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NFL Week 3 Odds & Opening Lines

Posted: Sep 20, 2022Last updated: Jan 23, 2023

Week 2 of the NFL season was highlighted by some crazy comebacks, as the Cardinals, Dolphins, and Jets erased deficits that all seemed insurmountable.

Now, what will Week 3 have in store for us? Well, we know that there will be some high-profile matchups, including a potential final showdown between Aaron Rodgers and Tom Brady.

Below are the current Week 3 NFL odds and lines for the 2022 season. Let’s dig in to see what early-week bets we should be making.

NFL Week 3 Odds & Lines

Week 3 NFL odds are courtesy of FanDuel Sportsbook unless otherwise noted and are current as of Monday, Sept. 19 at 12 p.m. ET. Be sure to keep tabs on all of the current NFL odds leading into NFL Week 3.

NFL Week 3 Games

Pittsburgh Steelers @ Cleveland Browns (Thursday Night Football)

Steelers +3.5 (-114) @ Browns -3.5 (-106)

Both teams are 1-1 after falling in Week 2. Pittsburgh never led in a three-point home loss to the Patriots, while Cleveland threw away a 13-point advantage in the final two minutes of the fourth quarter to lose 31-30 to the Jets.

The Steelers swept the Browns in 2021 and have generally dominated this AFC North rivalry under head coach Mike Tomlin, but this Pittsburgh team has concerns at quarterback. Mitch Trubisky hasn’t cracked 200+ passing yards in either of his first two starts, which has fans already chanting for rookie Kenny Pickett.

Still, it’s hard to imagine laying the points with Cleveland here after that debacle.

New Orleans Saints @ Carolina Panthers (Sept. 25, 1 p.m. ET)

Saints -3 (-106) @ Panthers +3 (-114)

Two more teams coming off a Week 2 loss will square off when New Orleans visits Carolina in an NFC South clash. The Panthers have lost nine of their last 11 games against the Saints, but the two teams did split their season series last year.

Carolina’s defense was the star in their first meeting, limiting Jameis Winston and co. to 128 total yards in a 26-7 victory. Winston threw three interceptions on Sunday against Tampa Bay, but should be in a good spot to bounce back against the 0-2 Panthers.

I’d avoid the spread on this key number, though, as Carolina has lost its first two games by a combined five points.

Houston Texans @ Chicago Bears

Texans +2.5 (-104) @ Bears -2.5 (-118)

The Texans and Bears were undefeated heading into Week 2, but both suffered frustrating losses on Sunday.

Houston’s defense shut down Russell Wilson and the Broncos for long stretches, but Davis Mills and the offense couldn’t capitalize in a 16-9 defeat in Denver. Meanwhile, Chicago’s offense showed some promise on the ground Sunday night in Green Bay, but trusted Justin Fields to throw just 11 passes in a 27-10 loss.

Neither of these two rosters is in particularly good shape, but I’d probably trust the Texans to cover the number if they catch a field goal or more by kickoff.

Kansas City Chiefs @ Indianapolis Colts

Chiefs -6.5 (-115) @ Colts +6.5 (-105)

The Chiefs enter this Week 3 matchup with a few days of extra rest after defeating the Chargers on Thursday Night Football. Patrick Mahomes looked shaky at times in that one, but he should be able to get right this week against a Colts squad that is clearly lacking confidence.

Matt Ryan’s home debut with his new team doesn’t look like it’ll be the occasion Colts fans had hoped it would be at the beginning of the year. Look for KC to pile on the misery for Indy.

Buffalo Bills @ Miami Dolphins

Bills -4.5 (-115) @ Dolphins +4.5 (-105)

The Bills outscored the Dolphins 61-11 across two meetings last season, including a 35-0 victory in Miami. That probably won’t be the case this year, as this is shaping up to be one of the games of the week.

Tua Tagovailoa put up true video-game numbers in Week 2, throwing for 469 yards and six touchdowns as the Dolphins erased a 21-point halftime deficit to stun the Ravens 42-38 in Baltimore. The Dolphins seem legit, but we’ll get a true test of their mettle against the Super Bowl favorites.

Detroit Lions @ Minnesota Vikings

Lions +7 (-114) @ Vikings -7 (-106)

The Lions earned their first win of the season on Sunday against the Commanders, as Amon-Ra St. Brown made NFL history by notching his sixth straight game (dating back to last season) with eight-plus receptions and a touchdown.

Still, Minnesota hasn’t lost at home to Detroit in the Kirk Cousins era and I wouldn’t expect that to start now, even on a short week. While I’m confident in Minnesota getting the victory, I’m not sure I’d lay this many points against a feisty Lions team.

Baltimore Ravens @ New England Patriots

Ravens -3 (-114) @ Patriots +3 (-106)

The Ravens and Patriots have arguably been the two top franchises in the AFC since the turn of the century, but neither look like world beaters right now. Both teams lost to the Dolphins over the first two weeks in very differently played games, so this will be a clash of styles.

I think Baltimore has the better team when healthy, but early-season injuries are mounting.

Cincinnati Bengals @ New York Jets

Bengals -4.5 (-110) @ Jets +4.5 (-110)

The low point of the Bengals’ 2021 season arguably came at MetLife Stadium in a shocking 34-31 defeat to the Mike White-led New York Jets. White threw for more than 400 yards that day, taking advantage of a Cincinnati defense that was clearly sleepwalking through that contest.

The odds of another letdown performance like that, especially since head coach Zac Taylor has all the bulletin board material he could need after a loss to Cooper Rush and the Cowboys, is very slim.

Back the 0-2 Bengals on the road with confidence.

Las Vegas Raiders @ Tennessee Titans

Raiders -1 (-110) @ Titans +1 (-110)

Although it’s only Week 3, this could be a pivotal intraconference game for the Titans and Raiders. If Tennessee loses on Monday night to the Bills, as is expected, both of these teams will be 0-2.

Going 0-3 in a loaded AFC will make reaching the playoffs near impossible, though the Titans have the benefit of playing in the AFC South.

Tennessee went 7-2 at home last season and will be tough to beat.

Philadelphia Eagles @ Washington Commanders

Eagles -4 (-110) @ Commanders +4 (-110)

Carson Wentz revenge game? This will be fun.

The Eagles swept Washington last year and are favored to take down their NFC East rival again in Week 3. I’ll wait to see how Philadelphia looks on Monday night, but I’m considering taking the points with the home dog here.

Jacksonville Jaguars @ Los Angeles Chargers

Jaguars +7 (-110) @ Chargers -7 (-110)

One of the biggest spreads of the week sees the Chargers open as seven-point home favorites against the Jaguars. Los Angeles has a rest advantage in this one, which may have been needed after Justin Herbert (ribs) got roughed up against the Chiefs on Thursday night.

I’m going to wait and see what his and Keenan Allen‘s status are before laying the points with LA here.

Los Angeles Rams @ Arizona Cardinals

Rams -4.5 (-110) @ Cardinals +4.5 (-110)

The Rams ended the Cardinals’ season in embarrassing fashion in the Wild Card round last year, so this is certainly a date Kliff Kingsbury and co. have circled on their calendar.

Both teams bounced back from blowout losses in Week 1 to get to .500 on Sunday, but the Rams definitely looked better in doing so, despite letting the Falcons back in the game late. I trust Matthew Stafford and Cooper Kupp to get another win over their division rival.

Atlanta Falcons @ Seattle Seahawks

Falcons +1.5 (-110) @ Seahawks -1.5 (-110)

The Falcons and the Seahawks are evenly matched, but not for good reasons. Both entered the season as the odds-on favorite to finish last in their respective divisions.

Atlanta showed some fight in Week 2 against the Rams, while Seattle failed to put up much opposition against the 49ers. I could see Marcus Mariota and the Falcons winning this game outright.

Green Bay Packers @ Tampa Bay Buccaneers

Packers +3 (-118) @ Buccaneers -3 (-104)

Could this be the last time we see Brady and Rodgers share the field together? It’s a possibility, though I’ll certainly be rooting for one last playoff meeting between the two come January.

In that situation, I’d trust Brady and the Buccaneers. In September, I’ll be taking the points with Green Bay, especially with Mike Evans suspended.

San Francisco 49ers @ Denver Broncos (Sunday Night Football)

49ers -1 (-110) @ Broncos +1 (-110)

The Broncos return to primetime for the second time in three weeks after losing their season opener to the Seahawks on Monday Night Football. Russell Wilson has tormented 49ers fans over the years, going 16-4 against San Francisco during his time in Seattle, but he has looked terrible thus far in Denver.

The Niners rallied after Trey Lance‘s unfortunate season-ending injury in Week 2, and Jimmy Garoppolo is more than capable of leading this team to a primetime road win. My early lean is San Francisco.

Dallas Cowboys @ New York Giants (Monday Night Football)

Cowboys +3 (-114) @ Giants -3 (-106)

The first NFC East matchup for both the Cowboys and Giants comes in Week 3 on Monday Night Football. Dallas convincingly swept the season series against New York last year, outscoring the G-Men 65-26.

However, the 2022 Giants are 2-0 under Brian Daboll, and they’ve got a great chance of getting to 3-0 against a Cowboys team playing with a backup quarterback. This game should be close, so I’m staying away from any spread bets on this key number.

Author

John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the last two men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

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