NFL Week 10 Odds & Opening Lines

Posted: Nov 7, 2022Last updated: Jan 23, 2023

With nine of 18 weeks in the books, Week 10 marks the start of the second half of the NFL regular season.

It also will feature the first ever regular-season game played in Germany, as the Seattle Seahawks and Tampa Bay Buccaneers will meet at Allianz Arena in Munich.

That matchup should tell us a lot about each team’s chances in the ever-changing NFC playoff picture, as should the week on a whole, especially since the four teams on a bye all represent the AFC (Jets, Patriots, Bengals, and Ravens).

Here are the current Week 10 NFL odds and lines for the 2022 season.

NFL Week 10 Odds & Lines

Week 10 NFL odds are courtesy of FanDuel Sportsbook unless otherwise noted and are current as of Monday, Nov. 7, at 11 a.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 10.

NFL Week 10 Games

Atlanta Falcons @ Carolina Panthers (Thursday Night Football)

Falcons -3 (-110) @ Panthers +3 (-110)

Carolina didn’t have to wait long for the opportunity to avenge its Week 8 overtime loss in Atlanta, a game it should have won after D.J. Moore hauled in a late Hail Mary from P.J. Walker.

I think taking the points with the Panthers at home on a short week makes a lot of sense, especially with a revenge narrative in play.

Seattle Seahawks @ Tampa Bay Buccaneers (Nov. 13, 9:30 a.m. ET - Munich)

Seahawks +1.5 (-108) @ Buccaneers -1.5 (-112)

The preseason lookahead line for this matchup was Buccaneers -9.5. It’s safe to say the perception of both teams has changed since then.

Still, Tom Brady got the job done in the final moments of last week’s win over the Rams, but can he and the offense finally get going in Germany? Tampa Bay will have to improve to hang with a much-improved Seahawks squad.

Minnesota Vikings @ Buffalo Bills (Nov. 13, 1 p.m. ET)

Vikings +7.5 (-115) @ Bills -7.5 (-105)

Oddsmakers might be disrespecting the 7-1 Vikings, who are underdogs of more than a touchdown heading into Buffalo.

Minnesota has a knack for playing one-score games, but I wouldn’t recommend fading the Bills after a disappointing divisional loss to the Jets.

Detroit Lions @ Chicago Bears

Lions +2.5 (-105) @ Bears -2.5 (-115)

These are two of the tougher teams to figure out on a week-to-week basis.

I understand wanting to back Justin Fields and the Bears off an impressive offensive performance, but I can’t trust either of these squads.

Jacksonville Jaguars @ Kansas City Chiefs

Jaguars +9.5 (-105) @ Chiefs -9.5 (-115)

As good as the Chiefs have been in the Patrick Mahomes era, Kansas City typically has trouble covering these large spreads at home.

Andy Reid‘s team is 0-3 ATS as a home favorite this season and none of the Jaguars’ six losses this season have come by double digits. You’ll probably be able to get Jacksonville +10 later in the week, but I’d still feel comfortable at this number.

Houston Texans @ New York Giants

Texans +6.5 (-105) @ Giants -6.5 (-115)

The Giants are 6-2 but have won just one game by seven or more points — an eight-point win over the Bears in Week 4.

While it’s tempting to back New York off a bye against one of the worst teams in the league, the Texans were competitive in their TNF loss to the Eagles and could keep this game interesting.

New Orleans Saints @ Pittsburgh Steelers

Saints -3 (-106) @ Steelers +3 (-114)

The bye week should have helped rookie Kenny Pickett make some corrections, especially in the turnover department, which could help this Steelers’ offense in a tricky matchup.

I’d take the points with Pittsburgh at home before this number creeps below three.

Denver Broncos @ Tennessee Titans

Broncos +2.5 (-110) @ Titans -2.5 (-110)

Who knows what the Broncos will look like coming off their bye week, but more importantly, we also don’t know Ryan Tannehill‘s status for Tennessee just yet. Malik Willis was ineffective as a passer in his stead on SNF, but I will probably stay away from this matchup of two teams I don’t trust.

Cleveland Browns @ Miami Dolphins

Browns +4 (-110) @ Dolphins -4 (-110)

This game should feature a massive contrast in styles, as Cleveland will rely on Nick Chubb and the rushing attack while Miami leans on the arm of Tua Tagovailoa.

The Dolphins have won three straight one-score games against mediocre opposition, and the Browns generally fit in that category. It’s just impossible to know if the final margin will be three or six.

Indianapolis Colts @ Las Vegas Raiders (Nov. 13, 4:05 p.m. ET)

Colts +6 (-110) @ Raiders -6 (-110)

Both of these teams are a mess.

Indianapolis fired head coach Frank Reich Monday after a blowout loss to New England, while the Raiders let a 17-point lead slip in Jacksonville to fall to 2-6.

I’ve been burned too many times to back Las Vegas at this price, but putting money on the Colts feels like a bad idea too.

Dallas Cowboys @ Green Bay Packers

Cowboys -5 (-110) @ Packers +5 (-110)

Mike McCarthy‘s first game back at Lambeau comes at an interesting time, as the much-maligned coach leads the 6-2 Cowboys into Green Bay to face a Packers squad in the midst of a five-game losing streak.

Aaron Rodgers and the offense are a mess, and scoring on this Dallas defense has been difficult. Still, this line feels like a bit of a trap.

Arizona Cardinals @ Los Angeles Rams

Cardinals +3.5 (-114) @ Rams -3.5 (-106)

Sean McVay has dominated Kliff Kingsbury since the latter took over the Cardinals in 2019, winning seven of eight meetings — including a 20-12 victory in Arizona back in September.

Both of these teams really need a win to keep their playoff hopes alive, but I trust the Rams to get the job done.

I’d consider waiting for this spread to drop down to three, though.

Los Angeles Chargers @ San Francisco 49ers (Sunday Night Football)

Chargers +7 (-110) @ 49ers -7 (-110)

At first look, this number felt a bit too high.

Then again, the Chargers are the walking wounded, while the 49ers are coming off a week of rest for key players like Deebo Samuel.

I’m not sure I’d lay the points here, but teasing San Francisco down makes a lot of sense.

Washington Commanders @ Philadelphia Eagles (Monday Night Football)

Commanders +10.5 (-110) @ Eagles -10.5 (-110)

Taylor Heinicke has been a covering machine since taking over the starting job from Carson Wentz. Facing this Philadelphia defense will be his toughest test yet, especially since Washington managed just eight points in the first meeting with Wentz under center.

I don’t see the Eagles’ unbeaten start coming to an end here, but I think there’s a chance the Commanders could sneak in the back door.


John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the last two men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

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