NFL Week 13 Odds & Opening Lines

Last Updated: Dec 30, 2022

Week 13 brings us into December, which means the NFL playoff push is officially here.

This 15-game slate is filled with postseason implications, including a pair of tantalizing AFC playoff rematches from last January.

If that’s not enough to get you excited, we’ve also got six divisional games on the docket and the much-anticipated return of Deshaun Watson, who will face his former team, the Texans, in his Browns regular-season debut.

Here are the current Week 13 NFL odds and lines for the 2022 season.

Week 13 NFL Odds & Lines

Week 13 NFL odds are courtesy of Caesars Sportsbook unless otherwise noted and are current as of Monday, Nov. 28, at 10:30 a.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 13.

Week 13 NFL Games

Buffalo Bills @ New England Patriots (Thursday Night Football)

Bills -5.5 (-110) @ Patriots +5.5 (-110)

The Patriots have waited a long time for the chance to avenge their embarrassing 47-17 playoff loss in Buffalo last January, but that opportunity finally arrives Thursday night in Foxborough.

Bill Belichick will need a strong performance out of his defense, which struggled against Minnesota on Thanksgiving and failed to force a single punt in that postseason encounter with the Bills.

While Josh Allen hasn’t looked fully healthy, I think he’ll do enough to help Buffalo to a sizable, and significant, road victory.

Pittsburgh Steelers @ Atlanta Falcons (Dec. 4, 1 p.m. ET)

Steelers +1.5 (-110) @ Falcons -1.5 (-110)

The Steelers play on Monday night, so Atlanta will have additional rest and home-field advantages in this matchup. Still, Pittsburgh should match up pretty well against the Falcons, as its run defense is one of the best in the league.

This is a pure toss-up, and I don’t really trust either team.

Denver Broncos @ Baltimore Ravens

Broncos +8 (-110) @ Ravens -8 (-110)

The preseason lookahead line made the Ravens 1.5-point home favorites in this matchup, but this spread has ballooned as the Broncos continue to underdeliver.

Still, Baltimore’s offense hasn’t been particularly effective of late and this is a sizable margin they’ll have to clear. I’d prefer to take the Under 38.5 before backing either side since it’s very possible this game ends 13-7.

Green Bay Packers @ Chicago Bears

Packers -2 (-110) @ Bears +2 (-110)

Aaron Rodgers traditionally owns the Bears, but after the Packers’ star quarterback exited their MNF loss to the Eagles, there’s a chance this NFC North showdown features Jordan Love and Trevor Siemian.

With Justin Fields (shoulder) also not officially ruled out yet, it’s hard to make much of a determination on this game Monday morning.

Jacksonville Jaguars @ Detroit Lions

Jaguars +1.5 (-110) @ Lions -1.5 (-110)

I think this is a good buy-low spot on the Lions, who have played some solid football over the past month. Detroit has a rest advantage after playing on Thanksgiving and gave the Bills a run for their money in their annual primetime showcase.

Meanwhile, Jacksonville is coming off an emotional win against the Ravens. While Trevor Lawrence looked good, this defense has plenty of holes that the Lions can exploit.

Give me Detroit in a shootout.

New York Jets @ Minnesota Vikings

Jets +3 (-110) @ Vikings -3 (-110)

Mike White gives the Jets a capable quarterback, which has in turn earned New York some respect in the betting market. This number should probably be larger, but I wouldn’t be surprised if Kirk Cousins encounters some trouble against this elite Jets defense.

I’d look to buy Minnesota later in the week if this drops below three, but for now, I’ll pass.

Washington Commanders @ New York Giants

Commanders -1.5 (-110) @ Giants +1.5 (-110)

Who would have seen this line coming a month or so ago?

The Commanders are now road favorites over the Giants in a showdown of surprising seven-win teams. Brian Daboll has New York playing hard despite its lengthy injury list, but I’d lean toward this red-hot Washington team in this spot.

Tennessee Titans @ Philadelphia Eagles

Titans +5.5 (-110) @ Eagles -5.5 (-110)

The Eagles’ offense put on a show Sunday night against the Packers, but this Titans’ squad also recently went to Green Bay and won by a bigger margin.

I’m not sure Philadelphia will be able to slow down Derrick Henry, so I’m much more inclined to take the points with Tennessee. However, I’ll wait to see if a six pops.

Cleveland Browns @ Houston Texans

Browns -7 (-110) @ Texans +7 (-110)

The Texans have lost six straight games by seven or more points, but you would think they would be able to get up for this showdown against Deshaun Watson and the visiting Browns.

And while the atmosphere will likely be raucous, it’s not like Houston has played much competent football lately. With Watson coming off a long layoff, I’d lean toward the home team, but it’s hard to back Kyle Allen or Davis Mills.

This feels like a situation where the Texans either win outright or lose by 20.

Seattle Seahawks @ Los Angeles Rams (Dec. 4, 4:05 p.m. ET)

Seahawks -5 (-110) @ Rams +5 (-110)

After a heartbreaking overtime loss to the Raiders last week, the Seahawks desperately need a victory to stay in the NFC playoff race. Pete Carroll will be happy to see the depleted Rams next up on the schedule, especially since Los Angeles can’t really run the football.

Seattle should get back on track here.

Miami Dolphins @ San Francisco 49ers

Dolphins +3.5 (-110) @ 49ers -3.5 (-110)

Dolphins coach Mike McDaniel will square off with his mentor Kyle Shanahan in what should be one of the marquee games of the weekend. Both teams enter on lengthy winning streaks, though Miami hasn’t exactly beaten a quality opponent since September.

This will be a big test, one that I think Tua Tagovailoa could struggle in. Still, I can’t lay three and the hook with San Francisco.

Kansas City Chiefs @ Cincinnati Bengals

Chiefs -2.5 (-110) @ Bengals +2.5 (-110)

The Chiefs visit Cincinnati in an AFC Championship Game rematch, one that the Bengals won to advance to the Super Bowl. In fact, Joe Burrow got the better of Patrick Mahomes twice last season, though those wins came by a combined six points.

With the spread sitting at less than three, I feel pretty good about Kansas City getting its revenge here. Back the Chiefs as your NFL pick of the day.

Los Angeles Chargers @ Las Vegas Raiders

Chargers -2.5 (-110) @ Raiders +2.5 (-110)

The Week 18 showdown between these two AFC West rivals last year wasn’t technically a playoff game, but it felt like one. Daniel Carlson‘s walk-off field goal simultaneously sent the Raiders to the postseason and the Chargers home in one of the wildest regular-season games in recent memory.

While LA will be hoping for a different result Sunday, I think they’ll have some trouble containing Josh Jacobs. This should be another close contest that could go either way.

Indianapolis Colts @ Dallas Cowboys (Sunday Night Football)

Colts +9.5 (-110) @ Cowboys -9.5 (-110)

This is a good situational spot to back Dallas, especially given the rest differential after the Cowboys won on Thanksgiving and Indianapolis didn’t feature in Week 12 until Monday night.

I would probably wait for this line to come down, though, as bettors could be less interested in betting another big Dallas number after the Giants got in the back door late last week.

New Orleans Saints @ Tampa Bay Buccaneers (Monday Night Football)

Saints +4.5 (-110) @ Buccaneers -4.5 (-110)

Does anyone have any idea how to handicap the teams in the NFC South? Seriously, seemingly every team in the division is mediocre, and Tom Brady has struggled mightily against the Saints since moving to Tampa.

This number in a dead zone doesn’t do much for me, but I’d lean toward New Orleans in a game that shockingly has postseason implications for both teams.


John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

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