49ers vs Raiders Predictions & Odds

Posted: Dec 27, 2022Last updated: Dec 27, 2022

Though records will tell you differently, this 49ers vs Raiders matchup features two of the hottest teams in the NFL.

Sitting at 11-4, the 49ers are riding an eight-game winning streak. And despite being 6-9, the Raiders have won four of their past six games, hanging on to their playoff lives by a thread.

Let’s take a look at my San Francisco vs Las Vegas best bets and NFL betting tips for Week 17.

49ers vs Raiders Odds

The 49ers enter their Week 17 matchup against the Raiders as -6 road favorites. This is par for the course for the 49ers, as they have won each of their past eight games by at least six points with no signs of slowing down.

Take a look at the best 49ers odds and Raiders odds for the 2022 NFL season.

All odds and lines are current as of 12:30 p.m. ET on Tuesday, Dec. 27, at Caesars Sportsbook.

49ers vs Raiders Implied Totals

49ers 24, Raiders 18

The 49ers are averaging 25 points per game and will face off against one of the worst defenses in the NFL. On the other side, the Raiders are scoring 23.2 ppg and going up against the No. 1 scoring defense in the league.

San Francisco’s total appears low while Las Vegas’ number is a bit high. These totals would look different if this game was being played in San Francisco.

49ers vs Raiders Pick of the Day

Read more on this 49ers vs Raiders bet below.

49ers vs Raiders Prediction

49ers 33, Raiders 17

This 49ers vs Raiders matchup has blowout written all over it. Amid San Francisco’s eight-game winning streak, they have won all of those games by at least six points with six double-digit point blowouts mixed in.

The 49ers dominate inferior teams like the Raiders. 4-2 in their past six games, the Raiders have shown some fight.

But they have lost two of their past three to the Steelers and Rams while getting lucky with an improbable win over the Patriots. They should be 0-3 in their past three, in theory.

What is notable is that in those two losses, the NFL’s 12th-best scoring offense was held to fewer than 16 points in both of them. If the Rams and Steelers’ defenses can hold Derek Carr‘s offense in check, it could spell doom for that side of the ball against the 49ers’ defense, which is the stingiest in the NFL.

49ers vs Raiders Bet Tips

Here are a few 49ers vs Raiders betting trends to consider before making your bets:

  • The 49ers have covered the spread in seven of their past eight games, including six straight.
  • The Over is 4-1 in the past five games the Raiders have played facing teams with a winning record.
  • The Raiders have covered the spread in four of their past six games. In the four games the Raiders have covered, they have also cashed NFL moneyline bets.
  • The Raiders are 5-0 ATS when facing teams with a winning record.

49ers vs Raiders Best Bets

49ers -6 (-110) at Caesars Sportsbook

WAGER: 1 Unit

As six-point road favorites, the 49ers should run away with this game easily. The 49ers have won and covered in each of the past three games they have played on the road, winning each of those matchups by at least eight points.

The Raiders are mismatched in all phases.

Want to bet on the 49ers? Check out the best U.S. sportsbooks!

Over 44.5 Points (-110) at Caesars Sportsbook

WAGER: 1 Unit

The Over is 4-1 in the past five games San Francisco has played against teams with a winning record. Look for this trend to be maintained in Week 17.

The Over has also cashed in three of the past four games the 49ers have played overall.

The 49ers’ offense has been on fire with no signs of slowing down. The Raiders have struggled defensively all season long.

You do the math.

Since the 49ers have scored at least 31 points in five of eight, the Raiders will not have to do much on their end for this Over to cash.

Want to bet on the Raiders? Check out the best NV sportsbooks!

49ers vs Raiders Props

Check out the best 49ers vs Raiders player prop bets this week with our props comparison tool. Click on “Show More Games" below to find the San Francisco vs Las Vegas game and see all of its prop bets.


Anthony Cervino

Anthony Cervino is an NFL Writer and Betting Analyst for The Game Day. He is also a lifelong NFL savant and self-proclaimed league historian. In the industry, Anthony has excelled in both the fantasy football and sports betting space with fantasy his proverbial bread and butter. Anthony has made appearances on SiriusXM, amongst other publications. He is also the co-creator of the FF Faceoff (Faceoff Sports Network) and the FF Faceoff Mental Health Podathon partnered with the Hayden Hurst Foundation. Industry Clout: 15th most accurate ranker in the FantasyPros ECR for both draft and in-season accuracy (2019) | 8th most accurate ranker in the FantasyPros ECR for sleepers (2020) | 13th most accurate ranker in the FantasyPros ECR for in-season accuracy, including 2nd at quarterback and 3rd at tight end (2021).

Related articles

Create Betslip