NFL Week 16 Odds

Frank AmmiranteSenior Sports Writer
Last Updated: Dec 18, 2023

We will be treated to four days of holiday action in NFL Week 16. Naturally, playoff possibilities will dominate the storylines, with games like New Orleans Saints-Los Angeles Rams, Cincinnati Bengals-Pittsburgh Steelers, and Cleveland Browns-Houston Texans having huge implications for the postseason.

We also have a pair of compelling clashes between NFC and AFC projected heavyweights, as the Dallas Cowboys take on the Miami Dolphins and the Baltimore Ravens meet the San Francisco 49ers on Monday Night Football.

NFL Week 16 Odds & Lines

Week 16 lines are courtesy of FanDuel Sportsbook and are current as of December 18, 2023, at 10 a.m. ET.

Keep tabs on all of our current NFL odds leading into NFL Week 16.

NFL Week 16 Games

New Orleans Saints @ Los Angeles Rams

Dec. 21, 8:15 p.m. ET (TNF)

Saints +4 (-110) @ Rams -4 (-110)

Both the Saints and Rams need a win to keep their playoff chances afloat.

I give the edge to the Rams because they’ve been a much better team with running back Kyren Williams in the lineup, winning four of their last five games.

Look for Los Angeles to keep it rolling with another home win.

Cincinnati Bengals @ Pittsburgh Steelers

Dec. 23, 4:30 p.m. ET (Saturday)

Bengals -2 (-110) @ Steelers +2 (-110)

Jake Browning has done an admirable job filling in for Joe Burrow, leading the Bengals to a three-game winning streak.

While the Steelers are reeling, having lost three in a row, you can always count on a Mike Tomlin team to play well in a divisional home game.

Bet on Pittsburgh getting the upset in this one.

Buffalo Bills @ Los Angeles Chargers

Dec. 23, 8:30 p.m. ET (Saturday)

Bills -13.5 (-110) @ Chargers +13.5 (-110)

The Buffalo Bills are rolling, winning three of their last four games, highlighted by a Week 15 blowout victory over the Dallas Cowboys.

The Chargers are playing their first game since firing head coach Brandon Staley. We’ve often seen teams respond well in such circumstances.

We’re getting a lot of points here, so look for Easton Stick and the Chargers to cover the spread in this spot.

Detroit Lions @ Minnesota Vikings

Dec. 24, 1 p.m. ET

Lions -3.5 (-105) @ Vikings +3.5 (-115)

The Detroit Lions got back on track with a convincing home win over the Denver Broncos, while the Minnesota Vikings absolutely blew the game against the Bengals.

You always like getting the hook on the home underdog in a divisional game, as we do with Minnesota here.

I’m projecting a close game that comes down to the wire, so let’s ride the Vikings.

Seattle Seahawks @ Tennessee Titans

Dec. 24, 1 p.m. ET

Seahawks -2.5 (-110) @ Titans +2.5 (-110)

Here we have two teams with question marks at quarterback, as Geno Smith and Will Levis could miss this game, leaving Drew Lock and Ryan Tannehill to go at it in this inter-conference matchup.

I’ll keep it simple and go with the team with slim playoff hopes in the Seahawks, who can seal a win over a Titans side that is just playing out the year.

Look for Seattle to get it done in a close game.

Indianapolis Colts @ Atlanta Falcons

Dec. 24, 1 p.m. ET

Colts -1.5 (-110) @ Falcons +1.5 (-110)

The Indianapolis Colts continue to win games despite playing with Gardner Minshew at quarterback, demonstrating that Shane Steichen is a terrific head coach.

On the other side, Arthur Smith keeps failing to get the ball in the hands of his playmakers, most recently limiting Bijan Robinson‘s touches in favor of Tyler Allgeier.

The Colts have the coaching advantage, so we’ll take them to get another win on the road.

Washington Commanders @ New York Jets

Dec. 24, 1 p.m. ET

Commanders +3 (-110) @ Jets -3 (-110)

Here we have a matchup of two teams that are playing out the season, but the New York Jets have a slight edge.

The Washington Commanders have been horrendous since their 2-0 start, going 2-10 in their last 12 games.

Washington is going to have a tough time with this Jets pass defense.

Green Bay Packers @ Carolina Panthers

Dec. 24, 1 p.m. ET

Packers -4.5 (-110) @ Panthers +4.5 (-110)

The Green Bay Packers have almost squandered their playoff hopes with consecutive losses to the New York Giants and Tampa Bay Buccaneers in games in which they were favored.

This has the look of an ugly road game, and the Carolina Panthers are likely to play run-heavy, feeding Chuba Hubbard to take pressure off rookie Bryce Young.

I’ll take Carolina to keep this one close.

Cleveland Browns @ Houston Texans

Dec. 24, 1 p.m. ET

Browns +2.5 (-110) @ Texans -2.5 (-110)

Joe Flacco has done a fantastic job filling in as the Cleveland Browns’ quarterback, leading the team to back-to-back wins, including a comeback victory over the Bears in Week 15.

It’s unclear if C.J. Stroud will be back for this game, but I’ll bet on the promising rookie returning. The Houston Texans just got a huge win with Case Keenum on the road.

Look for the Texans to make it two in a row against the Browns.

Jacksonville Jaguars @ Tampa Bay Buccaneers

Dec. 24, 4:05 p.m. ET

Jaguars +1.5 (-120) @ Buccaneers -1.5 (-102)

The Jacksonville Jaguars are reeling right now, dropping three in a row. Trevor Lawrence (concussion) may be forced to miss this game.

Meanwhile, the Bucs have won three in a row, including a huge road win over the Packers last week.

I’ll take Tampa to win because I’m projecting Lawrence to be unavailable, forcing C.J. Beathard into action.

Arizona Cardinals @ Chicago Bears

Dec. 24, 4:25 p.m. ET

Cardinals +4.5 (-115) @ Bears -4.5 (-105)

The Chicago Bears continue to look much better on defense, but it’s hard to lay 4.5 points considering the way they’ve blown games this season, most recently against the Browns last week.

While the Arizona Cardinals are one of the worst teams in the NFL, I’ll take my chances that Kyler Murray will be able to keep it relatively close.

Take the Cards to cover the spread.

Dallas Cowboys @ Miami Dolphins

Dec. 24, 4:25 p.m. ET

Cowboys +1.5 (-110) @ Dolphins -1.5 (-110)

The Cowboys will look to bounce back after a disappointing performance on the road against the Buffalo Bills last week.

Miami hasn’t been able to knock off playoff contenders all year, losing to teams like the Bills, Kansas City Chiefs, and Philadelphia Eagles.

We’ll bet on that trend continuing with another loss, this time to the Cowboys.

New England Patriots @ Denver Broncos

Dec. 24, 8:15 p.m. ET (SNF)

Patriots +6 (-110) @ Broncos -6 (-110)

We’ve got an ugly game on tap for Sunday Night Football with the Denver Broncos at home to the bottom-feeding New England Patriots.

Denver badly needs this win to stay in the AFC wild-card race, so look for Russell Wilson and company to get it done against Bailey Zappe and the Patriots.

I’ll take the Broncos to cover the spread.

Las Vegas Raiders @ Kansas City Chiefs

Dec. 25, 1 p.m. ET (Monday)

Raiders +10 (-110) @ Chiefs -10 (-110)

The Chiefs got back on track with a convincing win over the Patriots last week, while the Las Vegas Raiders absolutely blew out the Chargers.

I’ll bet on Vegas crashing back to Earth. Look for Patrick Mahomes to continue to find promising rookie wideout Rashee Rice early and often.

Take the Chiefs -10 in this favorable spot at home.

New York Giants @ Philadelphia Eagles

Dec. 25, 4:30 p.m. ET (Monday)

Giants +10.5 (-110) @ Eagles -10.5 (-110)

The Giants are in a tough spot on the road against the Eagles.

The Tommy DeVito magic appeared to wear off in their loss to the Saints on the road.

Bet on Philly’s defense to cause problems for the Giants.

Baltimore Ravens @ San Francisco 49ers

Dec. 25, 8:15 p.m. ET (MNF)

Ravens +4.5 (-110) @ 49ers -4.5 (-110)

We’ve got a potential Super Bowl preview between the Ravens and 49ers.

While Baltimore has been impressive all year long, the 49ers are in their own tier right now. San Francisco continues to blow out opponents, and Brock Purdy has been phenomenal as the facilitator in this offense.

Take the 49ers to win this one by five or more points.


Frank Ammirante

Frank Ammirante is a Senior Sports Writer at The Game Day. Previously, he wrote for 4for4 Football and RotoBaller. Frank is a member of the Fantasy Sports Writer's Association while maintaining an active presence within the community. He has competed in industry contests like the Scott Fish Bowl, The Great Fantasy Baseball Invitational, and more. Frank will be making his debut in Tout Wars this year. He's got a diverse sporting background, but specializes in football and baseball.

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