Rams vs Colts Predictions & Best Bets

Last Updated: Sep 28, 2023

The Los Angeles Rams will be traveling to face the Indianapolis Colts in Week 4, hoping to right the ship after losing their last two games. The Colts are coming off an impressive road victory against the Baltimore Ravens with backup quarterback Gardner Minshew under center. The Colts have won two consecutive games and will look to keep the good times rolling against a reeling Rams team.

Rams vs Colts Odds

NFL odds used for this Los Angeles vs Indianapolis preview were found at DraftKings Sportsbook and are current as of date and time ET.

  • Moneyline: Colts (-115) • Rams (-105)
  • Spread: Colts -1 (-110) • Rams +1 (-110)
  • Total Points: Over 46.5 (-115) • Under 46.5 (-105)
  • Implied Score: Colts 23.75 • Rams 22.75

Rams vs Colts Predictions

Score Pick: Rams 27, Colts 19

Colts rookie quarterback Anthony Richardson returned to practice this week after sitting out last week due to a concussion. As of this writing, Richardson hasn’t cleared the NFL’s concussion protocol but is trending in the right direction. With that said, we will be operating as if Richardson will suit up for the Colts on Sunday.

After a down 2022 season, Rams quarterback Matthew Stafford has looked more like the Super Bowl-winning signal-caller he was in 2021. He’s currently fourth in the NFL in passing yards (910) and facing a young Colts secondary that has been torched by opponents this season, ranking in the bottom 10 in terms of opponent passing yards per game.

Rams head coach Sean McVay and Stafford should have their way against an inexperienced Colts secondary.

Rams vs Colts Best Bets & Props

Rams Over 2.5 Touchdowns (-120)

DraftKings Sportsbook • WAGER: 2 units

Given the Colts’ secondary woes, Stafford and the Rams offense should have little to no problems moving the ball down the field and exposing the Colts through the air. Stafford can potentially exceed two-and-half touchdowns on his own in a very friendly matchup.

Through the season’s first three games, the Rams have averaged 23 points per game. If they can reach/eclipse the 23-point threshold, they will likely score more than two touchdowns in the process, making this my NFL bet of the day.

Rams +1.5 (-110)

DraftKings Sportsbook • WAGER: 1 unit

After dropping their last two games, the Rams enter this game with a sense of urgency to get back to .500 and avoid a potential three-game divisional gap between them and the San Francisco 49ers for first place in the NFC West.

Stafford and McVay are light years ahead of Colts rookie head coach Shane Steichen and quarterback Anthony Richardson in terms of NFL experience, which should give them the upper hand in a game that is expected to be closely contested.

Rams receivers Puka Nacua and Tutu Atwell have emerged as legitimate threats with big-play ability, and the Colts secondary will have a tough time staying in front of them.

It wouldn’t be shocking to see the Rams win outright, but take the points to be safe.

Over 3.5 Fields Goals Made (+115)

DraftKings Sportsbook • WAGER: 0.5 units

Colts kicker Matt Gay exceeded this total on his own in the Colts Week 3 win over the Ravens, successfully connecting on all five of his field goal attempts. Additionally, Rams kicker Brett Maher has made exactly three field goals in every game this season.

The Rams have the second-lowest opponent third down conversion percentage (25.71%). If the Colts can move the ball on a vulnerable Rams defense that bends but doesn’t break, there could be plenty of field goal attempts for Gay.

Rams vs Colts Same Game Parlay

Rams vs Colts SGP (+130)

DraftKings Sportsbook • WAGER: 1 unit

  • Rams Over 21.5 (-140)
  • Rams +1.5 (-115)

Given the Rams offensive production through three games thus far and the secondary concerns of the Colts, Stafford and the Rams should have no issues clearing this point total.

The Rams have covered the spread in six of their last nine games when they face the Colts and six of their last nine games in general. They’ve also won seven of the last 10 meetings against the Colts outright, making this an easy parlay to feel good about heading into Sunday.


Lior Lampert

Lior is an NBA/NFL writer for The Game Day. He earned a BA in English and MS in Sports Analytics in Management during his time as a student. Since then, Lior has been writing content for FanSided, GMEN HQ, and GameTime Sharks among other pages regarding the NFL, NBA, Tennis, fantasy football, and sports betting to develop a career in the sports media industry. Born in Israel but raised in New York, Lior is a long-time fan of his hometown New York Knicks and Giants. Not only does he enjoy covering sports, he enjoys playing basketball, tennis, and pickleball.

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