NFL Week 10 Odds

Frank AmmiranteSenior Sports Writer
Last Updated: Jul 25, 2023

Week 10 marks the start of the second half of the NFL regular season.

It’s highlighted by the third regular season in Germany, with the Indianapolis Colts and New England Patriots battling it out at Deutsche Bank Park in Frankfurt.

There are also other intriguing matchups, such as the Browns-Ravens and Lions-Chargers, so let’s take a closer look at the Week 10 NFL odds and lines for the 2023 season.

NFL Week 10 Odds & Lines

Week 10 lines are courtesy of DraftKings Sportsbook and current as of Tuesday, June 20, at 2 p.m. ET.

Keep tabs on all of our current NFL odds.

NFL Week 10 Games

Carolina Panthers @ Chicago Bears

Nov. 9, 8:20 p.m. ET (TNF)

  • Panthers +2 (-110) @ Bears -2 (-110)

This is an interesting matchup between the two teams who made the biggest splash in the NFL Draft, with the Panthers giving up several assets to move up to the Bears’ slot to take Bryce Young.

Bears’ quarterback Justin Fields is poised to take the next step in his development following upgrades to his supporting cast. We could see him find ex-Panther D.J. Moore early and often in this game.

Chicago is the better team here and they have home field advantage, so I’ll take the Bears -2.

Indianapolis Colts @ New England Patriots

Nov. 12, 9:30 a.m. ET (Frankfurt, Germany)

  • Colts +5 (-110) @ Patriots -5 (-110)

The Patriots project to have one of the most improved offenses in football following the hiring of Bill O’Brien at offensive coordinator, but they could be in tough against Anthony Richardson and the Colts.

Richardson landed in the perfect spot for his development, as he’ll get to work with Shane Steichen, who helped Jalen Hurts thrive in Philadelphia.

While the Patriots have the overall edge here, five points seems a bit too daunting. Give me the Colts +5 in a neutral location in Germany.

Houston Texans @ Cincinnati Bengals

Nov. 12, 1 p.m. ET

  • Texans +9.5 (-110) @ Bengals -9.5 (-110)

What a story it would be if former Ohio State star quarterback C.J. Stroud returns to the Buckeye State to go toe-to-toe with Joe Burrow in Cincinnati.

This feels like an unlikely outcome given the talent disparity between these two sides, with the Texans projected to be among the worst in the NFL, while the Bengals are Super Bowl contenders.

Look for Cincinnati to get it done at home in our NFL bet of the day.

Tennessee Titans @ Tampa Bay Buccaneers

Nov. 12, 1 p.m. ET

  • Titans -1 (-110) @ Buccaneers +1 (-110)

Here we have two former playoff contenders that project to be bottom-feeders in 2023.

I give the edge to the Titans, who have the advantage at quarterback with Ryan Tannehill over Baker Mayfield. Tennessee has also proven to perform above expectations throughout Mike Vrabel‘s tenure as head coach.

Take the Titans -1 as short road favorites here.

Cleveland Browns @ Baltimore Ravens

Nov. 12, 1 p.m. ET

  • Browns +3 (-110) @ Ravens -3 (-110)

This is a clash between two AFC North contenders, so we can expect it to come down to the wire.

The Browns should have a much more explosive passing game with a full year of Deshaun Watson, especially after they added promising young wideout Elijah Moore.

The same can be said for the Ravens under new offensive coordinator Todd Monken. I give the edge to Baltimore since they’re at home, so we’ll take the Ravens -3.

San Francisco 49ers @ Jacksonville Jaguars

Nov. 12, 1 p.m. ET

  • 49ers -1 (-110) @ Jaguars +1 (-110)

The 49ers remain as one of the most talented teams in the NFL. Brock Purdy is expected to be ready for the start of the season. This is once again going to be an exciting offense, especially if they can stay healthy.

The Jaguars could take a leap on offense with Calvin Ridley in the fold, but I’m not sure they’re good enough to hang with the Niners. The line reflects this with San Francisco coming in as short road favorites.

Let’s take the 49ers -1 here.

New Orleans Saints @ Minnesota Vikings

Nov. 12, 1 p.m. ET

  • Saints -2.5 (-110) @ Vikings -2.5 (-110)

The Saints are NFC South favorites after solidifying their quarterback with a stable veteran presence in Derek Carr, but they’re still not as good as the Vikings.

Minnesota upgraded at wideout with first-round selection Jordan Addison replacing Adam Thielen. You’re going to see their defense improve as well with Brian Flores at the helm.

Add in home field advantage and you have a perfect recipe for Vikings -2.5 here.

Green Bay Packers @ Pittsburgh Steelers

Nov. 12, 1 p.m. ET

  • Packers +3 (-110) @ Steelers -3 (-110)

It’s hard to figure out the Packers right now because new quarterback Jordan Love is a complete wildcard. While it’s not like Aaron Rodgers was that good last year, it’s still tough to see Green Bay as playoff contenders until we learn more about Love.

Meanwhile, the Steelers did a great job addressing their offensive line this season, which should help second-year signal-caller Kenny Pickett take the next step in his development.

For that reason, I’ll take the Steelers -3 at home.

Atlanta Falcons @ Arizona Cardinals

Nov. 12, 4:05 p.m. ET

  • Falcons -2.5 (-115) @ Cardinals +2.5 (-105)

The Falcons are the better team on paper, boasting a stacked offense that includes Drake London, Kyle Pitts, and Bijan Robinson.

However, it’s highly likely that Kyler Murray will be ready for this game, since it’s all the way in Week 10, giving Arizona the edge at quarterback over Desmond Ridder.

Add in the fact that the Cardinals are home dogs and you have an appealing play at +2.5.

Detroit Lions @ Los Angeles Chargers

Nov. 12, 4:05 p.m. ET

  • Lions +2.5 (+100) @ Chargers -2.5 (-120)

You could argue that this is the most exciting matchup on the slate, featuring two Super Bowl dark horses.

Jameson Williams will be back for the Lions after serving his six-game suspension, so we could see a high-scoring game here.

I give the edge to the Chargers since they’re better at quarterback with Justin Herbert over Jared Goff. It also helps that the game is in Los Angeles. I’ll take the Chargers -2.5 in this spot.

New York Giants @ Dallas Cowboys

Nov. 12, 4:25 p.m. ET

  • Giants +5.5 (-110) @ Cowboys -5.5 (-110)

The Giants overachieved a bit last year in making the playoffs, so we could see some negative regression in Year 2 under Brian Daboll.

The Cowboys brought in Brandin Cooks to give Dak Prescott another weapon, which was desperately needed in this offense.

While 5.5 points may seem like a lot, I’ll stick with Dallas since they’re the much better team on paper.

Washington Commanders @ Seattle Seahawks

Nov. 12, 4:25 p.m. ET

  • Commanders +4 (-110) @ Seahawks -4 (-110)

Here we have two teams trending in opposite directions. The Commanders are relying on first-year starter and former fifth-rounder Sam Howell at quarterback, while the Seahawks just upgraded their offense with Jaxon Smith-Njigba and Zach Charbonnet.

There’s a chance that Geno Smith is even better with these improvements. Seattle also added blue-chip first-rounder Devon Witherspoon to shore up their secondary.

Simply put, the Seahawks are the much better team here, making -4 look like a must-play.

New York Jets @ Las Vegas Raiders

Nov. 12, 8:20 p.m. ET (SNF)

  • Jets -2.5 (-110) @ Raiders +2.5 (-110)

The Jets head to Vegas to take on the Raiders under the primetime lights of Sunday Night Football.

New York has a significant edge here because they’re the better team from top to bottom. Whether it’s on offense with Aaron Rodgers and Garrett Wilson, or on defense with Sauce Gardner locking down the secondary, the Jets are superior in every aspect.

The Raiders may be one of the sneaky bad teams that we get each NFL season, making Jets -2.5 look like a strong play.

Denver Broncos @ Buffalo Bills

Nov. 13, 8:20 p.m. ET (MNF)

  • Broncos +6 (-110) @ Bills -6 (-110)

The Broncos are hoping to bounce back in Year 2 of Russell Wilson with Sean Payton now at head coach, but it’s going to be tough for them to defeat the Bills in Buffalo, especially on Monday Night Football.

The Bills are a top-three team right now, while the Broncos could struggle to make the playoffs.

Look for Josh Allen and company to win by more than a touchdown here.


Frank Ammirante

Frank Ammirante is a Senior Sports Writer at The Game Day. Previously, he wrote for 4for4 Football and RotoBaller. Frank is a member of the Fantasy Sports Writer's Association while maintaining an active presence within the community. He has competed in industry contests like the Scott Fish Bowl, The Great Fantasy Baseball Invitational, and more. Frank will be making his debut in Tout Wars this year. He's got a diverse sporting background, but specializes in football and baseball.

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