NFL Week 1 Odds | Opening NFL Moneyline, Spread, & Total Betting Lines

Posted: Jul 11, 2022Last updated: Aug 3, 2022

The 2022 NFL season is right around the corner and it’s never too soon to look ahead at the Week 1 lines. With training camps and the preseason yet to begin, this is the time to grab some value for Week 1 before the odds start to shift.

So what bets should you make now and what games should bettors keep an eye on over the next several weeks?

Here are the current Week 1 NFL odds and lines for the 2022 season.

NFL Week 1 Odds & Lines

Week 1 NFL odds are courtesy of FanDuel Sportsbook and current as of Monday, July 11 at 1 p.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 1.

NFL Week 1 Games

Buffalo Bills @ Los Angeles Rams (NFL Kickoff)

Bills -1 (-110) @ Rams + 1 (-110)

The season’s opening game should be a fantastic one as two of the best offenses in the league will face off in Los Angeles. It’s a bit surprising to see the Rams listed as a slight home underdog, despite winning the Super Bowl last year. However, that line will likely move in their favor by kickoff, so don’t be afraid to bet it now.

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New Orleans Saints @ Atlanta Falcons (Sept. 11, 1 p.m. ET)

Saints -5.5 (-110) @ Falcons +5.5 (-110)

One of the most puzzling Week 1 lines features the Falcons being underdogs of less than a touchdown to the Saints. Atlanta might have one of the worst rosters in the NFL and will have a new starting quarterback in Marcus Mariota.

The Saints will be getting back Jameis Winston from his ACL injury as he is fully cleared to participate in training camp. New Orleans has a fantastic defense and should be able to keep the Falcons under 17 points. For that reason alone, the Saints are a great bet at -5.5, despite being on the road against a divisional opponent.

San Francisco 49ers @ Chicago Bears

49ers -6.5 (-110) @ Bears +6.5 (-110)

These two teams played in Chicago last year and it was a fantastic game in which Justin Fields rushed for over 100 yards. It was the first breakout game for the former Ohio State quarterback.

Both teams will start sophomore quarterbacks (Trey Lance, Fields) here in Week 1, but the 49ers’ roster is undeniably better than the Bears. Still, this is a line that bettors should probably stay away from as 6.5 points is a lot for a team playing a Year 2 quarterback with only two starts under his belt.

Pittsburgh Steelers @ Cincinnati Bengals

Steelers +6.5 (-110) @ Bengals -6.5 (-110)

The Bengals dominated the Steelers in both meetings last season, but that was with Ben Roethlisberger under center. So how will Mitch Trubisky fare against the defending AFC Champions? Probably not a whole lot better.

Still, it’s probably wise to stay away from this line, given that it is a divisional game and there is still a lot of uncertainty about what Pittsburgh’s offense will look like with a new quarterback.

Philadelphia Eagles @ Detroit Lions

Eagles -4.5 (-110) @ Lions +4.5 (-110)

The Eagles have one of the most talented rosters from top to bottom, but there are still some major concerns about Jalen Hurts at quarterback. They are heavy favorites over the Lions in Detroit, but this is a sneaky dangerous line.

While the obvious pick is to take the Eagles -4.5, this game has all the makings of a potential Week 1 upset as Detroit’s roster is much improved compared to last year.

New England Patriots @ Miami Dolphins

Patriots +2.5 (-110) @ Dolphins -2.5 (-110)

The Patriots have historically struggled in Miami, especially in September. They just aren’t used to the heat and they’ve lost several games recently to the Dolphins.

With Tyreek Hill now in the fold for Miami, they have one of the fastest receiving duos in NFL history. Betting on the Dolphins -2.5 might be the play before that line rises to -3 or even -3.5 before kickoff. Make this your NFL pick of the day.

Baltimore Ravens @ New York Jets

Ravens -6 (-110) @ Jets +6 (-110)

One of the biggest locks of Week 1 is taking the Ravens -6 against the Jets. While the Jets have rebuilt their roster this offseason, they are still counting on a ton of young players to make leaps this year. In addition, their secondary is entirely new and their linebacking core is still a significant issue.

Lamar Jackson is usually dynamite to start the season and he should rip through the Jets’ young defense in Week 1. Plus, Baltimore’s defense is finally healthy again, which will spell trouble for second-year quarterback Zach Wilson. Don’t be afraid to bet on Baltimore before that line rises.

Jacksonville Jaguars @ Washington Commanders

Jaguars +4 (-110) @ Commanders -4 (-110)

The Commanders have another new Week 1 starter after trading for Carson Wentz earlier this offseason. But the real story here is Doug Pederson and the Jacksonville Jaguars. Can he get the franchise back to a competent place after the Urban Meyer disaster? If the answer is yes, don’t be surprised if they pull off the upset and beat the Commanders in Week 1.

Jaguars +4 seems like a pretty decent value heading into training camps.

Cleveland Browns @ Carolina Panthers

Browns -1 (-110) @ Panthers +1 (-110)

The Panthers will have a new starting quarterback again this season and his name is Baker Mayfield. His first game with Carolina comes against his former team and you know that he will want to put on a show.

However, it’s best to avoid this line right now as we still don’t know the status of Deshaun Watson. Plus, it’s fair to wonder how healthy Mayfield is and will be after undergoing shoulder surgery this offseason. Neither side is all that attractive in July as we still have a lot to learn about both squads.

Indianapolis Colts @ Houston Texans

Colts -8 (-110) @ Texans +8 (-110)

The Colts outscored the Texans 62-3 last season as Jonathan Taylor ran right through them. That could be the case again in Week 1 as the Texans didn’t do much to address their defensive line.

It’s always dangerous betting on new starting quarterbacks (Matt Ryan) on the road against a divisional opponent, but the talent differential between these two squads is massive.

New York Giants @ Tennessee Titans (Sept. 11, 4:25 p.m. ET)

Giants +6.5 (-115) @ Titans -6.5 (-105)

The Giants have a new coaching staff under Brian Daboll and they will be tested early against the AFC’s No. 1 seed from last year. The Titans have a fantastic pass rush that could get after Daniel Jones in Week 1.

This is a pretty big line for the opening game of the season, so it might be best to stay away until we see both of these teams in the preseason.

Green Bay Packers @ Minnesota Vikings

Packers -1.5 (-110) @ Vikings +1.5 (-110)

The Vikings have had some recent success against the Packers at home, but that was under Mike Zimmer. Can they continue to find ways to slow down Aaron Rodgers with a new-look coaching staff?

Early-season divisional games are always tough to predict, so grabbing the home team and the points might be the way to go.

Kansas City Chiefs @ Arizona Cardinals

Chiefs -3 (-110) @ Cardinals +3 (-110)

Andy Reid has a career record of 16-8 in Week 1 and his Chiefs have won their season-opener in each of the last seven years. What’s even more impressive is that Kansas City has scored 30 or more points in Week 1 in six straight seasons.

They’ll face the Cardinals, who will be without No. 1 receiver DeAndre Hopkins due to a PED suspension. This might be the time to jump on Chiefs -3 as that line could move significantly over the next two months.

Las Vegas Raiders @ Los Angeles Chargers

Raiders +4 (-110) @ Chargers -4 (-110)

The Raiders beat the Chargers in Week 18 last year to advance to the playoffs in a win-or-go-home game for both teams. But the rosters couldn’t be any more different going into this Week 1 contest. With both teams looking much improved, the value here is taking the points with the Raiders.

Tampa Bay Buccaneers @ Dallas Cowboys (Sunday Night Football)

Buccaneers -2.5 (-110) @ Cowboys +2.5 (-110)

This was the opening game of the 2021 season and the Buccaneers won 31-29 after another game-winning drive by Tom Brady. But this game is in Dallas, and the Cowboys have opened as slight home dogs.

There might be some value on the Cowboys here, considering the Buccaneers likely won’t have Chris Godwin (ACL) available and will still be adjusting after the recent retirement of Rob Gronkowski.

Denver Broncos @ Seattle Seahawks (Monday Night Football)

Broncos -5 (-110) @ Seahawks +5 (-110)

Russell Wilson‘s first game with the Broncos will be against his former team in Seattle. There will likely be a ton of action on the Broncos in this game as the excitement builds around Wilson in Denver.

However, Pete Carroll‘s teams always play well at home and five points is quite a bit. So keep an eye on this spread as it could move to Seattle +5.5 or even +6 before Week 1 begins.


Marcus Mosher

Marcus Mosher is an NFL analyst at The Game Day, residing in Erie, PA. He covers the NFL from a betting and fantasy perspective, producing written and video content. Marcus currently hosts multiple football-related podcasts and is a managing editor at USA Today’s Sports Media Group covering the Las Vegas Raiders. He has previously worked at The Athletic and Bleacher Report.

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