Panthers vs Seahawks Predictions & Best Bets

Last Updated: Sep 20, 2023

The Carolina Panthers will travel to Seattle’s Lumen Field to face the Seahawks in what is one of the more hostile home-field environments in the NFL. Will Panthers rookie quarterback Bryce Young be able to overcome the noise in search of his first career win? Or, will Geno Smith and the Seahawks handle business and advance to 2-1?

The Seahawks surprised everyone last season when they went 9-8 and made the playoffs behind Smith’s 30 TD passes and Comeback Player of the Year Award. Can Smith and the Seahawks build on last year’s success?

Let’s dig into some potential winning wagers for Week 3’s Carolina vs Seattle matchup.

Panthers vs Seahawks Odds

NFL odds used for this Carolina vs Seattle preview were found at DraftKings Sportsbook and are current as of Wednesday, Sept. 20 at 12 p.m. ET.

  • Moneyline: Seahawks (-238) • Underdog (+195)
  • Spread: Seahawks -6 (-105) • Panthers +6 (-115)
  • Total Points: Over 42 (-110) • Under 42 (-110)
  • Implied Score: Seahawks 24, Panthers 18

Panthers vs Seahawks Predictions

Score Pick: Seahawks 27, Panthers 17

The Seahawks dynamic receiving trio of Tyler Lockett, DK Metcalf, and Jaxon Smith-Njigba should have no issues creating separation against a secondary missing their top cover corner in Jaycee Horn.

Bryce Young and the Panthers offense hasn’t been able to find their footing thus far through two weeks. Young ranks second-to-last in the NFL in passing yards per game (149.5), behind only fellow rookie quarterback Anthony Richardson, who left his Week 2 game against the Houston Texans early in the first half due to a concussion.

The Seahawks should have no issues defeating the Panthers on their home field and winning their second consecutive game after a rough Week 1 loss to the Los Angeles Rams.

Panthers vs Seahawks Best Bets & Props

Geno Smith: Over 1.5 Passing Touchdowns (-130)

DraftKings Sportsbook • WAGER: 2 Units

The Seahawks are hoping to welcome 2022 first-round pick Charles Cross back into the fold from a toe injury. This should patch up the offensive line and give Smith enough time to read through his progressions and carve up a Panthers secondary that just lost Jaycee Horn to a hamstring injury.

Smith threw three touchdowns in the Seahawks 30-24 loss to the Panthers, making this my NFL bet of the day.

Seahawks Over 23.5 (-115)

DraftKings Sportsbook • WAGER: 1 Unit

The Seahawks ranked 10th in the NFL in points per game last season, averaging 23.9 PPG. It has been much the same story in 2023, with the team averaging 25 points per game after two games.

The Seattle offense is filled with talented playmakers, starting with the two young running backs in Kenneth Walker and Zach Charbonnet, the team’s second-round draft picks in each of the last two seasons. Not to mention, they have arguably the best receiving trio in the NFL between Metcalf, Lockett, and first-round rookie Jaxon Smith-Njigba.

If Cross suits up, it will be a big boost for the offensive line. The Seahawks scored 24 points against this same Panthers defense last season, and Carolina is now missing Horn and Shaq Thompson.

Alternate Spread: Seahawks -9.5 (+144)

DraftKings Sportsbook • WAGER: 0.5 Units

The absences of Horn and Thompson on the defensive end cannot be overstated. They have been key cogs in this defensive unit for years, and the Seahawks should have no problems moving the ball down the field and scoring enough points to cover this big alternate spread.

Young has also struggled mightily in his first two NFL games, and his supporting cast still leaves much to be desired outside of veteran wide receiver Adam Thielen.

Take the Seahawks to roll at home and avenge last season’s loss to the Panthers.

Panthers vs Seahawks Same Game Parlay

Panthers vs Seahawks SGP (+171)

DraftKings Sportsbook • WAGER: 1 Unit

  • Seahawks (-238)
  • Over 42 (-110)

The Panthers are 3-8 in their last 11 meetings with the Seahawks, and the Over has hit in each of the past five games they’ve played in Seattle.

After a Week 1 performance that left people wondering if Smith’s 2022 campaign was a mirage, he bounced back in a big way in the Seahawks Week 2 win versus the Detroit Lions. The Seahawks defense also stepped up, forcing three turnovers and two sacks while scoring a touchdown against the Lions.

Expect Smith and the defense to carry that momentum into a Week 3 home game against an 0-2 opponent with a depleted defense and a rookie quarterback who does not yet look comfortable as an NFL signal-caller.


Lior Lampert

Lior is an NBA/NFL writer for The Game Day. He earned a BA in English and MS in Sports Analytics in Management during his time as a student. Since then, Lior has been writing content for FanSided, GMEN HQ, and GameTime Sharks among other pages regarding the NFL, NBA, Tennis, fantasy football, and sports betting to develop a career in the sports media industry. Born in Israel but raised in New York, Lior is a long-time fan of his hometown New York Knicks and Giants. Not only does he enjoy covering sports, he enjoys playing basketball, tennis, and pickleball.

Related articles


Get $1,500 in Bonus Bets

5 stars

Bet $5, Get $150 in Bonus Bets or First Bet Safety Net

5 stars

Bet $10, Get $200 in Bonus Bets

5 stars

Get A Bonus Bet Up to $1,000

5 stars

Bet $5, Get $200 in Bonus Bets

5 stars

Get Up To $250 Second Chance Bonus Bet

5 stars

If you or someone you know has a gambling problem and wants help, please call 1-800-GAMBLER.

21+ and present in OH. Gambling Problem? Call or text 1-800-GAMBLER (CO, DC, IL, IN, LA, MD, MS, NJ, OH, PA, TN, VA, WV, WY).

Call 877-8-HOPENY or text HOPENY (467369) (NY).

Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-270-7117 for confidential help (MI).

All betting content on is exclusively intended for audience members 21 years and older who are permitted to gamble in legal states. The Game Day may earn revenue from site visitor referrals to betting services.

Responsible Gaming: Many sportsbooks offer ways to encourage responsible gaming, including the establishment of limits to deposits, spending, and time dedicated to betting.

The Game Day is a TGD Marketing Ltd. endeavor.