Cardinals vs Broncos Predictions & Odds

Last Updated: Dec 14, 2022

The Arizona Cardinals and Denver Broncos will face off in a Week 15 interconference matchup this Sunday, Dec. 18 at 4:05 p.m. ET.

The Cardinals and Broncos are in similar spots, having disappointing seasons with Arizona at 4-9 and Denver at 3-10. Denver has lost five consecutive games, while Arizona has lost three in a row.

Moreover, the Cards will be without starting quarterback Kyler Murray for the rest of the season after he suffered a torn ACL in Week 14.

Let’s take a look at some Arizona vs Denver best bets, predictions, and betting tips for Week 15.

Cardinals vs Broncos Odds

All odds and lines are current as of Wednesday, Dec. 14, at 1 p.m. ET and are courtesy of Caesars Sportsbook.

The Broncos are listed as 3-point home favorites against the Cardinals, which is understandable considering that these teams are in comparable positions. The total is set at just 36 points, reflecting the quality of each team’s offense right now.

Take a look at the best Cardinals odds and Broncos odds for the 2022 NFL season.

Cardinals vs Broncos Implied Totals

Broncos 19.5, Cardinals 16.5

Bookmakers have the Broncos winning the game by a field goal, but given the likelihood of this being a low-scoring game, it could be a wider gap with Denver’s defense setting the tone.

Cardinals vs Broncos Pick of the Day

Read more on this Cardinals vs Broncos bet below.

Cardinals vs Broncos Prediction

Broncos 17, Cardinals 10

The Broncos are small favorites in this matchup, but I do not believe the spread adequately accounts for the injury to Murray, nor the typical difficulty teams have while playing in Denver.

Denver’s elite defense gives them the edge here with both teams banged up at skill positions. Colt McCoy will do his best to rally the Cards, but after his lackluster performance last week against New England, bettors shouldn’t expect too much from him.

I expect a low-scoring game, but one that remains within one score the whole way through.

Cardinals vs Broncos Bet Tips

Here are a few Cardinals vs Broncos betting trends to consider before making your bets:

  • The Cardinals are 6-7 against the spread, but 3-1 ATS as a road underdog.
  • Denver is 5-8 against the spread and 0-3 ATS as a home favorite.
  • The Cardinals are 2-2 against the spread in non-conference matchups.

Cardinals vs Broncos Best Bets

Broncos -3 (-110) at Caesars Sportsbook

WAGER: 1 Unit

The Broncos have the edge overall in this matchup simply by having a mostly healthy, excellent defense. The Cardinals’ offense will likely be flummoxed out of the gate without Murray, and Denver has the capability to exploit it.

Want to bet on the Broncos? Check out the best CO sportsbooks!

Under 36 Points (-110) at Caesars Sportsbook

WAGER: 1 Unit

This is a very low total to back the Under, but the Broncos’ offense has been anemic all season long with Russell Wilson under center. The Cardinals don’t figure to fare much better against a solid defensive unit and with McCoy figuring to start.

Want to bet on the Cardinals? Check out the best AZ sportsbooks!

Cardinals vs Broncos Props

Check out the best Cardinals vs Broncos player prop bets this week with our props comparison tool. Click on “Show More Games" below to find the Arizona vs Denver game and see all of its prop bets.


Daniel Preciado

Daniel Preciado is a current student at Syracuse University in the sports analytics program where he is minoring in economics. He is a yearly participant in numerous high-stakes fantasy leagues across multiple sports. Prior to joining The Game Day, Daniel Preciado has written for The Action Network, FanSided, and Fantrax.

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