NFL Week 10 Odds | Opening NFL Moneyline, Spread, & Total Betting Lines

Posted: Jul 12, 2022Last updated: Aug 5, 2022

Week 10 takes us into mid-November, which is when the weather truly starts becoming a factor in the NFL.

The temps in the northern half of the U.S. traditionally start to dip from the comfortable 60s to the 40s and 50s, or colder if there are night games. Most areas get their first frost, and snow isn’t out of the question, especially in the Great Lakes region.

Week 10 is also when the playoff races get hot. The stretch drive is going, and most teams are still alive, albeit barely.

It’s also a great week to be a football bettor. Here are the current Week 10 NFL odds and lines for the 2022 season.

NFL Week 10 Odds & Lines

Week 10 NFL odds are courtesy of Betway Sportsbook unless otherwise noted and are current as of Tuesday, August 2 at 2 p.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 10.

NFL Week 10 Games

Atlanta Falcons @ Carolina Panthers (Thursday Night Football)

Falcons +4.5 (+100) @ Panthers -4.5 (-120)

These teams should be familiar, considering this will be their second meeting in a span of 12 days. Laying the Panthers seems like the best option, assuming Christian McCaffrey is healthy.

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Seattle Seahawks @ Tampa Bay Buccaneers (Nov. 13, 9:30 a.m. ET - Munich)

Seahawks +9.5 (-110) @ Buccaneers -9.5 (-110)

The Bucs are loaded, and Seattle should be bad, but laying more than a touchdown on a game played in Europe is a dicey proposition. Take the points.

Minnesota Vikings @ Buffalo Bills (Nov. 13, 1 p.m. ET)

Vikings +7.5 (-110) @ Bills -7.5 (-110)

The Bills live for cold-weather home games, especially those played in November or later. They should be able to cover a touchdown and two-point conversion.

Detroit Lions @ Chicago Bears

Lions +1.5 (-110) @ Bears -1.5 (-110)

A coin-toss game and the sportsbook gives a slight edge to the Lions. We’d trust the home team.

Jacksonville Jaguars @ Kansas City Chiefs

Jaguars +10 (-110) @ Chiefs -10 (-110)

The Jaguars could be sneaky competitive in Year 2 of the Trevor Lawrence experience. They could be able to get inside double-digits, especially with a back-door cover.

Houston Texans @ New York Giants

Texans +3 (-110) @ Giants -3 (-110)

If the Giants are going to make progress under Brian Daboll, this is a game they should win and cover.

New Orleans Saints @ Pittsburgh Steelers

Saints +1.5 (-110) @ Steelers -1.5 (-110)

The Steelers usually play well at home in cold weather against unaccustomed opponents, and it’s possible they’ll have handed the reins to first-round pick Kenny Pickett by this point. But the Saints should be tough to beat.

Denver Broncos @ Tennessee Titans

Broncos PICK (-110) @ Titans PICK (-110)

The Broncos feel like a candidate for underachieving, which makes this a game/spread worth mashing.

Cleveland Browns @ Miami Dolphins

Browns -1 (+100) @ Dolphins +1 (-120)

Obviously, a lot depends on where Deshaun Watson is at in his return to play after likely missing 20 months of football, but this could be a really fun game. Or it could be Watson showcasing what the Dolphins missed out on by not acquiring him.

Indianapolis Colts @ Las Vegas Raiders (Nov. 13, 4:05 p.m. ET)

Colts +2 (-110) @ Raiders -2 (-110)

It’ll be interesting to see if quarterback Matt Ryan is still upright at this point in the season, but if he is, the duo of him and Jonathan Taylor might make this a long afternoon for Las Vegas.

Dallas Cowboys @ Green Bay Packers

Cowboys +4 (-110) @ Packers -4 (-110) 

Mike McCarthy‘s first game back at Lambeau also expects to be a clash of NFC titans that will undoubtedly be broadcast from coast-to-coast. Expect Aaron Rodgers and co. to rain on his homecoming parade.

Back Green Bay as your NFL pick of the day.

Arizona Cardinals @ Los Angeles Rams

Cardinals +6 (-110) @ Rams -6 (-110) 

Kliff Kingsbury is just 1-6 against Sean McVay in the wunderkinds’ previous seven meetings entering 2022, though that one win did come at SoFi in 2021. Lay the touchdown and trust the Rams to get the job done.

Los Angeles Chargers @ San Francisco 49ers (Sunday Night Football)

Chargers PICK (-110) @ 49ers PICK (-110)

The Chargers are a chic darkhorse to challenge for the NFC West crown. The Niners are loaded and could be a Super Bowl contender if Trey Lance is the real deal. This should be a fun one.

Washington Commanders @ Philadelphia Eagles (Monday Night Football)

Commanders +3.5 (-110) @ Eagles -3.5 (-110)

Jalen Hurts and the Eagles should be able to run all over the Commanders. Mash Philadelphia.


Pat Pickens

Pat Pickens is a seasoned sportswriter who has covered the NHL since 2013 for various websites, including The New York Times,,, USA Today, the Associated Press and many others. His debut book, titled "The Whalers" about the history of the NHL's Hartford Whalers, was released in October 2021. His greatest successful wager was an LA Kings puck-line bet (+200) in Game 1 of the 2012 Western Conference Final.

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