NFL Week 1 Odds | Moneyline, Spread, & Total

Last Updated: Jan 23, 2023

The wait is finally over.

Week 1 of the 2022 NFL season has arrived and we’ve got 16 exciting matchups on tap to kick off the year. Although we’ve been able to bet on these games for a while, we’ll see plenty of line movement this week as money starts to pour in.

Here are the current Week 1 NFL odds and lines for the 2022 season.

NFL Week 1 Odds & Lines

Week 1 NFL odds are courtesy of FanDuel Sportsbook and current as of Tuesday, Sept. 6 at 11:45 a.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 1.

NFL Week 1 Games

Buffalo Bills @ Los Angeles Rams (NFL Kickoff)

Bills -2.5 (-105) @ Rams +2.5 (-115)

Despite winning Super Bowl 56, the Rams are home underdogs in the season opener against Josh Allen and the Bills. The home team has won seven of the last nine NFL Kickoff games, which has me leaning toward backing Matthew Stafford, despite his potential injury concerns.

New Orleans Saints @ Atlanta Falcons (Sept. 11, 1 p.m. ET)

Saints -5.5 (-110) @ Falcons +5.5 (-110)

The Saints and Falcons open up the season with an NFC South clash in Atlanta. These two teams split the season series last year, with the road team winning on each occasion. I’d expect New Orleans to come out on top in this one as their defense should be a bit too much for Marcus Mariota in his Falcons debut.

San Francisco 49ers @ Chicago Bears

49ers -6.5 (-120) @ Bears +6.5 (+102)

Two of the most electric dual-threat quarterbacks in the NFL will share the field on Sunday when Justin Fields and the Bears host the San Francisco 49ers at Soldier Field in the first game of the Trey Lance era.

After falling in the NFC Championship Game to the division rival Rams, the 49ers decided to move on from Jimmy Garoppolo, who is somehow still on San Francisco’s roster. While keeping Jimmy G as a backup isn’t exactly confidence-inducing, Lance has more than enough talent around him to get the win and cover this number.

Pittsburgh Steelers @ Cincinnati Bengals

Steelers +6.5 (-115) @ Bengals -6.5 (-105)

The Steelers have put their faith in Mitch Trubisky, who was not only named the starting quarterback ahead of first-round pick Kenny Pickett, but is also a team captain. He’ll have the tough task of going toe-to-toe with Joe Burrow and the high-flying Bengals’ offense, which added some much-needed help up front in the offseason.

This is a pretty big number for a divisional game, although Cincinnati did outscore Pittsburgh 65-20 in two meetings last season. Steelers coach Mike Tomlin is one of the best at covering the spread as an underdog (64.4% since 2007), so I’ll probably stay away from this one.

Philadelphia Eagles @ Detroit Lions

Eagles -3.5 (-114) @ Lions +3.5 (-106)

There’s a lot of love in the market for Dan Campbell‘s squad, as money has come in on the Lions throughout the summer and early this week to push this line down. Detroit made some improvements over the offseason, but it’s still hard to trust Jared Goff.

I think Philadelphia is the much better team, but it’s probably worth waiting to see if you can catch a -3 before kickoff.

New England Patriots @ Miami Dolphins

Patriots +3.5 (-110) @ Dolphins -3.5 (-110)

The new-look Dolphins will look to make a statement against the AFC East rival Patriots in their first game under Head Coach Mike McDaniel. Miami has won four of its last five home games against New England and should have the talent advantage in this one. (That feels weird to say…)

Look for Tyreek Hill to have a big impact in his first game with the Dolphins after being traded by the Chiefs during the offseason. Back Miami as your NFL pick of the day.

Baltimore Ravens @ New York Jets

Ravens -6.5 (-118) @ Jets +6.5 (-104)

There are still some quarterback questions to be answered in this game as Lamar Jackson hasn’t received a new contract and Zach Wilson hasn’t officially been ruled out of a return from his preseason knee injury.

Still, I expect the Jets won’t risk their second-year quarterback just yet, leaving Joe Flacco to take on his former team. While it’s tempting to bite on the revenge narrative, Ravens coach John Harbaugh has eased any concerns about his quarterback not being ready, and this Baltimore squad is too deep for New York.

Jacksonville Jaguars @ Washington Commanders

Jaguars +2.5 (-105) @ Commanders -2.5 (-115)

Money has come in on the Jaguars over the course of the summer as this line has dropped by 1.5-2 points in some places. Jacksonville was one of the biggest spenders in free agency and should be much improved this season under a proven, Super Bowl-winning coach in Doug Pederson.

It’s hard to say the same about the Commanders, who thought Carson Wentz was an upgrade to their quarterback situation. The Jaguars to win outright is one of my favorite bets of the week.

Cleveland Browns @ Carolina Panthers

Browns +2.5 (-108) @ Panthers -2.5 (-112)

If you’re looking for a revenge narrative to back, this is probably it. Baker Mayfield will make his Panthers debut against his former team, who will start Jacoby Brissett at quarterback as Deshaun Watson starts to serve his 11-game suspension.

If you can grab the Under at 42 or higher, that’s probably worth a play as well, but I trust Carolina to rally around their new quarterback and come out with a hard-fought win.

Indianapolis Colts @ Houston Texans

Colts -7.5 (-104) @ Texans +7.5 (-118)

The Texans’ defense probably isn’t excited about facing Jonathan Taylor in their season opener after the Colts running back tore them apart in 2021, rushing for 288 yards and four touchdowns on just 46 carries.

Based on that information, it probably won’t surprise you to hear that Indianapolis outscored Houston 62-3 across two meetings last season. Still, Davis Mills put together some decent performances in the second half of the year, and I’m not sure I’m willing to lay more than a touchdown in Matt Ryan‘s Indy debut.

New York Giants @ Tennessee Titans (Sept. 11, 4:25 p.m. ET)

Giants +5.5 (-110) @ Titans -5.5 (-110)

The Brian Daboll era begins for the Giants with a difficult trip to Tennessee. There are still plenty of questions surrounding fourth-year quarterback Daniel Jones, who will have to prove himself in an offensive system that worked wonders for Allen and the Bills over the last few years.

The Titans are always one of the most underrated teams in the league, and I don’t think this number is high enough. However, the Under may be an even better bet in a game between two teams that will look to feature their running backs.

Green Bay Packers @ Minnesota Vikings

Packers -1.5 (-115) @ Vikings +1.5 (-105)

There are a lot of unanswered questions about both teams heading into this Week 1 NFC North matchup. What does Green Bay’s offense look like without Davante Adams? How will the Vikings adjust under new coach Kevin O’Connell?

I’d lean toward the home team in this one, but they’re a better teaser piece than a bet.

Kansas City Chiefs @ Arizona Cardinals

Chiefs -5.5 (-115) @ Cardinals +5.5 (-105)

This spread for this matchup has moved 2.5 points since July, and we already knew then that DeAndre Hopkins would miss out because of his four-game PED suspension.

The Cardinals tend to start seasons better than they end them, however, so I might stay away here as the number keeps growing.

Las Vegas Raiders @ Los Angeles Chargers

Raiders +3.5 (-118) @ Chargers -3.5 (-104)

One of the most highly-anticipated games on the slate offers up a rematch of the memorable Week 18 SNF matchup that almost ended in a tie. Daniel Carlson‘s buzzer-beating field goal in overtime helped the Raiders advance to Wild Card weekend while dooming the rival Chargers to another wasted season.

There’s a revenge narrative for Justin Herbert and the Bolts here, but I’m staying away from the spread in what should be one of the highest-scoring games of the weekend.

Tampa Bay Buccaneers @ Dallas Cowboys (Sunday Night Football)

Buccaneers -2.5 (-108) @ Cowboys +2.5 (-112)

After a 40-day retirement, Tom Brady is back for Year 23. (Yes, that sentence still sounds absurd to me, too.)

Brady’s Buccaneers will open with the Cowboys for a second consecutive year, having defeated Dallas 31-29 in the 2021 NFL Kickoff game after Tampa Bay won Super Bowl 55. The 45-year-old quarterback may no longer have Rob Gronkowski, who actually retired (for now, anyway) this offseason, but he’s still got Mike Evans and Leonard Fournette.

The Tampa o-line has some concerns, as does Dallas’ offense after losing Amari Cooper and Cedrick Wilson in the offseason. I don’t hate the Bucs at this number, but the Under may be worth a look.

Denver Broncos @ Seattle Seahawks (Monday Night Football)

Broncos -6.5 (-106) @ Seahawks +6.5 (-114)

After 10 seasons with the Seahawks, Russell Wilson will return to Seattle to face his former team in his Broncos debut on Monday Night Football.

It’ll be quite the spectacle to see Wilson walk onto Lumen Field in anything other than blue and green, but the game itself doesn’t look to be so exciting. Expect Denver to start a little slow, but then put Seattle away in the second half.


John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the last two men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

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