NFL Week 16 Odds & Opening Lines

Last Updated: Jan 3, 2023

Given the construction of the NFL calendar, we don’t always get NFL games on Christmas Day.

But with Christmas falling on a Sunday in 2022, the league has gifted us a triple-header as part of a loaded Week 16 slate.

To avoid having overlapping games on during the holiday, the majority of this week’s matchups will take place on Christmas Eve. But don’t worry, there will still be games on Thursday night and Monday night if you’re looking to sneak away from family time.

Here are the current Week 16 NFL odds and lines for the 2022 season.

Week 16 NFL Odds & Lines

Week 16 NFL odds are courtesy of Caesars Sportsbook unless otherwise noted and are current as of Monday, Dec. 19 at 10:30 a.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 16.

Week 16 NFL Games

Jacksonville Jaguars @ New York Jets (Thursday Night Football)

Jaguars +1 (-110) @ Jets -1 (-110)

Week 16 kicks off on Thursday night with an intriguing intraconference matchup that surprisingly has postseason implications. The surging Jaguars are only a game back of the AFC South-leading Titans, while the Jets are still within touching distance of the final wild-card spot.

These two teams have been heading in opposite directions of late, and it’s hard to trust Zach Wilson against Trevor Lawrence in a battle of the top two picks from the 2021 NFL Draft.

Atlanta Falcons @ Baltimore Ravens (Dec. 24, 1 p.m. ET)

Falcons +7 (-110) @ Ravens -7 (-110)

Desmond Ridder didn’t do much in his NFL debut last week and facing this stout Ravens defense won’t be easy. Baltimore is also expected to get quarterback Lamar Jackson (knee) back on Saturday, which should provide a major boost to an offense that managed just three points in a Week 15 loss to Cleveland.

I’m not sure I want to lay seven points here, but it’s Baltimore or nothing for me.

Detroit Lions @ Carolina Panthers

Lions -3 (-110) @ Panthers +3 (-110)

There’s no denying that the Lions are one of the hottest teams in football right now and it’s simply stunning that Detroit has a chance to make the playoffs after starting 1-6.

However, this spread has probably gone a bit too far, and I think Carolina can match up pretty well with Dan Campbell‘s squad. Give me the Panthers, who still have a shot to win the NFC South, and the points.

Buffalo Bills @ Chicago Bears

Bills -9 (-110) @ Bears +9 (-110)

The Bills have clinched a playoff spot and can wrap up another AFC East division title with a win over the Bears on Christmas Eve. Perhaps more importantly, Buffalo still needs to keep pace with Kansas City in the race for the conference’s No. 1 seed.

No matter the motivation, the Bills should have enough to beat the Bears, but Justin Fields could keep this close enough to cover the spread.

Seattle Seahawks @ Kansas City Chiefs

Seahawks +9.5 (-110) @ Chiefs -9.5 (-110)

As good as Patrick Mahomes and the Chiefs have been in recent years, they haven’t always been great at covering these huge numbers. Last week’s 30-24 overtime victory over the one-win Texans is just another example.

Seattle has been on a downward trend lately, but Pete Carroll‘s squad has extra rest after playing on TNF and this number is just too big.

New York Giants @ Minnesota Vikings

Giants +3.5 (-110) @ Vikings -3.5 (-110)

The Vikings pulled off the biggest comeback in NFL history on Saturday, erasing a 33-0 halftime lead to stun the Colts, 39-36. After clinching the NFC North in such a dramatic fashion, there is definitely the potential for an emotional letdown here against a much tougher opponent.

Getting three and the hook here with the Giants feels like a steal.

Cincinnati Bengals @ New England Patriots

Bengals -3.5 (-110) @ Patriots +3.5 (-110)

The Patriots have won three straight against the Bengals, but this will be Bill Belichick‘s first time scheming for Joe Burrow and Ja’Marr Chase. It will also be interesting to see how this New England reacts after suffering one of the most deflating, shocking losses imaginable.

The defending AFC champions are favored on the road for a reason.

Houston Texans @ Tennessee Titans

Texans +7 (-110) @ Titans -7 (-110)

Derrick Henry flat-out owns the Houston Texans. The Titans running back has run for 892 yards and nine touchdowns in his last four games against Houston, dating back to 2019.

Expect another big day from King Henry and for Tennessee to get a much-needed victory.

New Orleans Saints @ Cleveland Browns

Saints +3 (+100) @ Browns -3 (-120)

This should be a defensive struggle.

I don’t particularly trust either of these offenses and both teams are coming off uninspiring wins in Week 15. This is a pure stay-away game for me, especially with the spread sitting on a key number.

Washington Commanders @ San Francisco 49ers (Dec. 24, 4 p.m. ET)

Commanders +7 (-110) @ 49ers -7 (-110)

Taylor Heinicke is prone to the occasional turnover, which could prove to be deadly against this San Francisco defense, but I think the Commanders can keep this game close

Washington pass-rusher Chase Young (knee) could make his season debut Saturday, and eventually, this Niners’ run of covering games has to come to an end. Give me the points here.

Philadelphia Eagles @ Dallas Cowboys

Eagles +1.5 (-110) @ Cowboys -1.5 (-110)

The Eagles have already clinched a playoff spot and the NFC East could be next if they complete a season sweep of the Cowboys Saturday.

Dak Prescott has to play turnover-free football, but if he does, I think Dallas will win this marquee matchup.

Las Vegas Raiders @ Pittsburgh Steelers (Dec. 24, 8:15 p.m. ET)

Raiders +2 (-110) @ Steelers -2 (-110)

I’m not sure a battle of 6-8 teams was exactly what I wanted on the night before Christmas, but you get what you get and you don’t get upset.

The Steelers have been torched by some high-powered passing attacks this season, so I’d lean toward backing the Raiders now that Darren Waller and Hunter Renfrow are back.

Green Bay Packers @ Miami Dolphins (Christmas - 1 p.m. ET)

Packers +4.5 (-110) @ Dolphins -4.5 (-110)

The NFL’s Christmas Day triple-header kicks off with an intriguing matchup between Aaron Rodgers‘ Packers and Tua Tagovailoa‘s Dolphins.

Miami feels like the play in this spot, especially given the home field and a lengthy rest advantage, but I’m wary of a Green Bay backdoor cover.

Denver Broncos @ Los Angeles Rams (Christmas - 4:30 p.m. ET)

Broncos -1 (-110) @ Rams +1 (-110)

The NFL had good intentions with this Christmas Day matchup, but things just haven’t gone to plan for either team this season. We’ll see if Russell Wilson and Baker Mayfield can make this game watchable.

I’d lean toward Denver, but this is a background noise game at best.

Tampa Bay Buccaneers @ Arizona Cardinals (Christmas - Sunday Night Football)

Buccaneers -4.5 (-110) @ Cardinals +4.5 (-110)

The NFL’s Christmas nightcap has also lost some of its luster with Kyler Murray (knee) missing the rest of the season for the Cardinals. Tom Brady and the Buccaneers are desperate for a win and might be gifted one here against Arizona third-string quarterback Trace McSorely.

I would feel comfortable laying the points with Tampa Bay if Colt McCoy (concussion) doesn’t recover in time to play.

Los Angeles Chargers @ Indianapolis Colts (Monday Night Football)

Chargers -3.5 (-110) @ Colts +3.5 (-110)

Justin Herbert and the Chargers will visit Matt Ryan and the Colts in a Boxing Day showdown at Lucas Oil Stadium. Los Angeles has won back-to-back games to vault into the playoff places, while Indianapolis just suffered one of the worst losses in NFL history.

In an already lost season, it wouldn’t surprise me if the Colts roll over here, especially without Jonathan Taylor (ankle).


John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

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