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NFL Week 12 Odds | Opening NFL Moneyline, Spread, & Total Betting Lines

Posted: Aug 12, 2022Last updated: Aug 31, 2022

There is nothing like football and Thanksgiving.

The two go together brilliantly, and the combination of turkey and pigskin complement each other incredibly well.

Week 12 of the NFL season features three Thanksgiving Day games. It also delivers a matchup between the Rams and the Chiefs - two teams with Super Bowl aspirations and familiarity. Oh, and there is more.

Here are the current Week 12 NFL odds and lines for the 2022 season.

Week 12 NFL Odds & Lines

Week 12 NFL odds are courtesy of Betway Sportsbook unless otherwise noted and are current as of Friday, Aug. 12 at 4 p.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 12.

Week 12 NFL Games

Buffalo Bills @ Detroit Lions (Thanksgiving - 12:30 p.m. ET)

Bills -8 (-110) @ Lions +8 (-110)

The early Thanksgiving game feels like a sizable mismatch. Given Josh Allen‘s meteoric rise in Buffalo, it just doesn’t feel like Detroit is equipped to handle that.

The good news for the Lions is that they will play at home, per tradition. They also have enough promising young players to provide some hope for the future. For me, however, it’s not enough. I’ll gladly take eight points now, because I don’t anticipate this line getting any smaller.

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New York Giants @ Dallas Cowboys (Thanksgiving - 4:30 p.m. ET)

Giants +7 (-120) @ Cowboys -7 (+100)

The Cowboys will assume their normal position in Thanksgiving’s second game, and the opponent will be awfully familiar.

This matchup last year was not kind to New York. Dallas won and covered the spread in both games. The Giants are hoping to protect Daniel Jones better than they did, and they will need to do just that to cover this spread. Given the Dallas pass rush, however, I have my doubts. Another chalky (but profitable) Thanksgiving Day pick.

New England Patriots @ Minnesota Vikings (Thanksgiving - 8:20 p.m. ET)

Patriots +1.5 (-110) @ Vikings -1.5 (-110)

The nightcap on Thanksgiving will feature two playoff hopefuls trying to figure out if they’re on the rise or beginning to fall. New England quarterback Mac Jones is likely to swing this point spread one way or another. The bigger question is whether he will have the appropriate help.

The Vikings struggled in close games for much of the year, although they were also competitive with good teams. I have enough questions about New England to back the home team in this one.

Denver Broncos @ Carolina Panthers (Nov. 27, 1 p.m. ET)

Broncos -2.5 (-110) @ Panthers +2.5 (-110)

The new-look Broncos will take the show on the road against the Panthers, which is a cross-country trip and a trickier spot than most expect.

Looking at the point spread, however, tells a different story. Russell Wilson is likely to have a huge impact on the season, although the Baker Mayfield-led Panthers are getting plenty of respect from the oddsmakers. I could see it, and I’ll gladly take the points at home.

Baltimore Ravens @ Jacksonville Jaguars

Ravens -4 (-110) @ Jaguars +4 (-110)

Just how much better will the Jaguars be? If this point spread holds, the answer is considerably.

Considering that Jacksonville beat both Buffalo and Indianapolis at home last year, it’s reasonable to expect a roster that has been infused with young talent and capable vets to improve. Taking the four points here really is a bet on quarterback Trevor Lawrence to grow and develop, and that’s precisely what I plan to do.

Houston Texans @ Miami Dolphins

Texans +7 (-110) @ Dolphins -7 (-110)

Tyreek Hill vs Derek Stingley is going to be a doozy of a matchup on the outside, although that’s going to be a tough cover for a rookie cornerback. The bigger concern for Houston, however, is scoring points on the road.

Even if you have concerns about Dolphins’ quarterback Tua Tagovailoa, you have to love only laying a touchdown here.

Chicago Bears @ New York Jets

Bears +2.5 (-110) @ Jets -2.5 (-110)

At this point in the season, we’ll know if the mounting optimism surrounding both of these teams is real. Although Bears quarterback Justin Fields could make this interesting, Zach Wilson, assuming he’s healthy, will have the better supporting cast.

This is more about what is being put around these pieces. Throw in home field, and we’re riding with the Jets.

Cincinnati Bengals @ Tennessee Titans

Bengals PICK (-110) @ Titans PICK (-110)

The Super Bowl runner-ups will hit the road to take on the Titans in a fascinating, pivotal AFC game. The Bengals will likely be a popular choice this week and every week, but Derrick Henry could be an interesting counter.

We’re sleeping on the Titans, and they will likely be larger favorites by the time this one rolls around. I like them to win here, which is all you need.

Atlanta Falcons @ Washington Commanders

Falcons +5 (-110) @ Commanders -5 (-110)

Although your attention will likely be elsewhere in the slate, Washington and Atlanta will play a football game. At this point of the year, we will know plenty more about Commanders’ quarterback Carson Wentz. And although Atlanta has some flashier weapons, headlined by Kyle Pitts, Washington is the more complete team.

That might not be saying much, but I am laying the points.

Tampa Bay Buccaneers @ Cleveland Browns

Buccaneers N/A @ Browns N/A

We will assume that the quarterbacks for this game will be Tom Brady and Deshaun Watson. Given Brady’s training camp absence and Watson’s winding road, nothing should be assumed at this point.

Assuming both suit up, we could see a version of the Browns we haven’t seen. At home, Cleveland could be a tough, cold spot for the Bucs.

Los Angeles Chargers @ Arizona Cardinals (Nov. 27, 4:05 p.m. ET)

Chargers -1.5 (-110) @ Cardinals +1.5 (-110)

The Chargers will have the task of slowing down Kyler Murray, which should be a fascinating football chess match. For Arizona, one can’t help but wonder if the second-half struggles show up in a game like this.

Whether they do or not, the Chargers feel a cut above at many positions. I’ll lay the points with the road favorite.

Las Vegas Raiders @ Seattle Seahawks

Raiders -2 (-110) @ Seahawks +2 (-110) 

Let’s dive right into it. This feels like tremendous value with the Raiders.

Yes, Seattle has a tremendous home-field advantage, but the offense has issues, no matter if it’s Geno Smith or Drew Lock playing quarterback. The fact that we’re even having that conversation says it all. Derek Carr is in line for a huge year, and this line is likely to take a big leap by the time they play.

Los Angeles Rams @ Kansas City Chiefs

Rams +2.5 (-110) @ Chiefs -2.5 (-110) 

The game of the week - and one of the games of the year - has a point spread hovering around a field goal. They were close to meeting in the Super Bowl last season, and many still believe both teams are in position to make another run.

Can Kansas City’s offensive line hold up against Aaron Donald? How will KC’s new-look offense perform against the Rams’ excellent secondary? If the points start flying, will Los Angeles be able to keep up at home?

Given the power of home field, I’ll side with the Chiefs in a really tight spot as our NFL pick of the day.

New Orleans Saints @ San Francisco 49ers

Saints +4 (-110) @ 49ers -4 (-110) 

This will be a huge test for Trey Lance, assuming he’s San Francisco’s starter at this point. The fact that I even have to say that says plenty about my reservations. The alarms aren’t sounding yet, but we’re looking out.

Even on the road, expect New Orleans’ defense to travel. And you’re giving me more than a field goal? Sign me up.

Green Bay Packers @ Philadelphia Eagles (Sunday Night Football)

Packers PICK (-110) @ Eagles PICK (-110)

The Sunday night game is an absolute banger. One team, Green Bay, said farewell to one of the league’s best wideouts. The other, Philadelphia, is hoping its new star wideout is the difference for its young quarterback and team.

While it’s always hard to bet against the Eagles at home, I’m willing to jump in early before they become a bigger favorite.

Pittsburgh Steelers @ Indianapolis Colts (Monday Night Football)

Steelers +4.5 (-110) @ Colts -4.5 (-110)

Indy will play host to the final game of the weekend, which feels like a guarantee for some quality hitting on both sides.

In terms of forecasting, however, it has to start with the quarterbacks. Matt Ryan vs Mitch Trubisky or Kenny Pickett feels like a pretty large mismatch, even as Ryan cruises toward the end of his career. This line will be a touchdown by the time they meet. I’ll take the Colts.


Adam Kramer

Adam Kramer is an NFL, college football, and gambling analyst for The Game Day. While college football has long been his calling, he’s also covered sports such as boxing, horse racing, and baseball at The Game Day and in other places. He’s also written for Bleacher Report, VSiN, and various other outlets over the past decade-plus.

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