NFL Week 13 Odds | Opening NFL Moneyline, Spread, & Total Betting Lines

Posted: Aug 12, 2022Last updated: Aug 31, 2022

The slate of games is absolutely loaded. There is no other way to describe it.

Week 13 of the NFL season delivers enormous divisional games, massive playoff rematches, and more. The Sunday afternoon matchup between the Chiefs and the Bengals is the main event, although this weekend has depth. And at this point in the calendar, with the season winding down, the stakes will be enormous.

Here are the current Week 13 NFL odds and lines for the 2022 season.

Week 13 NFL Odds & Lines

Week 13 NFL odds are courtesy of Betway Sportsbook unless otherwise noted and are current as of Friday, Aug. 12 at 4 p.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 13.

Week 13 NFL Games

Buffalo Bills @ New England Patriots (Thursday Night Football)

Bills -3 (-110) @ Patriots +3 (-110)

Amazon will provide us with an AFC East tussle between two teams that also met in the playoffs last year. Buffalo did not punt a single time against the Pats in its playoff opener, which tells you everything you need to know. The score, 47-17, tells you even more.

This will mark the first time these two teams meet this season - the second will be in Week 18. While I don’t expect that playoff game to repeat itself, getting Buffalo as a field goal favorite feels like a steal.

Sportsbook Play of the Day

Before you make your next NFL Week 13 bet, you should know that Caesars Sportsbook is among the industry’s best, offering tons of promotions.

Go Full Caesar this season and get your first bet on Caesars up to $1,250, plus 1,000 Tier Credits and 1,000 Reward Credits with the promo code .

Read Chris Wassel’s Caesars Sportsbook review for more insight and get your welcome bonus below, or continue reading this NFL Week 13 analysis.

Pittsburgh Steelers @ Atlanta Falcons (Dec. 4, 1 p.m. ET)

Steelers -2.5 (-110) @ Falcons +2.5 (-110)

The most interesting element of this matchup for the Steelers is actually the stretch of games that comes before. Pittsburgh plays New Orleans, Cincinnati, and Indianapolis on Monday night before heading to Atlanta on a short week.

Although Pittsburgh does feel like the better overall team, this brutal stretch is worth considering. I’ll back the Falcons and Marcus Mariota at home.

Denver Broncos @ Baltimore Ravens

Broncos +1.5 (-110) @ Ravens -1.5 (-110)

If Russell Wilson plays up to his standard, which this point spread implies he will, this will be fascinating. Lamar Jackson as a quarterback counter, however, is plenty good.

While there is plenty of untapped potential with the Broncos, it feels like this line is assuming all of it will be crystalized on the road. I’m just not there, at least not yet, and I’ll gladly back the home team as a small chalk.

Green Bay Packers @ Chicago Bears

Packers -4 (-115) @ Bears +4 (-105)

If you have followed this rivalry closely or even from a distance, you know the drill. Aaron Rodgers owns the Bears, which is something he actually said out loud last year.

The two teams will meet in Green Bay early in the season, and this will mark the second matchup. Although I have concerns about how Green Bay’s wideouts will fill the void of Davante Adams, I have more concerns about the Bears’ offense. I’ll gladly lay the points. Beat me if you can, Bears.

Jacksonville Jaguars @ Detroit Lions

Jaguars +2 (-110) @ Lions -2 (-110)

This is not a sexy football game. Let’s get that out of the way right now. But while the reboots for both teams remain a work in progress, there are some elements of hope here.

Those elements actually make this a tough game to bet. For me, however, I am willing to bet on Trevor Lawrence taking the next step. I’m taking the dog.

New York Jets @ Minnesota Vikings

Jets +4.5 (-110) @ Vikings -4.5 (-110)

This just doesn’t seem like a great spot for the Jets on a handful of fronts. Although New York plays the Bears at home the week prior, the road trip comes the week before a trip to Buffalo and after two games against the Patriots and another against the Bills.


A healthy Carl Lawson should go a long way in slowing down the Vikings’ offense, but it won’t be enough. Minnesota it is.

Washington Commanders @ New York Giants

Commanders PICK (-110) @ Giants PICK (-110)

Given the unknowns surrounding both teams and their starting quarterbacks, this is a tough one to figure out. Daniel Jones vs Carston Wentz feels a little like football roulette.

Here’s what we know: Washington won both matchups last season, including a dominating road win over the Giants in Week 18. At this point, however, there’s a stronger case to be made for Jones along with a healthy Saquon Barkley at running back. Home team lean.

Tennessee Titans @ Philadelphia Eagles

Titans +2 (-110) @ Eagles -2 (-110)

The Titans play at Kansas City, vs. Denver, at Green Bay, and against the Bengals before this road game, which is a noteworthy stretch of games. It also makes me inclined to back the home team.

Jalen Hurts has weapons, and Philadelphia could certainly benefit from those in a game like this. The explosiveness (and home field) is on the Eagles’ side.

Cleveland Browns @ Houston Texans

Browns N/A @ Texans N/A

Well, we don’t need to state the obvious. Deshaun Watson will take on his former team, and it is poised to be a range of emotions for all parties involved.

The fact that he’s playing in Houston only adds to the intrigue. The line in this game, by the time we arrive there, is likely to be much smaller than many expect. This one is complicated.

Seattle Seahawks @ Los Angeles Rams (Dec. 4, 4:05 p.m. ET)

Seahawks +9.5 (-110) @ Rams -9.5 (-110)

Geno Smith is the starter in Seattle, but for how long? The answer might not impact this game one way or another. For me, it won’t. A road game against the Super Bowl champs, despite the huge line, isn’t enough to sway me from the favorite.

The Rams will be long clear of the Super Bowl hangover by this point. It’s a big number, but I am still willing to lay it.

Miami Dolphins @ San Francisco 49ers

Dolphins +3.5 (-110) @ 49ers -3.5 (-110) 

In a loaded week of games, Dolphins vs 49ers might take a backseat. It probably shouldn’t be forgotten given the talent levels top to bottom on the roster, but it might be lost some.

For all of the conversations regarding Tua Tagovailoa, Trey Lance has just been so-so thus far.

Kansas City Chiefs @ Cincinnati Bengals

Chiefs PICK (-110) @ Bengals PICK (-110) 

The game of the week is one of the most compelling games of the year. It’s also a game we saw twice in 2021, with the Bengals winning both games by a combined six points.

This offseason, however, only one team got noticeably better. While KC lost its best deep threat, Cincinnati added more talent, especially across the offensive line, to help its young quarterback. There’s no reason to believe this result will be any different.

Back the Bengals as your NFL pick of the day.

Los Angeles Chargers @ Las Vegas Raiders

Chargers PICK (-110) @ Raiders PICK (-110)

It was a tale of two games for these two teams last year. The Chargers won the first matchup without issue, and the Raiders won the finale to make the playoffs in a somewhat thrilling fashion.

Given the additions of both, this game takes on new life. They will meet in Week 1 and then here, which will be far more significant given its time in the calendar. It’s a tough one for me to make, although I’ll take the Chargers to win.

Indianapolis Colts @ Dallas Cowboys (Sunday Night Football)

Colts +2.5 (-110) @ Cowboys -2.5 (-110)

This is the kind of game where the loss of lineman Tyron Smith really hurts for the Cowboys. For Indianapolis, it will try to play ball control and run Jonathan Taylor early and often.

With the addition of Matt Ryan, Indy really does feel like it has the upper hand. I am feeling a (slight) Cowboys regression. Give me the 2.5.

New Orleans Saints @ Tampa Bay Buccaneers (Monday Night Football)

Saints +6.5 (-110) @ Buccaneers -6.5 (-110)

The Saints have largely had Tom Brady‘s number since he arrived in Tampa Bay, although playing on the road on Monday night is going to present some challenges.

The particular matchup in this game that feels like an issue is the Bucs’ o-line vs. the Saints’ very active front. Injuries have really put Tampa Bay in a compromised spot, and I will gladly take the points as a result.


Adam Kramer

Adam Kramer is an NFL, college football, and gambling analyst for The Game Day. While college football has long been his calling, he’s also covered sports such as boxing, horse racing, and baseball at The Game Day and in other places. He’s also written for Bleacher Report, VSiN, and various other outlets over the past decade-plus.

Related articles