccaneers

Packers +3.5 (-110) @ Buccaneers -3.5 (-110)

Could this be the last time we see Brady and Rodgers share the field together? It’s a possibility, though I’ll certainly be rooting for one last playoff meeting between the two come January.

In that situation, I’d trust Brady and the Buccaneers. In September, I’ll be taking the points with Green Bay as my NFL pick of the day.

San Francisco 49ers @ Denver Broncos (Sunday Night Football)

49ers +2.5 (-110) @ Broncos -2.5 (-110)

The Broncos return to primetime for the second time in three weeks after opening the season on Monday Night Football. After facing a couple of cupcakes, this will be Russell Wilson’s first real test against a former division rival.

Wilson has tormented 49ers fans over the years, going 16-4 against San Francisco during his time in Seattle. Expect the rejuvenated Broncos to cover this short spread on SNF.

Dallas Cowboys @ New York Giants (Monday Night Football)

Cowboys -4 (-110) @ Giants -4 (-110)

The first NFC East matchup for both the Cowboys and Giants comes in Week 3 on Monday Night Football. Dallas convincingly swept the season series against New York last year, outscoring the G-Men 65-26.

This is a different New York squad under Brian Daboll, but I don’t think the Giants will prove to be much of a road block in this one.


John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the last two men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

Related articles