NFL Week 1 Odds

Last Updated: Sep 6, 2023

The schedule and betting lines for Week 1 of the NFL season are set and we’re looking to find great value wagers.

There are 16 exciting matchups on tap, we’ll see plenty of line movement this week as money starts to pour in.

Here are the current Week 1 NFL odds and lines for the 2023 season.

NFL Week 1 Odds & Lines

Keep tabs on all of our current NFL odds leading into NFL Week 1.

Week 1 lines are courtesy of DraftKings Sportsbook and current as of Tuesday, August 5, at 11:00 a.m. ET.

Detroit Lions @ Kansas City Chiefs

Thursday, Sept. 7, 8:20 p.m. ET

  • Lions +6.5 (-115) @ Chiefs -6.5 (-105)

The NFL season opener should be a high-scoring affair between two potent offenses with an Over/Under set at 54.5.

Patrick Mahomes certainly has the advantage over Jared Goff. The Lions may have an added edge this season between rookies RB Jahmyr Gibbs and TE Sam LaPorta, but can Amon-Ra St. Brown go toe-to-toe with Travis Kelce?

(Update: Kelce hyperextended his knee Tuesday. His status is in question for Week 1.)

This matchup may be closer than we think, although home-field advantage in Arrowhead Stadium to start the season will be tough to beat.

I’ll take the points and the Lions at +6.5 in a tight Chiefs victory.

Cincinnati Bengals @ Cleveland Browns

Sunday, Sept. 10, 1 p.m. ET

  • Bengals -2.5 (-110) @ Browns +2.5 (-110)

The Battle of Ohio presses on in what will be the rivalry’s 100th matchup. Deshaun Watson needs to start the season well after what was a disappointing return to action last season.

Do the Browns have much of an answer for Ja’Marr Chase? In his one game against the Browns last season, the stud receiver posted 10 receptions for 119 yards and a touchdown.

There’s too much firepower in Cincinnati’s offense. Bengals -2.5 is the pick.

Houston Texans @ Baltimore Ravens

Sunday, Sept. 10, 1 p.m. ET

  • Texans +10 (-110) @ Ravens -10 (-110)

The C.J. Stroud era kicks off on the road against the Ravens. He’ll be put to the test right away with injuries along Houston’s offensive line.

Lamar Jackson should be excited to play and will be fully healthy, as he hasn’t played a full game since Week 12 of the 2022 season.

The Texans also want to see DE Will Anderson Jr. hit the field for the first time. He was the No. 3 overall pick in this year’s draft and will look to anchor this defense for years to come.

Jackson will be too much for this defense to handle, but the spread is too wide. Take the Texans +10 for my NFL bet of the day.

Tampa Bay Buccaneers @ Minnesota Vikings

Sunday, Sept. 10, 1 p.m. ET

  • Bucs +6 (-110) @ Vikings -6 (-110)

The Buccaneers have put their trust in Baker Mayfield to pick up where Tom Brady left off. The talent is still there in WRs Mike Evans and Chris Godwin.

However, the Vikings are heavy favorites for good reason. Justin Jefferson had another monster season and the midseason addition of T.J. Hockenson added a new dimension to this offense last season.

Blowout alert. Give me the Vikings at -6.

Carolina Panthers @ Atlanta Falcons

Sunday, Sept. 10, 1 p.m. ET

  • Panthers +3.5 (-105) @ Falcons -3.5 (-115)

Bryce Young could put his stamp on the 2023 season with a big NFC South win over Atlanta. A retooled Panthers offense has been overhauled this offseason, so any skepticism has merit.

The Falcons also have a young quarterback with plenty to prove in Desmond Ridder. All eyes will likely be on Atlanta’s new workhorse RB Bijan Robinson, selected with the No. 8 overall selection.

The Falcons love to establish the run and that’s why they were happy to select the star prospect so early in the first round.

Atlanta will rush for 250 yards as it will cover -3.5.

Arizona Cardinals @ Washington Commanders

Sunday, Sept. 10, 1 p.m. ET

  • Cardinals +7 (-110) @ Commanders -7 (-110)

Arizona has a new head coach in Jonathan Gannon and will look to get back on track in the NFC West this year. Kyler Murray will not as he recovers from a torn ACL. Arizona cut Colt McCoy and as of publishing, the starting job either belongs to Joshua Dobbs or Clayton Tune.

The Commanders are calling upon 2022 fifth-rounder Sam Howell to lead the offense. Between Brian Robinson, Logan Thomas, Jahan Dotson, and Curtis Samuel, this offense has to do better. Terry McLaurin may be unable to play due to a lingering toe injury.

Arizona can’t keep it close, making the Commanders -7 the pick.

Jacksonville Jaguars @ Indianapolis Colts

Sunday, Sept. 10, 1 p.m. ET

  • Jaguars -5 (-112) @ Colts +5 (-108)

The breakout 2022 performance for Trevor Lawrence has expectations high in Jacksonville. Adding Calvin Ridley via trade only gives him more weapons at his disposal.

We’ll be getting our first look at rookie QB Anthony Richardson. This offense needs a spark in the passing game to as the team will be without Jonathan Taylor.

Jaguars will be too much on offense for the Colts. Expect the Jaguars to cover -5.

San Francisco 49ers @ Pittsburgh Steelers

Sunday, Sept. 10, 1 p.m. ET

  • 49ers -2.5 (-110) @ Steelers +2.5 (-110)

The 49ers dropped their Week 1 game in heavy rains against the Bears last year. They’ll be hoping to avoid another letdown game to start this season.

Brock Purdy will start and he’ll be handing off early and often to Christian McCaffrey.

Kenny Pickett and the Steelers scored just 18.1 points per game, tied for the sixth fewest in the league. Keep an eye out for breakout candidate WR George Pickens, who already impressed often in his rookie season last year.

The 49ers shut down the Steelers offense in a low-scoring affair. The 49ers are the pick at -2.5.

Tennessee Titans @ New Orleans Saints

Sunday, Sept. 10, 1 p.m. ET

  • Titans +3 (-105) @ Saints -3 (-115)

The Titans blew up their coaching staff and offense. Ryan Tannehill has the starting job, but will a slow start to the season necessitate a move to Will Levis?

They’ll need guys like DeAndre Hopkins, Treylon Burks, and Chigoziem Okonkwo to step up as Derrick Henry can’t do it alone.

New Orleans must get Chris Olave and Michael Thomas going in this game to stake an early lead. The Saints 7-10 record last year was the first losing season since 2016.

Take the Saints at -3.

Las Vegas Raiders @ Denver Broncos

Sunday, Sept. 10, 4:25 p.m. ET

  • Raiders +4 (-110) @ Broncos -4 (-110)

The Raiders are hoping Jimmy Garoppolo can bring consistency to an offense that lacked a consistent passing attack last season. It certainly helps to have Davante Adams, Jakobi Meyers, and Hunter Renfrow.

Denver’s big offseason coup wasn’t a player, but it was bringing on head coach Sean Payton, who will look to get Russell Wilson back on track after a disastrous 2022 season.

The Broncos are going to be toying with the Raiders by the fourth quarter en route to covering -4.

Philadelphia Eagles @ New England Patriots

Sunday, Sept. 10, 4:25 p.m. ET

  • Eagles -4 (-112) @ Patriots +4 (-108)

The Eagles offense might be even better with D’Andre Swift added to the backfield to go along with A.J. Brown, DeVonta Smith, and Dallas Goedert.

The Patriots need Mac Jones to reestablish the upside he put on display in his rookie season. Signing JuJu Smith-Schuster should help, but this is mostly the same offense we saw last season that was one-dimensional.

Philly should take this spread personally. Back the Eagles at -4.

Los Angeles Rams @ Seattle Seahawks

Sunday, Sept. 10, 4:25 p.m. ET

  • Rams +5.5 (-110) @ Seahawks -5.5 (-110)

Los Angeles will see Cam Akers more touches with Cooper Kupp out this week.

As if Seattle needed more firepower at wide receiver, they used a first-round choice on Jaxon Smith-Njigba to form a ruthless trio with DK Metcalf and Tyler Lockett.

The Rams cover the spread of +5.5, but lose the game.

Miami Dolphins @ Los Angeles Chargers

Sunday, Sept. 10, 4:25 p.m. ET

  • Dolphins +2.5 (-110) @ Chargers -2.5 (-110)

Tyreek Hill and Jaylen Waddle were one of the most devastating one-two punches at wide receiver across the NFL. Who knows what could have been if Tua Tagovailoa stayed healthy and didn’t miss any time.

The Chargers had the opposite problem. Their duo of Keenan Allen and Mike Williams couldn’t stay healthy.

A long-term solution was drafted in the first round, as the Chargers selected WR Quentin Johnson. Their production should take pressure off of Austin Ekeler and Justin Herbert.

Dolphins win this one outright, the +2.5 spread opens the door for a great teaser opportunity.

Green Bay Packers @ Chicago Bears

Sunday, Sept. 10, 4:25 p.m. ET

  • Packers +1 (-112) @ Bears -1 (-108)

What a leap forward Justin Fields took in his progression last year. The Bears let David Montgomery walk via free agency and added D’Onta Foreman to work in tandem with Khalil Herbert.

Green Bay will also be leaning heavily on its RB duo, Aaron Jones and A.J. Dillon. With Aaron Rodgers traded to the Jets, Jordan Love will need a sturdy running game to open up play-action passes.

The Bears are one of the sleeper teams of 2023. Expect them to cover -1 and win against the Pack.

Dallas Cowboys @ New York Giants

Sunday, Sept. 10, 8:20 p.m. ET

  • Cowboys -3.5 (-102) @ Giants +3.5 (-118)

The Cowboys have to avoid a loss in order to set the tone for the year. They’re coming off back-to-back disappointing playoff finishes and this is a prime example of a team that may have lost their mojo.

It certainly helps to have Tony Pollard given the starting RB job. Meanwhile, Daniel Jones’ 2022 season gave the Giants new life.

It also helps that Saquon Barkley played in 16 games for the first time since his 2018 rookie season.

I’m most excited to see what Brandin Cooks can provide the Cowboys’ passing game with him not having to be the team’s No. 1 receiver.

Dexter Lawrence and the rest of the Giants defense keep this one close, so take the +3.5.

Buffalo Bills @ New York Jets

Monday, Sept. 11, 8:15 p.m. ET

Bills -2.5 (-112) @ Jets +2.5 (-108)

Josh Allen looked otherworldly in last season’s Week 1 game against the Rams. He passed for 297 yards with three TDs plus another 56 rushing yards and a score.

We didn’t yet know that Los Angeles wasn’t quite themselves, and the same could be said about this game.

Will Aaron Rodgers and the Jets’ offense hit the ground running? My money’s on Allen putting on a show while Rodgers faces an uphill battle as he gels with New York’s playmakers.

Vegas is giving the Jets way too much respect. Take the Bills -2.5.


Matt De Lima

Matt is a sports content editor at The Game Day with more than 10 years experience in the fantasy and betting spaces. He is a two-time Fantasy Sports Writing Association award finalist with previous experience working for Sports Illustrated, Full Time Fantasy, FFToolbox, 4for4, and RotoExperts. Born and raised in California, Matt now calls southern Maryland home. He is a Virginia Tech alumnus and a life-long 49ers, Lakers, and Dodgers fan.

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