NFL Week 15 Odds | Opening NFL Moneyline, Spread, & Total Betting Lines

Posted: Aug 12, 2022Last updated: Aug 31, 2022

What’s better than football in mid-December? The answer is absolutely nothing. It’s typically the start of the fantasy football playoffs and in the actual NFL, teams start to make their late-season playoff pushes.

There are a bunch of fantastic games on the slate for this week, but are there any games you should consider wagering on now before the season actually kicks off? And what are some of our favorite picks?

Here are the current Week 15 NFL odds and lines for the 2022 season.

Week 15 NFL Odds & Lines

Week 15 NFL odds are courtesy of Betway Sportsbook unless otherwise noted and are current as of Friday, Aug. 12 at 4 p.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 15.

Week 15 NFL Games

San Francisco 49ers @ Seattle Seahawks (Thursday Night Football)

49ers -3 (-110) @ Seahawks +3 (-110)

The 49ers and Seahawks have had some awesome games in primetime over the last decade, but this doesn’t feel like it’s going to be of that same caliber. Who knows who will be starting at quarterback at this time in the year for the Seahawks and if they will even be close to playoff contention?

Take the 49ers -3 and run as this line could easily move to 6.5 or 7 before kickoff.

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Pittsburgh Steelers @ Carolina Panthers (Dec. 18, 1 p.m. ET)

Steelers +1 (-110) @ Panthers -1 (-110)

Baker Mayfield against the Steelers once again. That’s been a tough matchup for the former No. 1 pick over the last few years. Don’t expect the results to be much different here as Pittsburgh should have one of the best defenses in the NFL.

Take the Steelers here as a slight road underdog and expect them to win by at least a field goal against a much lesser team.

Philadelphia Eagles @ Chicago Bears

Eagles -4.5 (-110) @ Bears +4.5 (-110)

Justin Fields was dynamic in the preseason, and there is a lot to be excited about in Chicago. However, this is a terrible matchup for the Bears.

Philadelphia has one of the best pass rushes in the league and should be able to create pressure all day. On the other side of the ball, the Eagles shouldn’t have a problem controlling the line of scrimmage with their run game.

Take the Eagles here at -4.5 and expect them to win by double digits in Chicago.

Kansas City Chiefs @ Houston Texans

Chiefs -10 (-110) @ Texans +10 (-110)

This very easily could be a battle between the No. 1 team in the NFL and the No. 32 team.

The Chiefs are used to being double-digit road favorites, but they’ve had some trouble covering in these games over the last few years. While it seems safe to just blindly back Patrick Mahomes and Andy Reid, it’s best just to stay away from big lines like this.

Dallas Cowboys @ Jacksonville Jaguars

Cowboys -3.5 (-110) @ Jaguars +3.5 (-110)

The Cowboys are the better team on paper entering the season, but we know that doesn’t mean much. Doug Pedersen had a lot of success against the Cowboys when he was in Philadelphia, and it wouldn’t be a shock if they pulled off the upset here in Week 15.

With Jacksonville being a 3.5-point home dog, this is a good time to back them as the Cowboys have historically struggled in December. If nothing else, don’t be afraid to put the Jaguars in a teaser and move this line up to Jacksonville +10.

Detroit Lions @ New York Jets

Lions +2.5 (-110) @ Jets -2.5 (-110)

The Jets as a 2.5-point favorite in December? That seems odd. The Lions have a higher projected win total than the Jets and they play in the easier division/conference.

There is a decent chance the Lions are still in playoff contention in the NFL at this stage of the season, while the Jets could be staring at another top-10 pick in 2023. Take the Lions as a road underdog in this game and don’t be surprised if they win outright.

Miami Dolphins @ Buffalo Bills

Dolphins +6 (-110) @ Bills -6 (-110)

The Dolphins are expected to be a legitimate playoff contender this season, but this is a very tough matchup for them late in the season.

Playing in Buffalo in December can be incredibly difficult, especially when the Bills might have the best roster in the NFL. Take the Bills to win and cover here in Week 15 in this AFC East showdown.

Indianapolis Colts @ Minnesota Vikings

Colts PICK (-110) @ Vikings PICK (-110)

This is one of the toughest games of the season to pick as the Colts and Vikings are both so similar. Each team wants to have a balanced offense and they rely on superstar running backs to carry the rock.

The pick here is the Vikings at home, but this game is truly a coin flip. The best strategy here might be to wait and see how the line moves and shifts as the season goes on.

Atlanta Falcons @ New Orleans Saints

Falcons +7 (-110) @ Saints -7 (-110)

This matchup just doesn’t favor the Falcons in any way. The Saints have dominated the Falcons in New Orleans and the rosters couldn’t be further apart.

Look for the defense of the Saints to dominate in this game, allowing New Orleans to win by double digits. Take the Saints -7 with confidence in this matchup.

New York Giants @ Washington Commanders

Giants +3.5 (-110) @ Commanders -3.5 (-110)

An NFC East match-up between the Giants and the Commanders just doesn’t move the needle much. However, there is some value on the Giants here as they are a 3.5-point underdog.

It’s probably unwise to make this bet now, but keep an eye on this line as it could shift a ton over the next few months.

Baltimore Ravens @ Cleveland Browns

Ravens  @ Browns

There is no line on this game right now due to the Deshaun Watson suspension. It’s clear that sportsbooks want to see what the Browns look like this season before setting any line.

Arizona Cardinals @ Denver Broncos (Dec. 18, 4:05 p.m. ET)

Cardinals +4 (-110) @ Broncos -4 (-110)

Two of the most difficult teams to figure out for the 2022 season are the Cardinals and the Broncos. Arizona made the playoffs last season, but how has their roster improved since their playoff loss over the Rams?

For the Broncos, just how much of a difference will Russell Wilson make, and can they become a playoff contender in the wild AFC West?

In this contest, take the Broncos to win and cover the spread as the Cardinals have proven they can’t be trusted in December under Kliff Kingsbury.

Tennessee Titans @ Los Angeles Chargers

Titans +5 (-110) @ Chargers -5 (-110) 

The Titans were the No. 1 seed in the AFC last season because they were able to defeat a lot of the top teams in the conference. If they want to make it back to the playoffs this year, they are going to have to do the same thing again.

However, the Chargers are just the more talented team and this game is in Los Angeles. For that reason, bet on Justin Herbert and the Chargers to cover this 5-point spread.

Cincinnati Bengals @ Tampa Bay Buccaneers

Bengals +3 (-110) @ Buccaneers -3 (-110) 

Could this be a potential Super Bowl matchup? The Bengals have an even better roster heading into the 2022 season and should be among the favorites in the conference.

Meanwhile, this appears to be the last run for Tom Brady and the Buccaneers. This should be a highly competitive game, but take the Buccaneers and their experience here in Tampa Bay.

New England Patriots @ Las Vegas Raiders (Sunday Night Football)

Patriots +3 (-110) @ Raiders -3 (-110) 

The showcase game on Sunday Night Football will feature Bill Belichick vs Josh McDaniels. Most of the former coordinators of the Patriots don’t have a lot of success against Belichick, but the Raiders have a much better roster entering this game.

Take the Raiders to win and cover the three-point spread in this game as their offense should be able to score 24-plus points. Make Las Vegas your NFL pick of the day.

Los Angeles Rams @ Green Bay Packers (Monday Night Football)

Rams PICK (-110) @ Packers PICK (-110)

What a way to end Week 15. The Rams and Packers on Monday Night Football in the middle of December is just plain awesome.

The Packers dominated this matchup last season and they do match up well against the offense for the Rams.

Take Green Bay to win outright in this heavyweight NFC battle.


Marcus Mosher

Marcus Mosher is an NFL analyst at The Game Day, residing in Erie, PA. He covers the NFL from a betting and fantasy perspective, producing written and video content. Marcus currently hosts multiple football-related podcasts and is a managing editor at USA Today’s Sports Media Group covering the Las Vegas Raiders. He has previously worked at The Athletic and Bleacher Report.

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