NFL Week 15 Odds & Opening Lines

Last Updated: Dec 19, 2022

We’ve officially made it to the final month of the NFL regular season.

And now that the college football regular season is complete, all eyes turn to the NFL, even on Saturdays. Week 15 offers up a Saturday triple-header as part of its full 16-game slate, which will be the norm the rest of the way as all 32 teams have now completed their bye week.

This week also represents the start of the fantasy football playoffs for most leagues, so good luck to those of you that will be sweating out fantasy matchups as well as NFL bets this weekend.

Here are the current Week 15 NFL odds and lines for the 2022 season.

Week 15 NFL Odds & Lines

Week 15 NFL odds are courtesy of Caesars Sportsbook unless otherwise noted and are current as of Monday, Dec. 12, at 11 a.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 15.

Week 15 NFL Games

San Francisco 49ers @ Seattle Seahawks (Thursday Night Football)

49ers -3.5 (-110) @ Seahawks +3.5 (-110)

This line moved 2.5 points in San Francisco’s favor over the weekend after Niners quarterback Brock Purdy (3 total TDs) and this dominant defense impressed once again in a 35-7 win over Tampa Bay.

Meanwhile, Seattle fell at home to Carolina, creating a good bit of value on the home team in a bounce-back spot Thursday night.

Indianapolis Colts @ Minnesota Vikings (Dec. 17, 1 p.m. ET)

Colts +4 (-110) @ Vikings -4 (-110)

The Vikings can wrap up the NFC North title with a home victory over the Colts on Saturday. Minnesota stumbled in Detroit last week, but the Lions have been a team on the rise of late.

The same can’t really be said about an Indianapolis squad that was shellacked by the Cowboys before its bye week. I think the Vikings will bounce back, but I’m not sure I’d lay more than three points.

Baltimore Ravens @ Cleveland Browns (Dec. 17, 4:30 p.m. ET)

Ravens +2.5 (-105) @ Browns -2.5 (-115)

This AFC North showdown sees the Ravens as road underdogs in Cleveland, which makes a lot of sense since we don’t know who will be starting at quarterback for Baltimore.

Already down Lamar Jackson, the Ravens lost Tyler Huntley to a concussion in Sunday’s win over the Steelers. If third-stringer Anthony Brown is forced to start, Cleveland is the play, regardless of how rusty Deshaun Watson has looked.

Make the Browns your NFL pick of the day.

Miami Dolphins @ Buffalo Bills (Dec. 17, 8:15 p.m. ET)

Dolphins +7.5 (-110) @ Bills -7.5 (-110)

Tua Tagovailoa played his worst game of the season on Sunday night, completing 10-of-28 passes for 145 yards and a touchdown in a 23-17 loss to the Chargers. It’s hard to see him improving dramatically against a tough Bills defense in snowy Buffalo.

I’d prefer to play this as part of a teaser, but it’s Bills or nothing for me.

Pittsburgh Steelers @ Carolina Panthers (Dec. 18, 1 p.m. ET)

Steelers +2.5 (-110) @ Panthers -2.5 (-110)

Pittsburgh would be an interesting teaser partner if we knew who was starting at quarterback for the Steelers. Rookie Kenny Pickett is in concussion protocol and Mitch Trubisky tossed three interceptions in Sunday’s loss to the Ravens. There’s a chance we could see third-stringer Mason Rudolph on Sunday.

That’s not particularly encouraging, especially against a Carolina team that has won back-to-back games and could pretty easily follow Baltimore’s formula — run the ball effectively and play good defense — from this past weekend.

I’d stay away until we know more.

Philadelphia Eagles @ Chicago Bears

Eagles -9 (-110) @ Bears +9 (-110)

Two of the most exciting dual-threat quarterbacks in the NFL will take center stage on Sunday at Soldier Field when MVP favorite Jalen Hurts and the Eagles visit Justin Fields and the Bears.

Philadelphia has won four straight games, with the last two coming by 20-plus points, so it’ll take some guts to back the Bears in this spot. I’m leaning that way, but would recommend waiting to see if this line drifts to double digits.

Kansas City Chiefs @ Houston Texans

Chiefs -14 (-110) @ Texans +14 (-110)

The Texans were one of the surprise teams of Week 14, nearly upsetting the Cowboys as 17-point underdogs in Dallas. Houston is up against it again this week with Patrick Mahomes and the Chiefs coming to town.

Kansas City has struggled to cover these big spreads, but I wouldn’t be surprised if we see the Texans turn back into the corpse of a team we saw over the last month. The smart thing to do here is stay away.

Dallas Cowboys @ Jacksonville Jaguars

Cowboys -5 (-110) @ Jaguars +5 (-110)

This feels like a buy-low, sell-high spot after Dallas underperformed last week against Houston and Jacksonville routed the Titans in Tennessee.

As good as Trevor Lawrence looked last week, he has struggled against pressure and he should face a lot more of that this week. If the Cowboys clean up the turnovers, they should be able to win this game and cover.

Detroit Lions @ New York Jets

Lions PICK (-110) @ Jets PICK (-110)

Who would have foreseen the Lions and Jets playing a meaningful game against each other in December?

Detroit has won five of six to claw back into playoff picture, while New York has dropped two straight and fallen out of the AFC wild card places. The Lions have struggled away from home, so as long as Mike White is healthy enough to play, I’d lean towards the Jets at home.

Atlanta Falcons @ New Orleans Saints

Falcons +4 (-110) @ Saints -4 (-110)

It’s pretty amazing that the 4-9 Saints and 5-8 Falcons still have a realistic path to the playoffs, but that’s just how bad the NFC South has been this season.

Coming out of the bye week, Atlanta has finally decided to see if rookie quarterback Desmond Ridder can spark this inept passing attack. I think there’s value in the Cincinnati product’s upside here, so I’d lean towards backing the Falcons.

Arizona Cardinals @ Denver Broncos (Dec. 18, 4:05 p.m. ET)

Cardinals PICK (-110) @ Broncos PICK (-110)

These are two teams I don’t have much interest in watching, let alone backing with my hard-earned dollars.

Denver did show some fight last week against the Chiefs, but Russell Wilson‘s status is up in the air after leaving the game with a head injury. And while Arizona has been a solid road team, I’d rather just not watch this game.

Tennessee Titans @ Los Angeles Chargers

Titans +3 (-110) @ Chargers -3 (-110)

The Titans are reeling on the back of three straight losses, while the Chargers looked like the Super Bowl contender many expected at the start of the season in Sunday night’s win over the Dolphins.

Justin Herbert should be able to tear apart this Tennessee secondary, but the Chargers defense could have some trouble slowing down Derrick Henry. Unless the Titans get some key defensive pieces back, I like Over 46 more than either side.

Cincinnati Bengals @ Tampa Bay Buccaneers

Bengals -3.5 (-110) @ Buccaneers +3.5 (-110)

The Buccaneers looked lifeless on Sunday against the 49ers, and it’s pretty obvious that this team isn’t a Super Bowl contender. Meanwhile, the Bengals continue to look the part after dispatching the Browns without much trouble.

It’s hard to back Tampa Bay here, but I’d lean that way with three and the hook.

New England Patriots @ Las Vegas Raiders

Patriots PICK (-110) @ Raiders PICK (-110)

Originally scheduled for Sunday night, this contests pits Bill Belichick against his former offensive coordinator Josh McDaniels.

While it’s hard to bet against Belichick in that matchup, the Raiders have a sizable rest advantage and should be plenty motivated after an embarrassing TNF loss to the Rams. I’d lean towards Las Vegas, but I’d wait to see how New England looks on Monday Night Football.

New York Giants @ Washington Commanders (Sunday Night Football)

Giants +4.5 (-110) @ Commanders -4.5 (-110)

These two teams tied in Week 13, a result that is helping both stay above the Seahawks in the NFC playoff picture at the moment. However, this game will go a long way to determining those final wild card spots come season’s end.

New York just got pummeled at home by Philadelphia, while Washington is coming off its bye. I trust Taylor Heinicke and co. to get the job done at home, but this could very likely be decided by a field goal or less.

Los Angeles Rams @ Green Bay Packers (Monday Night Football)

Rams +7.5 (-110) @ Packers -7.5 (-110)

This line feels a bit disrespectful to Baker Mayfield and the Rams, who pulled off an improbable comeback to knock off the Raiders 17-16 last Thursday.

However, Green Bay is coming off its bye and Aaron Rodgers is usually a sure thing at Lambeau in December. I’d probably prefer to tease the Packers down instead of laying the points.


John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

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