Chiefs vs Cardinals Predictions & Best Bets

Last Updated: Aug 15, 2023

The Kansas City Chiefs will travel to face the Arizona Cardinals on Saturday in the second week of the NFL preseason. Kansas City is coming off a two-point loss to the New Orleans Saints, while Arizona defeated the Denver Broncos by one point in the first week of the preseason.

Starters from both teams likely aren’t going to receive many – if any – snaps in Saturday’s exhibition contest. Taking that into account, let’s take a look at the best bets and picks for Saturday’s matchup between the Chiefs and the Cardinals.

Chiefs vs Cardinals Odds

NFL odds used for this Kansas City vs Arizona preview were found at DraftKings Sportsbook and are current as of August 15 at 1:40 p.m. ET.

  • Moneyline: Chiefs (-325) • Cardinals (+260)
  • Spread: Chiefs -7.5 (-110) • Cardinals +7.5 (-110)
  • Total Points: Over 40 (-110) • Under 40 (-110)
  • Implied Score: Chiefs 24, Cardinals 16.5

Chiefs vs Cardinals Predictions

Score Pick: Chiefs 24, Cardinals 17

We likely aren’t going to see quarterback Patrick Mahomes much on Saturday, but that doesn’t mean the Chiefs won’t secure the win against a Cardinals team with a new head coach in Jonathan Gannon. After going down 17-0 to begin their first preseason game against the Saints, the Chiefs tied the game at 17 before kicker Blake Grupe hit a game-winning 31-yard field goal for the Saints as time expired late in the fourth quarter.

Andy Reid is 5-2 in the last three years in the preseason (including this year), while it’s hard to generate much opinion on Gannon’s squad after winning his preseason debut at the helm. The reigning Super Bowl champions should get off to a faster start than they did against the Saints in their preseason opener.

Chiefs vs Cardinals Best Bets & Props

Cardinals +7.5 (-110)

DraftKings Sportsbook • WAGER: 1 unit

If this were a regular-season game, the Chiefs should unquestionably be massive favorites over the Cardinals. But with it being an exhibition matchup, it’s tough advising anyone to take the Chiefs to win handily, especially when their starters see limited playing time.

The Cardinals kept it close and defeated the Broncos by one point in their Week 1 preseason bout despite being nearly six-point underdogs. Even if the Chiefs come out firing, unlike their recent preseason loss, the Cardinals can keep this game within seven points.

Chiefs to win by 1-13 points (+140)

FanDuel Sportsbook • WAGER: 0.5 units

As mentioned above, it’s tough to envision a team – even the Chiefs – blowing out an opposing team easily in the preseason. That being said, you can take the Chiefs to win by anywhere between one to 13 points at plus odds on FanDuel.

Taking this bet does give some leeway if the Cardinals cannot cover the spread, giving us a chance to make some money back if Arizona doesn’t keep the game within seven points.

Over 40 (-110)

DraftKings Sportsbook • WAGER: 1 unit

Regardless of how much playing time Mahomes receives, the Chiefs are coming off their preseason opener scoring 24 points after being down 17-0 to begin the game. Kansas City’s offense wants to play fast-paced with every quarterback it deploys and combined for 50 total points versus New Orleans last weekend.

On the other side of the field, the Cardinals tallied 18 points against the Broncos in their first preseason contest. Arizona’s offense is primed for success against a Kansas City defense that surrendered 360 yards and 26 points to New Orleans. The Chiefs also objectively have a worse defense than the Broncos, though it’s still the preseason. This is our NFL bet of the day.

Chiefs vs Cardinals Same Game Parlay

No Same Game Parlays are available for this game, but this section will be updated if they become available.


Skyler Carlin

Before joining The Game Day, Skyler has written for various sites for 5-6 years and his work has been (or is) currently featured on Bleacher Report, USA TODAY, and SB Nation. Skyler can be reached at @skyler_carlin on Twitter and he loves to talk about movies, TV shows, and anything sports. He has taken part in multiple well-known fantasy contests like RazzBowl, Scott Fish Bowl, and NFL DFS Wars.

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